What is Synjardy XR: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Synjardy XR overview

BRAND NAMES:

  • Synjardy, Synjardy XR

Generic Names:

  • Synjardy Xr

Uses:

  • Treats type 2 diabetes. Also used to lower risk of death in patients with type 2 diabetes and heart or blood vessel problems.

Therapeutic Classes:

  • Hypoglycemic

Forms:

  • Tablet, Long Acting Tablet

How it’s taken:

  • By mouth

What is Synjardy XR used for?

What form(s) does Synjardy XR come in

  • Tablet

  • Long Acting Tablet

What are common Synjardy XR doses?

  • Tablet 10mg/1000mg

  • Tablet 12.5mg/1000mg

  • Tablet 5mg/1000mg

  • Tablet 25mg/1000mg

Common Synjardy XR prescriptions

  • Synjardy XR
    10-1000mg er 24hr (xr) tablet extended release 24 hour

  • Synjardy XR
    12.5-1000mg er 24hr (xr) tablet extended release 24 hour

  • Synjardy XR
    25-1000mg, er 24hr (xr) tablet extended release 24 hour

  • Synjardy XR
    5-1000mg er 24hr (xr) tablet extended release 24 hour

How to take Synjardy XR

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. A part of the extended-release tablet may pass into your stool. Talk to your doctor if you see tablet pieces in your stool.

  • Oral routeIt is best to take this medicine with food or milk.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. A part of the extended-release tablet may pass into your stool. Talk to your doctor if you see tablet pieces in your stool.

  • Oral routeIt is best to take this medicine with food or milk.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

What to do if you miss a dose of Synjardy XR

Synjardy XR contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to empagliflozin or metformin.

Synjardy XR warnings

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results. You may need to stop taking this medicine at least 3 days before surgery.

  • Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.

  • This medicine may cause the following problems:Lactic acidosis (too much acid in the blood)Low blood pressureKetoacidosis (high ketones and acid in the blood)Kidney problemsLow blood sugar, when used with other diabetes medicineIncreased risk of genital yeast or urinary tract infectionsFournier's gangrene (skin or tissue damage of the area between the anus and genitals)High cholesterol level

  • Tell your doctor if have kidney disease, liver disease, heart failure, high cholesterol, adrenal or pituitary gland problems, vitamin B12 deficiency, or a history of pancreas problems or urinary tract or genital yeast infections. Tell your doctor if you are on a low-salt diet.

  • Tell your doctor if you are pregnant or breastfeeding. If you had problems ovulating or have irregular periods, this medicine may cause you to ovulate, which could lead to pregnancy if you are sexually active. Talk to your doctor about effective birth control while you are using this medicine.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Synjardy XR interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Limit the amount of alcohol you drink. Heavy alcohol use increases your risk for lactic acidosis.

  • Limit the amount of alcohol you drink.

  • Some medicines can affect how empagliflozin/metformin works. Tell your doctor about all other medicines that you are using, including the following:Acetazolamide, amiloride, cimetidine, dichlorphenamide, digoxin, dolutegravir, isoniazid, morphine, nicotinic acid, procainamide, quinidine, quinine, ranitidine, ranolazine, topiramate, triamterene, trimethoprim, vancomycin, vandetanib, zonisamideBirth control pills (including estrogen)Blood pressure medicineDiuretic (water pill)Insulin or other diabetes medicineMedicine to treat mental illnessNSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Phenothiazine medicineSteroid medicineThyroid medicine

Synjardy XR side effects

Serious Side Effects

  • Fast or troubled breathing, nausea, vomiting, stomach pain, severe weakness, tiredness

  • Change in how much or how often you urinate, bloody urine, difficult or painful urination, lower back or side pain, fever, chills

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Pain, tenderness, redness, or swelling of the area between the anus and genitals, fever, unusual tiredness or weakness

  • Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion

  • Lightheadedness, dizziness, fainting

Less Serious Side Effects

  • Redness, itching, pain, or swelling of the penis, bad-smelling discharge from the penis

  • White or yellow vaginal discharge, vaginal itching or odor

  • Stuffy or runny nose, sore throat

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