What is Sprix? Uses, warnings & side effects

Updated May 14, 2025  •  Published Jun 17, 2021

Sprix overview

BRAND NAMES:

  • Sprix

Generic Names:

  • Ketorolac Tromethamine

Uses:

  • Treats moderate to severe pain. This medicine is an NSAID.

Therapeutic Classes:

  • Analgesic

Forms:

  • Spray

How it’s taken:

  • Into the nose

What is Sprix used for?

Sprix is a short-term nasal spray. It works by minimizing the amount of substance in the body that causes inflammation, fever, and pain. Sprix should only be used for a period of 5 days or less.

What form(s) does Sprix come in?

  • Spray

What are common Sprix dosages?

  • Spray Btl 1 Solution

Sprix images - What does Sprix look like?

  • Sprix
    1 solution spray btl

How to take Sprix

  • Your doctor will tell you how much medicine to use. Do not use more than directed. Use each bottle for one day only.

  • Nasal routeThis medicine is for use only in the nose. Do not get any of it in your eyes or on your skin. If it does get on these areas, rinse it off right away. Do not breathe in this medicine while spraying.

  • The first time you use each bottle, you will need to prime the pump. To do this, pump the bottle 5 times until some of the medicine sprays out. The bottle is now ready to use.

  • Nasal routeAfter using the nasal spray, wipe the tip of the bottle with a clean tissue and put the cap back on.

  • Nasal routeBefore using the medicine, gently blow your nose to clear the nostrils.

  • This medicine is not for long-term use. Do not use it for more than 5 days in a row.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Drink extra fluids so you will urinate more often and help prevent kidney problems.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Keep the unopened bottle in the refrigerator. Once opened, store the bottle at room temperature, away from heat and direct sunlight. Throw away any unused medicine 24 hours after you opened the bottle and used your first dose. Do this even if some medicine remains in the bottle.

What to do if you miss a dose of Sprix

Sprix contraindications - Who shouldn't take Sprix?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to ketorolac, ethylenediamine tetraacetic acid (EDTA), aspirin, or other similar medicines.

Sprix warnings

  • Red or black stools, severe stomach pain, vomiting blood or material that looks like coffee grounds

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • This medicine may cause the following problems: Higher risk of blood clots, heart failure, heart attack, or strokeBleeding in your stomach or intestinesLiver problemsHigh blood pressureKidney problems and high potassium levelsSerious skin reactions

  • Tell your doctor if you have kidney disease, liver disease, asthma, anemia, blood clotting problems, heart failure, high blood pressure, heart or blood vessel problems, a recent heart attack, or a history of stomach ulcers or bleeding problems. Tell your doctor if you drink alcohol.

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy, unless your doctor tells you to.

Sprix interactions & what to avoid when taking Sprix

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not use this medicine together with pentoxifylline or probenecid.

  • Do not use any other forms of ketorolac (such as injection or tablets) or other NSAIDs, unless your doctor says it is okay. Some other NSAIDs include aspirin, diclofenac, diflunisal, ibuprofen, naproxen, or salsalate.

  • Some foods and medicines can affect how ketorolac works. Tell your doctor if you are using any of the following: Alprazolam, carbamazepine, digoxin, fluoxetine, lithium, methotrexate, pemetrexed, phenytoin, thiothixeneBlood pressure medicineBlood thinner (including heparin, warfarin)Diuretic (water pill)Medicine to treat depressionSteroid medicine

Sprix side effects - How does Sprix make you feel?

Serious Side Effects

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, yellow skin or eyes

  • Red or black stools, severe stomach pain, vomiting blood or material that looks like coffee grounds

  • Blistering, peeling, or red skin rash

  • Change in how much or how often you urinate

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Numbness or weakness in your arm or leg, or on one side of your body, pain in your lower leg, sudden or severe headache, or problems with vision, speech, or walking

  • Chest pain that may spread to your arms, jaw, back, or neck, trouble breathing, unusual sweating, fainting

  • Rapid weight gain, swelling in your hands, ankles, or feet

Less Serious Side Effects

  • Nasal discomfort or irritation

  • Constipation, diarrhea, heartburn, stomach pain, or upset stomach

  • Dizziness

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