Safyral is a brand-name prescription medication used to prevent ovulation and pregnancy. The generic version of Safyral is Tydemy. The average cash price of Safyral is approximately $267.56. Pay $60.65 for Safyral when you use a SingleCare savings option like a drug coupon. Present your Safyral coupon to the pharmacist at your local pharmacy including CVS Pharmacy, Walmart Pharmacy, Kroger, or Walgreens so you can get your Safyral prescription for a discounted price.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 05/06/2026
Safyral is a brand-name prescription medication used to prevent ovulation and pregnancy. The generic version of Safyral is Tydemy. The average cash price of Safyral is approximately $267.56. Pay $60.65 for Safyral when you use a SingleCare savings option like a drug coupon. Present your Safyral coupon to the pharmacist at your local pharmacy including CVS Pharmacy, Walmart Pharmacy, Kroger, or Walgreens so you can get your Safyral prescription for a discounted price.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Drospiren-Eth Estrad-Levomefol Retail Price | Drospiren-Eth Estrad-Levomefol SingleCare Price |
|---|---|---|
| Walmart | $89.60 | $89.60 |
| Walgreens | - | - |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Safyral is a brand-name prescription medication used to prevent ovulation and pregnancy. The generic version of Safyral is Tydemy. The average cash price of Safyral is approximately $267.56. Pay $60.65 for Safyral when you use a SingleCare savings option like a drug coupon. Present your Safyral coupon to the pharmacist at your local pharmacy including CVS Pharmacy, Walmart Pharmacy, Kroger, or Walgreens so you can get your Safyral prescription for a discounted price.
The average cash price of Safyral, without insurance, is about $267.56 at most local pharmacies. You can fill your Safyral prescription for $60.65 per 1, 1 package (28 tablets), 3-0.02-0.451mg disp pack when you use a SingleCare savings card. You can use your coupon at popular drugstores such as CVS Pharmacy, Target, Fry's, Harris Teeter, and Walgreens.
With insurance, the average copay for Safyral will vary based on the type of plan you have and the number of benefits your plan carries. You should contact your insurance provider directly to figure out your cost. You can also save on Safyral by using SingleCare's Safyral discount card. This card reduces your Safyral cost to $60.65 for 1, 1 package (28 tablets), 3-0.02-0.451mg disp pack at local pharmacies near you.
Medicare does not typically cover Safyral, but you can use our discount card to save on this expensive prescription drug. With a SingleCare Safyral coupon, you could lower your out-of-pocket cost for your Safyral prescription or refill to $60.65.
Safyral is a brand-name prescription medication manufactured by Bayer HealthCare Pharmaceuticals. Tydemy is the generic version of Safyral.
Safyral is a brand-name prescription medication that is FDA-approved. It is an oral contraceptive. Safyral combines two types of female hormones, estrogen, and progestin. This medication also has levomefolate, a B vitamin. Safyral is used to prevent ovulation and pregnancy. It is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD), acne, and to increase folate levels in women who want to start using birth control pills. In order to reduce nausea after taking Safyral,you should use Safyral with food. Safyral is only available with a doctor's prescription and therefore, should only be used as prescribed. Safyral should be taken at the same time every day.
You should consult with your doctor about the U.S.e of this medication with children as special care may be needed. If you have any underlying medical conditions such as vaginal bleeding, adrenal gland disease, blood clots, depression, diabetes, high blood pressure, high cholesterol, liver, or kidney disease, you should discuss the risks and benefits of using Safyral for treatment before starting use.
Drug interactions are likely to occur when using anastrozole, bosentan, exemestane, letrozole, metyrapone, testolactone. You should stop using these medications while on treatment using Safyral. You should also discuss your use of tobacco and alcohol, as smoking may increase the risk of blood clots and stroke while using Safyral. Safyral should be stored in a closed container at room temperature away from heat, moisture, and direct sunlight.
Some of the most common side effects associated with Safyral include acne, brown spots on the face, changes in sex drive and sexual performance, depression, weight gain, stomach cramps, and bloating. If you experience allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, seek emergency help right away.
These are not all of the side effects that can occur while taking Safyral, consult your doctor for medical advice on how you can manage any side effects that you may experience.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved