Premphase is a combination prescription drug used for the treatment of menopause symptoms such as hot flashes and vaginal changes. It can also be used to prevent osteoporosis (bone loss) in menopausal women. There is currently no generic version of Premphase available. The average cost of Premphase is about $301.86. Use a free SingleCare Premphase coupon at participating pharmacies such as Walgreens, Walmart or CVS to reduce your out-of-pocket cost to $229.63.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Premphase is a combination prescription drug used for the treatment of menopause symptoms such as hot flashes and vaginal changes. It can also be used to prevent osteoporosis (bone loss) in menopausal women. There is currently no generic version of Premphase available. The average cost of Premphase is about $301.86. Use a free SingleCare Premphase coupon at participating pharmacies such as Walgreens, Walmart or CVS to reduce your out-of-pocket cost to $229.63.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Premphase is a combination prescription drug used for the treatment of menopause symptoms such as hot flashes and vaginal changes. It can also be used to prevent osteoporosis (bone loss) in menopausal women. There is currently no generic version of Premphase available. The average cost of Premphase is about $301.86. Use a free SingleCare Premphase coupon at participating pharmacies such as Walgreens, Walmart or CVS to reduce your out-of-pocket cost to $229.63.
The retail price of Premphase without insurance is approximately $301.86 however you can receive a discounted price of $229.63 per 1, 28 tablets disp pack when using our free SingleCare discount card. Check with your pharmacist for the best pricing options.
The average copay varies depending on your health insurance coverage but you can use your SingleCare savings card to pay $229.63 and save money on your Premphase prescription.
Medicare Part D and Medicare Advantage plans cover this drug. SingleCare may be less expensive than Medicare so be sure to ask your pharmacist to check your SingleCare discount card to compare prices.
There is currently no generic version of Premphase available on the market. The drug's manufacturer is Wyeth Pharmaceuticals Inc.
Premphase (conjugated estrogens-medroxyprogesterone) is a prescription drug that is composed of estrogen/progestin that is used as a hormone replacement in menopausal women who still have their uterus to treat hot flashes and prevent osteoporosis (bone loss). This drug is slightly less popular than other estrogen-progestin combinations. There are currently no generic alternatives to Premphase.
Premphase is taken orally and should be taken at the same time each day. The 28-day Premphase treatment consists of two different colored pills, 14 of each color. Be sure to carefully follow the patient's instructions about which pills to take on days 1 through 14 and which pills to take on days 15 through 28. Check with your doctor on a regular basis to determine whether you should continue this treatment.
This drug should not be taken if you have undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you are about to undergo major surgery, or if you have ever had a heart attack, blood clot, stroke, or cancer of the breast, uterus/cervix or vagina. If you are pregnant, do not use Premphase. When using Premphase, it may increase the risk of developing a condition that can lead to uterine and breast cancer. Report to your doctor if you experience any unusual vaginal bleeding right away.
Some side effects of Premphase may occur such as back pain, depression, bloating, lack, or loss of strength. These side effects may go away during treatment as your body adjusts to the medicine. Your doctor may be able to tell you about ways that you can prevent or reduce some of the commonly reported side effects. Less common side effects include blemishes on the skin, body aches or pain, congestion, muscle pain or stiffness, pain in the joints, pain or tenderness around the eyes and cheekbones, hair loss or thinning of the hair, leg cramps, loss of bladder control, trouble with sleeping, vaginal discharge that is clear or white and rapidly changing moods.
Check with your healthcare professional if any of the following side effects persist or worsens. This is not a complete list of all possible side effects that may occur. You can report severe side effects to the FDA. Seek medical advice to find out if this drug is right for you.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved