Tyrvaya, also known as varenicline solution, is a prescription medication for dry eye disease. It is a brand-name nasal spray not currently available in a generic form. As a highly selective cholinergic agonist, Tyrvaya works by stimulating the production of natural tears to reduce dryness and discomfort. On average, the retail price of Tyrvaya is $931.16 for 8.40, 0.03mg/act solution (quantity in ml)s. However, with a SingleCare Tyrvaya coupon, patients may be able to reduce expenses, potentially paying as low as $670.65 for 8.4, 0.03mg/act solution (quantity in ml)s at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Tyrvaya, also known as varenicline solution, is a prescription medication for dry eye disease. It is a brand-name nasal spray not currently available in a generic form. As a highly selective cholinergic agonist, Tyrvaya works by stimulating the production of natural tears to reduce dryness and discomfort. On average, the retail price of Tyrvaya is $931.16 for 8.40, 0.03mg/act solution (quantity in ml)s. However, with a SingleCare Tyrvaya coupon, patients may be able to reduce expenses, potentially paying as low as $670.65 for 8.4, 0.03mg/act solution (quantity in ml)s at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Tyrvaya Retail Price | Tyrvaya SingleCare Price |
|---|---|---|
| CVS Pharmacy | $810.01 | $720.97 |
| Walmart | $822.44 | $725.17 |
| Walgreens | $822.02 | $726.26 |
| Kroger Pharmacy | $822.53 | $675.28 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Tyrvaya, also known as varenicline solution, is a prescription medication for dry eye disease. It is a brand-name nasal spray not currently available in a generic form. As a highly selective cholinergic agonist, Tyrvaya works by stimulating the production of natural tears to reduce dryness and discomfort. On average, the retail price of Tyrvaya is $931.16 for 8.40, 0.03mg/act solution (quantity in ml)s. However, with a SingleCare Tyrvaya coupon, patients may be able to reduce expenses, potentially paying as low as $670.65 for 8.4, 0.03mg/act solution (quantity in ml)s at participating pharmacies.
Without insurance coverage, Tyrvaya can cost an average retail price of $931.16 for 8.40, 0.03mg/act solution (quantity in ml)s. Costs for cash-paying patients and those without health insurance may vary, however, depending on pharmacy location and other factors. With SingleCare's discount program, the price could be lowered to $670.65 for 8.4, 0.03mg/act solution (quantity in ml)s. Compare cash prices with discounts on the SingleCare website for maximum savings.
Tyrvaya may be covered by some health insurance plans. However, the cost with insurance depends on the specific plan and its formulary. While many commercial insurance plans may cover a portion of the cost, patients may be responsible for out-of-pocket costs, such as copays and coinsurance amounts. Consult your insurance provider or pharmacist to determine the exact cost of your monthly prescription. In some cases, the savings from SingleCare might even surpass what your insurance company offers.
Medicare plans may help cover the cost of Tyrvaya. However, medicare coverage will vary based on the plan and the prescription details. Those without Medicare can still benefit from SingleCare's discounts, often finding lower prices with SingleCare than with Medicare itself. Always compare the costs of your medicines to potentially get a discounted price, which could be as low as $670.65 for 8.4, 0.03mg/act solution (quantity in ml)s.
Currently, Tyrvaya is a brand-name drug with no generic equivalent available. It is currently manufactured by Oyster Point Pharma. The patent for Tyrvaya is expected to expire in 2035, when a generic version may be released.
Tyrvaya is a prescription nasal spray designed to treat symptoms of dry eye disease. It may be prescribed when other treatments have not provided sufficient relief. Tyrvaya works by activating certain receptors in the nervous system, which in turn stimulates natural tear production. As a result, Tyrvaya may help relieve the discomfort associated with dry eye disease, making it a potential option for many patients.
Tyrvaya comes as a nasal spray that delivers 0.03 mg of varenicline with each spray. The typical dosage is one spray in each nostril twice daily, with each dose separated by around 12 hours. The nasal spray should be primed with seven actuations before the first use and reprimed with one actuation if the nasal spray isn’t used for more than five days. Always use Tyrvaya under the guidance and expertise of a licensed healthcare provider.
Common side effects of Tyrvaya include:
Mild irritation or discomfort in the nose
Sneezing
Cough
More serious adverse effects are possible, such as severe nasal irritation or allergic reactions. Consult your doctor or healthcare provider for additional information and professional medical advice regarding potential side effects of Tyrvaya.
Both Tyrvaya and Restasis are effective medicines for treating dry eye disease. However, they work in different ways. Tyrvaya is a nasal spray that contains a cholinergic agonist called varenicline, while Restasis is a prescription eye drop that contains an immunosuppressant called cyclosporine. According to some clinical trials, Tyrvaya nasal spray may be more effective than Restasis eye drops in improving tear production for people with dry eye disease.
Yes, Tyrvaya is specifically designed to treat dry eye disease. It works by stimulating the body's natural tear production, which may help relieve the symptoms of dry eyes. Consult a healthcare provider for any questions or concerns about the use of Tyrvaya. This medication may only be prescribed after an appropriate diagnosis.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved