What is Safyral: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Safyral overview

BRAND NAMES:

  • Rajani, Beyaz, Safyral, Tydemy, Beyaz, Rajani, Safyral, Tydemy

Generic Names:

  • Drospiren-Eth Estrad-Levomefol

Uses:

  • Prevents pregnancy. Also treats premenstrual dysphoric disorder (PMDD) and acne. This medicine contains a folic acid supplement., Used as a dietary supplement for depression and schizophrenia. This is a medical food.

Therapeutic Classes:

  • Contraceptive Combination, Nutriceutical, Nutritive Agent

Forms:

  • Tablet, Tablet, Tablet

How it’s taken:

  • By mouth, By mouth

What is Safyral used for?

What form(s) does Safyral come in

  • Tablet

  • Tablet

  • Tablet

What are common Safyral doses?

  • Disp Pack 28 Tablets

Common Safyral prescriptions

  • Safyral
    1 package (28 tablets), 3-0.03-0.451mg disp pack

How to take Safyral

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • If you vomit or have diarrhea within 3 to 4 hours of taking this medicine, treat this as a missed dose and follow the patient instructions or call your doctor.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Take your pills at the same time every day in the order they appear in the container. Birth control pills work best when there is no more than 24 hours between doses.

  • Use a second form of birth control for the first 7 days of your first cycle of pills. Your body will need at least 7 days to adjust to the new medicine before a pregnancy will be prevented.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • You could have light bleeding or spotting if you do not take your pills on a regular schedule.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • Missed dose: This medicine has specific patient instructions on what to do if you miss a dose. Read and follow these instructions carefully and call your doctor if you have any questions.Use a second form of birth control for the next 7 days after you miss a dose.If you miss a pill or change your schedule, you may not have a period that month. Tell your doctor if you miss your period 2 months in a row, because you may be pregnant.You could have light bleeding or spotting if you do not take your pills on a regular schedule.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Use a second form of birth control for the first 7 days of your first cycle of pills. Your body will need at least 7 days to adjust to the new medicine before a pregnancy will be prevented.

  • Missed dose: This medicine has specific patient instructions on what to do if you miss a dose. Read and follow these instructions carefully and call your doctor if you have any questions.Use a second form of birth control for the next 7 days after you miss a dose.If you miss a pill or change your schedule, you may not have a period that month. Tell your doctor if you miss your period 2 months in a row, because you may be pregnant.You could have light bleeding or spotting if you do not take your pills on a regular schedule.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your pills at the same time every day in the order they appear in the container. Birth control pills work best when there is no more than 24 hours between doses.

  • You could have light bleeding or spotting if you do not take your pills on a regular schedule.

  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

  • If you vomit or have diarrhea within 3 to 4 hours of taking this medicine, treat this as a missed dose and follow the patient instructions or call your doctor.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

What to do if you miss a dose of Safyral

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Safyral contraindications

  • Do not use this medicine if you have had an allergic reaction to L-methylfolate.

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to drospirenone, ethinyl estradiol, or levomefolate, or if you are pregnant. Do not use this medicine if you have certain heart problems, adrenal gland problems, kidney disease, liver disease, migraines, unusual vaginal bleeding that has not been checked by a doctor, or kidney, eye, nerve, or blood vessel damage caused by diabetes. Do not use this medicine if you have a history of breast cancer, blood clots, heart attack, or stroke.

Safyral warnings

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have anemia, vitamin B12 deficiency, or a history of bipolar disorder.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Tell your doctor if you are breastfeeding, or if you had a baby within the last 4 weeks. Tell your doctor if you have hereditary angioedema, diabetes, high blood pressure, high cholesterol, or a history of depression or chloasma gravidarum. Tell your doctor if you had liver problems caused by pregnancy or birth control pills. Tell your doctor if you smoke or if you are having a surgery that requires inactivity for a long time.

  • It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases. Talk to your doctor if you have concerns about this.

  • This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds.

  • This medicine may cause the following problems: Increased risk of heart attack, stroke, or blood clotsPossible increased risk of breast or cervical cancerLiver problemsHigh blood pressureGallbladder diseaseHigh cholesterol in the blood

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Safyral interactions

  • Do not use this medicine together with medicine to treat hepatitis C virus infection, including ombitasvir/paritaprevir/ritonavir, with or without dasabuvir.

  • Some foods and medicines can affect how this medicine works. Tell your doctor if you are using any of the following: Acetaminophen, ascorbic acid (vitamin C), atorvastatin, bosentan, cholestyramine, heparin, methotrexate, omeprazole, St John's wort, sulfasalazine, theophylline, tizanidineDiuretic (water pill)Folate or potassium supplementsMedicine to lower blood pressure (including diltiazem, verapamil)Medicine to treat HIV/AIDSMedicine to treat infection (clarithromycin, erythromycin, fluconazole, griseofulvin, itraconazole, ketoconazole, pyrimethamine, rifampicin, voriconazole)Medicine to treat seizures (including carbamazepine, felbamate, lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone, topiramate, valproic acid)NSAID pain or arthritis medicine (including aspirin, diclofenac, ibuprofen, naproxen)Thyroid medicine replacement

  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

  • This medicine will not protect you from HIV/AIDS or other sexually transmitted diseases. Talk to your doctor if you have concerns about this.

  • Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine before you have surgery or if you need to stay in bed for a long time. This medicine may affect the results of certain medical tests.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Make sure your doctor knows if you also use aminopterin, capecitabine (Xeloda®), fluoxetine (Prozac®), isotretinoin (Accutane®), metformin (Glucophage®), methotrexate (Trexall®), methylprednisolone (Medrol®), pentamidine (Nebupent®), pyrimethamine (Daraprim®), triamterene (Dyrenium®), trimethoprim (Bactrim®, Septra®), medicine to treat seizures (such as carbamazepine, lamotrigine, phenobarbital, phenytoin, primidone, valproic acid, Depakene®, Dilantin®, Tegretol®), an NSAID pain or arthritis medicine (such as aspirin, diclofenac, ibuprofen, indomethacin, naproxen, sulindac, Advil®, Aleve®, Celebrex®, Voltaren®), a blood thinner (such as warfarin, Coumadin®, Jantoven®), or birth control pills.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Safyral side effects

Serious Side Effects

  • Heavy vaginal bleeding, irregular or missed menstrual period

  • Vision blurring or loss

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Breast lumps, pain, tenderness, swelling, or discharge

  • Confusion, weakness, uneven heartbeat, numbness in your hands, feet, or lips

  • Chest pain or tightness, trouble breathing, coughing up blood

  • Sudden and severe stomach pain, nausea, vomiting, lightheadedness

  • Dark urine or pale stools, loss of appetite, yellow skin or eyes

  • Numbness or weakness on one side of your body, sudden or severe headache, problems with vision, speech, or walking

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Vaginal spotting or light bleeding, itching, or discharge

  • Depression or mood changes

  • Vaginal spotting or light bleeding, itching, or discharge

  • Mild headache or stomach upset

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