Diphenhydramine is a first-generation antihistamine that is used for allergies, cold symptoms, and sleep. It is available over the counter. The average cost of Diphenhydramine without insurance is $13.44 per 30, 25mg tablets. If you have a healthcare provider write a prescription, you can use a Diphenhydramine coupon from SingleCare to pay as little as $9.16 for 30, 25mg tablets.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 07/19/2026
Diphenhydramine is a first-generation antihistamine that is used for allergies, cold symptoms, and sleep. It is available over the counter. The average cost of Diphenhydramine without insurance is $13.44 per 30, 25mg tablets. If you have a healthcare provider write a prescription, you can use a Diphenhydramine coupon from SingleCare to pay as little as $9.16 for 30, 25mg tablets.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Diphenhydramine Hcl Retail Price | Diphenhydramine Hcl SingleCare Price |
|---|---|---|
| Walmart | $6.00 | $6.00 |
| Walgreens | - | - |
| Kroger Pharmacy | $52.67 | $52.67 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Diphenhydramine is a first-generation antihistamine that is used for allergies, cold symptoms, and sleep. It is available over the counter. The average cost of Diphenhydramine without insurance is $13.44 per 30, 25mg tablets. If you have a healthcare provider write a prescription, you can use a Diphenhydramine coupon from SingleCare to pay as little as $9.16 for 30, 25mg tablets.
The generic of Diphenhydramine costs $9.16 for 30, 25mg tablets with a free Diphenhydramine coupon from SingleCare. But, you could pay even less depending on your Rx information. Use the dropdown menu above to enter your prescription details (i.e., brand/generic, quantity, form, dosage) to find the most accurate price of Diphenhydramine with SingleCare at your local pharmacies.
Those without insurance coverage can expect to purchase Diphenhydramine at an average retail price of $13.44 per 30, 25mg tablets. With a SingleCare Diphenhydramine coupon without insurance, generic Diphenhydramine could be purchased as a prescription for as little as $9.16 for 30, 25mg tablets at participating local pharmacies.
Insurance plans do not always cover Diphenhydramine because it can be purchased over the counter. Whether or not a plan covers Diphenhydramine depends on its formulary and deductible. If covered, the out-of-pocket cost may vary by plan details. Using a SingleCare Diphenhydramine coupon may cost less than using insurance. Ask your insurance plan or pharmacy for a price comparison.
The cost of Diphenhydramine with Medicare depends on a person’s plan, deductible, and coverage stage. A free SingleCare coupon for Diphenhydramine can be used instead of Medicare when it doesn’t cover Diphenhydramine or if the copay with it is higher than SingleCare’s Diphenhydramine price.
Medicaid may cover Diphenhydramine, but coverage varies by state. When Diphenhydramine is not covered, a SingleCare Diphenhydramine coupon can be used instead of Medicaid at a participating pharmacy. The lowest SingleCare price for generic Diphenhydramine is $9.16 for 30, 25mg tablets.
Benadryl is the brand-name version of Diphenhydramine.
If Diphenhydramine is still too expensive, use a free SingleCare savings card to pay as little as $9.16 for 30, 25mg tablets of generic Diphenhydramine. Signing up for SingleCare’s loyalty program can help you save even more each month.
There are other potential ways to save on Diphenhydramine, such as:
Asking your healthcare provider for free samples, although this is not a long-term solution to reduce savings
Shopping around to see the cost of Diphenhydramine at different pharmacies
Applying for Medicare Extra Help if eligible
Using a flexible spending account (FSA) or health savings account (HSA) if available
Switching to an alternative medication
There are alternatives to Diphenhydramine that may be cheaper, depending on the store or pharmacy. Some alternative antihistamines include Claritin (loratadine), Zyrtec (cetirizine), and Xyzal (levocetirizine). Check with your healthcare provider or pharmacist to find out which option is best for you. If an alternative to Diphenhydramine is needed as a sleep aid, Unisom (doxylamine) and melatonin can be considered.
SingleCare coupons are accepted at most major pharmacies and grocers, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Text, email, print, or save your free Diphenhydramine coupon to your digital wallet and show a pharmacist at the counter.
Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved