What is Spiriva Respimat: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Spiriva Respimat is a brand-name prescription drug used as a maintenance treatment for asthma and chronic obstructive pulmonary disease (COPD), a lung disease that includes emphysema and chronic bronchitis. Its active ingredient is tiotropium. Spiriva works by relaxing the muscles in the airways to improve breathing and reduce the incidence of attacks and exacerbations. The once-a-day dose is taken with a spray inhaler.

Spiriva Respimat overview

BRAND NAMES:

  • Spiriva Respimat, Spiriva Handihaler

Generic Names:

  • Tiotropium bromide

Uses:

  • Treats asthma and chronic obstructive pulmonary disease (COPD)

Therapeutic Classes:

  • Bronchodilator, anticholinergic

Forms:

  • Spray inhaler

How it’s taken:

  • Inhalation

What is Spiriva Respimat used for?

Spiriva Repimat is a spray inhaler used for the maintenance of asthma and chronic obstructive pulmonary disease (COPD), a lung disease that includes emphysema and chronic bronchitis.

What form(s) does Spiriva Respimat come in

  • Inhaler 

    • 1.25 mcg/actuation

    • 2.5 mcg/actuation

What are common Spiriva Respimat doses?

  • For the maintenance treatment of asthma: Two inhalations of Spiriva Respimat 1.25 mcg/actuation once daily for a total daily dose of 2.5 mcg

  • For the maintenance treatment of COPD: Two inhalations of Spiriva Respimat 2.5 mcg/actuation once daily for a total daily dose of 5 mcg

Common Spiriva Respimat prescriptions

  • Spiriva Respimat
    4gm of 1.25mcg/act (60 inhalations) inhaler

  • Spiriva Respimat
    4gm of 2.5mcg/act inhaler

  • Spiriva Respimat
    4gm of 2.5mcg/act (10 inhalations) inhaler

  • Spiriva Respimat
    4gm of 2.5mcg/act (28 inhalations) inhaler

  • Spiriva Respimat
    4gm of 2.5mcg/act (60 inhalations) inhaler

How to take Spiriva Respimat

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Check the medication to make sure you have the right dose. 

    • Asthma patients will use the inhaler with the blue cap (1.25 mcg/actuation). 

    • COPD patients will use the inhaler with the green cap (2.5 mcg/actuation).

  • Read and follow the Instructions for Use that come with the inhaler.

  • Take the dose at the same time each day.

  • Children using Spiriva Respimat should be helped by an adult.

  • The cartridge containing the medicine must first be inserted into the inhaler.

    • Keep the cap closed on the inhaler.

    • Press the safety catch and pull off the clear cartridge from the inhaler.

    • Write the discard by date (three months after the cartridge is inserted).

    • Insert the narrow end of the cartridge into the inhaler.

    • With the inhaler on a firm surface, press down on the top until it clicks. The cartridge is now in place.

    • Put the clear base back on the inhaler. Turn it in the direction of the arrows until it clicks.

  • Prime the inhaler after the cartridge has first been inserted.

    • Follow the instructions in the Instructions for Use.

    • If the inhaler isn’t used for 21 days or more, prime the inhaler again before use.

  • Watch the dose indicator.

    • The dose indicator shows the number of puffs in the inhaler. Two puffs equal one dose.

    • When the dose indicator is in the red zone, refill your prescription.

    • When the dose indicator is at zero, the inhaler will stop working.

  • Take a dose.

    • To take a dose, turn the clear base in the direction of the arrows until it clicks. One puff is now ready to take.

    • Open the cap.

    • Fully breathe out slowly.

    • Completely close your lips around the mouthpiece, but don’t cover the air vents.

    • Start breathing in slowly and deeply. While doing so, press the dose release button and keep inhaling.

    • Hold your breath for 10 seconds.

    • Turn the cartridge again in the direction of the arrows until it clicks. The second puff is now ready.

    • Take the second puff as you did the first.

    • Close the cap.

  • Clean the mouthpiece at least once weekly with a damp cloth or tissue.

  • Store Spiriva Respimat at room temperature. Do not freeze the cartridge or inhaler.

  • Throw away the inhaler three months after its first use.

What to do if you miss a dose of Spiriva Respimat

  • A missed dose can be taken when remembered, but the next dose can’t be taken until 24 hours later. Ask the prescriber for advice on taking a missed dose.

  • Do not take two doses to make up for a missed dose.

Spiriva Respimat contraindications

  • This medicine is not right for everyone. 

  • Do not use it if you have had an allergic reaction to tiotropium or ipratropium.

Spiriva Respimat warnings

  • The prescribing healthcare provider will need to check the effectiveness of Spiriva treatment at regular visits. Keep all appointments.

  • Tell any doctor or other healthcare provider who treats you that you are using Spiriva and other inhaled medicines. 

  • Before starting Spiriva Respimat, tell the prescriber if you are pregnant, breastfeeding, or have:

    • Kidney problems

    • Glaucoma

    • Enlarged prostate

    • Trouble urinating

    • Urinary blockage

  • Spiriva Respimat can cause serious problems, including:

    • Asthma-like attacks (bronchospasm) that can be life-threatening

    • Worsening of narrow-angle glaucoma

    • Worsening of urinary retention

  • Do not get Spiriva Respimat in the eyes. Call a doctor if this happens.

  • Spiriva Respimat can cause dizziness or blurred vision. Be cautious when driving or engaging in any other potentially hazardous activity that requires attention and alertness.

Spiriva Respimat interactions

  • Spiriva Respimat has only a limited number of drug interactions.

  • Even so, make sure to tell the prescriber about all the drugs and supplements you use before starting Spiriva, particularly medications called anticholinergics. A complete list of anticholinergic drugs can be found here.

  • Since many bronchodilators are anticholinergic drugs, make sure the prescriber knows about all the drugs you’re taking to treat asthma or COPD.

Spiriva Respimat side effects

Serious side effects

Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:

  • Eye pain or redness, pressure over the eye, extreme headache, blurred vision, extreme sensitivity to light

  • Sudden worsening of breathing

  • Trouble passing urine, infrequent urination, painful urination

  • Allergic reaction: hives, itching, rash, swelling in your face, lips, or tongue, trouble swallowing, trouble breathing

Less serious side effects

  • Sore throat

  • Dry mouth

  • Sinus infection

  • Cough