Safyral Coupons & Prices

Safyral is a brand-name prescription medication used to prevent ovulation and pregnancy. The generic version of Safyral is Tydemy. The average cash price of Safyral is approximately $267.56. Pay $61.24 for Safyral when you use a SingleCare savings option like a drug coupon. Present your Safyral coupon to the pharmacist at your local pharmacy including CVS Pharmacy, Walmart Pharmacy, Kroger, or Walgreens so you can get your Safyral prescription for a discounted price.

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1 disp pack1 package (28 tablets), 3-0.02-0.451mgEdit

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Safyral coupon at CVS Pharmacy
$64.24
$ 61.24
$3 off with signupwith signup

Show this free card to your pharmacist.

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Safyral coupon at Walgreens Pharmacy
$104.07
$ 101.07
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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and it's free to join

Safyral coupon at Publix Pharmacy
$105.70
$ 102.70
$3 off with signupwith signup
Safyral coupon at Kroger Pharmacy
$119.98
$ 116.98
$3 off with signupwith signup
Safyral coupon at Harris Teeter Pharmacy
$119.98
$ 116.98
$3 off with signupwith signup
Safyral coupon at Food Lion Pharmacy
$ 118.93
$ 122.06
$155.90
$ 152.90
$3 off with signupwith signup
$155.90
$ 152.90
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/20/2025

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About Safyral

Safyral is a brand-name prescription medication used to prevent ovulation and pregnancy. The generic version of Safyral is Tydemy. The average cash price of Safyral is approximately $267.56. Pay $61.24 for Safyral when you use a SingleCare savings option like a drug coupon. Present your Safyral coupon to the pharmacist at your local pharmacy including CVS Pharmacy, Walmart Pharmacy, Kroger, or Walgreens so you can get your Safyral prescription for a discounted price.

Safyral Price History & Information

Price History for Safyral (Brand) & Drospiren-Eth Estrad-Levomefol (Generic)

1 count, disp pack, 1 package (28 tablets), 3-0.02-0.451mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Safyral (Brand) & Drospiren-Eth Estrad-Levomefol (Generic)

1 count, disp pack, 1 package (28 tablets), 3-0.02-0.451mg
PharmacyDrospiren-Eth Estrad-Levomefol Retail PriceDrospiren-Eth Estrad-Levomefol SingleCare Price
Walmart$147.28$147.28
Walgreens$130.20$77.00

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Safyral

Safyral is a brand-name prescription medication used to prevent ovulation and pregnancy. The generic version of Safyral is Tydemy. The average cash price of Safyral is approximately $267.56. Pay $61.24 for Safyral when you use a SingleCare savings option like a drug coupon. Present your Safyral coupon to the pharmacist at your local pharmacy including CVS Pharmacy, Walmart Pharmacy, Kroger, or Walgreens so you can get your Safyral prescription for a discounted price.

Safyral FAQs

How much does Safyral cost without insurance?

The average cash price of Safyral, without insurance, is about $267.56 at most local pharmacies. You can fill your Safyral prescription for $61.24 per 1, 1 package (28 tablets), 3-0.02-0.451mg disp pack when you use a SingleCare savings card. You can use your coupon at popular drugstores such as CVS Pharmacy, Target, Fry's, Harris Teeter, and Walgreens.

How much does Safyral cost with insurance?

With insurance, the average copay for Safyral will vary based on the type of plan you have and the number of benefits your plan carries. You should contact your insurance provider directly to figure out your cost. You can also save on Safyral by using SingleCare's Safyral discount card. This card reduces your Safyral cost to $61.24 for 1, 1 package (28 tablets), 3-0.02-0.451mg disp pack at local pharmacies near you.

Does Medicare cover Safyral and how much does it cost?

Medicare does not typically cover Safyral, but you can use our discount card to save on this expensive prescription drug. With a SingleCare Safyral coupon, you could lower your out-of-pocket cost for your Safyral prescription or refill to $61.24.

Is there a generic of Safyral?

Safyral is a brand-name prescription medication manufactured by Bayer HealthCare Pharmaceuticals. Tydemy is the generic version of Safyral.

What is Safyral?

Safyral is a brand-name prescription medication that is FDA-approved. It is an oral contraceptive. Safyral combines two types of female hormones, estrogen, and progestin. This medication also has levomefolate, a B vitamin. Safyral is used to prevent ovulation and pregnancy. It is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD), acne, and to increase folate levels in women who want to start using birth control pills. In order to reduce nausea after taking Safyral,you should use Safyral with food. Safyral is only available with a doctor's prescription and therefore, should only be used as prescribed. Safyral should be taken at the same time every day.

You should consult with your doctor about the U.S.e of this medication with children as special care may be needed. If you have any underlying medical conditions such as vaginal bleeding, adrenal gland disease, blood clots, depression, diabetes, high blood pressure, high cholesterol, liver, or kidney disease, you should discuss the risks and benefits of using Safyral for treatment before starting use.

Drug interactions are likely to occur when using anastrozole, bosentan, exemestane, letrozole, metyrapone, testolactone. You should stop using these medications while on treatment using Safyral. You should also discuss your use of tobacco and alcohol, as smoking may increase the risk of blood clots and stroke while using Safyral. Safyral should be stored in a closed container at room temperature away from heat, moisture, and direct sunlight.

What are the side effects of Safyral?

Some of the most common side effects associated with Safyral include acne, brown spots on the face, changes in sex drive and sexual performance, depression, weight gain, stomach cramps, and bloating. If you experience allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, seek emergency help right away.

These are not all of the side effects that can occur while taking Safyral, consult your doctor for medical advice on how you can manage any side effects that you may experience.

Where are Safyral coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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