Synarel is a brand-name prescription nasal spray that treats early (precocious) puberty in boys and girls and endometriosis in women. Both are conditions caused by male hormones (testosterone) or female hormones (estrogen). Synarel works by shutting down the production of male hormones by the testes and female hormones by the ovaries. The Synarel cost is normally $3,778.77 at full price. A SingleCare Synarel coupon reduces that price to $2,989.37.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/19/2025
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Synarel is a brand-name prescription nasal spray that treats early (precocious) puberty in boys and girls and endometriosis in women. Both are conditions caused by male hormones (testosterone) or female hormones (estrogen). Synarel works by shutting down the production of male hormones by the testes and female hormones by the ovaries. The Synarel cost is normally $3,778.77 at full price. A SingleCare Synarel coupon reduces that price to $2,989.37.
Synarel is a brand-name prescription nasal spray that treats early (precocious) puberty in boys and girls and endometriosis in women. Both are conditions caused by male hormones (testosterone) or female hormones (estrogen). Synarel works by shutting down the production of male hormones by the testes and female hormones by the ovaries. The Synarel cost is normally $3,778.77 at full price. A SingleCare Synarel coupon reduces that price to $2,989.37.
Synarel costs $3,778.77 for uninsured customers. With a SingleCare Synarel coupon, you will pay only $2,989.37 for 8, 2mg/ml solution (quantity in ml)s of Synarel.
Your copay for Synarel with insurance will vary depending on your plan. Because your cost using a SingleCare Synarel coupon may be lower than your insurance copay, ask your pharmacist to do a price comparison. For instance, you can get 8, 2mg/ml solution (quantity in ml)s for $2,989.37 at a pharmacy that accepts SingleCare coupons. Compare our lowest price to your copay before you overpay for Synarel and other prescription drugs.
Synarel is usually covered under Medicare Part D and Medicare Advantage prescription drug plans. Patients without Medicare should consider bringing a SingleCare Synarel coupon with them to any one of a number of participating pharmacies. With SingleCare, the price of Synarel would be $2,989.37.
Synarel is a brand-name prescription drug with the active ingredient, nafarelin. Generic Synarel is not available at this time.
Synarel is a brand-name prescription drug that treats precocious puberty in boys and girls and endometriosis in women.
Endometriosis is a condition where the inner lining of the uterus, the endometrium, grows on the outside of the uterus. This growth is stimulated by the female hormone estrogen.
Precocious puberty is any onset of puberty in girls 8 years or younger or boys 9 years and younger. It is caused by the release of a hormone, gonadotropin-releasing hormone, which stimulates the pituitary gland to release hormones that stimulate the ovaries to produce the female hormone estrogen and the testes to produce the male hormone testosterone.
The active ingredient in Synarel, nafarelin, attaches to the same places in the pituitary gland that gonadotropin-releasing hormone attaches to. After a few weeks, continual intake of nafarelin completely shuts down the production of the hormones produced by the pituitary gland that stimulates sex hormone production, which also shuts down. This stops the development of secondary sexual characteristics in children with precocious puberty and decreases their growth rate to normal levels. The reduction in estrogen stops the growth rate of endometrial tissues on the uterus.
Synarel is administered as a nasal spray, two sprays in each nostril in the morning, and two sprays in each nostril in the evening.
Common side effects of Synarel include, but are not limited to, nasal irritation, headache, oily skin, acne, runny nose, vaginal discharge, vaginal dryness, hot flashes, pubic hair growth, changes in breast size, increased body odor, dandruff, and muscle pain. Mental and mood changes include mood swings and depression.
Serious but rare side effects of Synarel include stroke and heart attack.Allergic reactions are rare.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved