What is Trisenox: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Feb 14, 2024

Trisenox overview

BRAND NAMES:

  • Trisenox

Generic Names:

  • Trisenox

Uses:

  • Treats acute promyelocytic leukemia (APL).

Therapeutic Classes:

  • Antineoplastic Agent

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Trisenox used for?

What form(s) does Trisenox come in

  • Injectable

What are common Trisenox doses?

  • Vial 6ml of 12mg/6ml

Common Trisenox prescriptions

  • Trisenox
    6ml of 12mg/6ml vial

How to take Trisenox

  • Injection routeYour doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.

  • Injection routeYou will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.

  • Missed dose: Injection routeThis medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.

What to do if you miss a dose of Trisenox

Trisenox contraindications

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to arsenic trioxide, or if you are pregnant or breastfeeding.

Trisenox warnings

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

  • Injection routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control to keep from getting pregnant during treatment with this medicine and for 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment with this medicine and for 3 months after the last dose.

  • Do not breastfeed during treatment with this medicine and for 2 weeks after the last dose.

  • Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, vitamin B1 deficiency, poor nutrition, malabsorption, electrolyte imbalance, or a history of heart rhythm problems (including QT prolongation). Tell your doctor if you drink alcohol regularly.

  • This medicine may cause the following problems:APL differentiation syndromeHeart rhythm problemsBrain disease, including Wernicke€™s encephalopathyLiver problemsIncreased risk for other cancers

  • Talk with your doctor before using this medicine if you plan to have children. Some men who use this medicine have become infertile (unable to have children).

  • Injection routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

Trisenox interactions

  • Some medicines can affect how arsenic trioxide works. Tell your doctor if you are using any of the following: Amphotericin BDiuretic (water pill)Medicine for heart rhythm problems

  • Do not breastfeed while you are using this medicine. Tell your doctor if you have kidney disease, liver disease, heart disease, heart failure, or a history of heart rhythm problems (such as QT prolongation).

  • This medicine may cause the following problems:APL differentiation syndromeChanges in heart rhythmIncreased risk for other cancers

  • Injection routeCancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Trisenox side effects

Serious Side Effects

  • Fast, pounding, or uneven heartbeat

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Confusion, loss of consciousness, seizures, blurred vision or changes in vision, problems with memory or learning, shakiness or trembling, unsteady walk

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Chest pain

  • Fever, trouble breathing

  • Fainting, dizziness, lightheadedness

  • Rapid weight gain, swelling in your hands, ankles, or feet

Less Serious Side Effects

  • Cough

  • Redness, pain, or swelling where the needle is placed

  • Headache, trouble sleeping

  • Diarrhea

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