Diphenhydramine Coupons & Prices

M-Dryl

Diphenhydramine is a first-generation antihistamine that is used for allergies, cold symptoms, and sleep. It is available over the counter. The average cost of Diphenhydramine without insurance is $13.44 per 30, 25mg tablets. If you have a healthcare provider write a prescription, you can use a Diphenhydramine coupon from SingleCare to pay as little as $9.16 for 30, 25mg tablets.

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Diphenhydramine coupon at Food Lion Pharmacy
$ 9.16

Show this free card to your pharmacist.

This coupon is not insurance.
Diphenhydramine coupon at Kroger Pharmacy
$12.94
$ 9.94
$3 off with signupwith signup
Diphenhydramine coupon at Harris Teeter Pharmacy
$12.94
$ 9.94
$3 off with signupwith signup
Diphenhydramine coupon at Costco Pharmacy
$ 11.16
Diphenhydramine coupon at Publix Pharmacy
$15.21
$ 12.21
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 07/19/2026

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About Diphenhydramine

Diphenhydramine is a first-generation antihistamine that is used for allergies, cold symptoms, and sleep. It is available over the counter. The average cost of Diphenhydramine without insurance is $13.44 per 30, 25mg tablets. If you have a healthcare provider write a prescription, you can use a Diphenhydramine coupon from SingleCare to pay as little as $9.16 for 30, 25mg tablets.

Diphenhydramine Price History & Information

Price History for Diphenhydramine Hcl

30 count, Tablet, 25mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Diphenhydramine Hcl

30 count, Tablet, 25mg
PharmacyDiphenhydramine Hcl Retail PriceDiphenhydramine Hcl SingleCare Price
Walmart$6.00$6.00
Walgreens--
Kroger Pharmacy$52.67$52.67

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Diphenhydramine

Diphenhydramine is a first-generation antihistamine that is used for allergies, cold symptoms, and sleep. It is available over the counter. The average cost of Diphenhydramine without insurance is $13.44 per 30, 25mg tablets. If you have a healthcare provider write a prescription, you can use a Diphenhydramine coupon from SingleCare to pay as little as $9.16 for 30, 25mg tablets.

Diphenhydramine FAQs

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

How much is Diphenhydramine with SingleCare?

The generic of Diphenhydramine costs $9.16 for 30, 25mg tablets with a free Diphenhydramine coupon from SingleCare. But, you could pay even less depending on your Rx information. Use the dropdown menu above to enter your prescription details (i.e., brand/generic, quantity, form, dosage) to find the most accurate price of Diphenhydramine with SingleCare at your local pharmacies.

How much does Diphenhydramine cost without insurance?

Those without insurance coverage can expect to purchase Diphenhydramine at an average retail price of $13.44 per 30, 25mg tablets. With a SingleCare Diphenhydramine coupon without insurance, generic Diphenhydramine could be purchased as a prescription for as little as $9.16 for 30, 25mg tablets at participating local pharmacies.

How much does Diphenhydramine cost with insurance?

Insurance plans do not always cover Diphenhydramine because it can be purchased over the counter. Whether or not a plan covers Diphenhydramine depends on its formulary and deductible. If covered, the out-of-pocket cost may vary by plan details. Using a SingleCare Diphenhydramine coupon may cost less than using insurance. Ask your insurance plan or pharmacy for a price comparison. 

Does Medicare cover Diphenhydramine?

The cost of Diphenhydramine with Medicare depends on a person’s plan, deductible, and coverage stage. A free SingleCare coupon for Diphenhydramine can be used instead of Medicare when it doesn’t cover Diphenhydramine or if the copay with it is higher than SingleCare’s Diphenhydramine price.

Does Medicaid cover Diphenhydramine?

Medicaid may cover Diphenhydramine, but coverage varies by state. When Diphenhydramine is not covered, a SingleCare Diphenhydramine coupon can be used instead of Medicaid at a participating pharmacy. The lowest SingleCare price for generic Diphenhydramine is $9.16 for 30, 25mg tablets.

What is the brand name for Diphenhydramine?

Benadryl is the brand-name version of Diphenhydramine.

Ways to save on Diphenhydramine

If Diphenhydramine is still too expensive, use a free SingleCare savings card to pay as little as $9.16 for 30, 25mg tablets of generic Diphenhydramine. Signing up for SingleCare’s loyalty program can help you save even more each month.

There are other potential ways to save on Diphenhydramine, such as:

  • Asking your healthcare provider for free samples, although this is not a long-term solution to reduce savings

  • Shopping around to see the cost of Diphenhydramine at different pharmacies

  • Applying for Medicare Extra Help if eligible

  • Using a flexible spending account (FSA) or health savings account (HSA) if available

  • Switching to an alternative medication

Is there a cheaper alternative to Diphenhydramine?

There are alternatives to Diphenhydramine that may be cheaper, depending on the store or pharmacy. Some alternative antihistamines include Claritin (loratadine), Zyrtec (cetirizine), and Xyzal (levocetirizine). Check with your healthcare provider or pharmacist to find out which option is best for you. If an alternative to Diphenhydramine is needed as a sleep aid, Unisom (doxylamine) and melatonin can be considered.

How to use SingleCare for Diphenhydramine

SingleCare coupons are accepted at most major pharmacies and grocers, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. Text, email, print, or save your free Diphenhydramine coupon to your digital wallet and show a pharmacist at the counter.

Medically reviewed by Josephine BawabPharm.D.
Licensed Pharmacist

Josephine Bawab, Pharm.D., graduated from Virginia Commonwealth University School of Pharmacy. She began working in community pharmacy in 2012 and has worked for multiple chain pharmacies since then. She is passionate about helping patients and precepting students. She currently works and resides in Virginia, where she is just a few minutes away from the beach.

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Where are Diphenhydramine coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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