Premphase Coupons & Prices

Premphase is a combination prescription drug used for the treatment of menopause symptoms such as hot flashes and vaginal changes. It can also be used to prevent osteoporosis (bone loss) in menopausal women. There is currently no generic version of Premphase available. The average cost of Premphase is about $301.86. Use a free SingleCare Premphase coupon at participating pharmacies such as Walgreens, Walmart or CVS to reduce your out-of-pocket cost to $229.63.

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1 disp pack28 tabletsEdit

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Premphase coupon at Walgreens Pharmacy
$232.63
$ 229.63
$3 off with signupwith signup

Show this free card to your pharmacist.

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Premphase coupon at Kroger Pharmacy
$233.64
$ 230.64
$3 off with signupwith signup

Save an extra $3 on any eligible prescription! Sign up for free

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Premphase coupon at Harris Teeter Pharmacy
$233.64
$ 230.64
$3 off with signupwith signup
Premphase coupon at Walmart Neighborhood Market Pharmacy
$243.09
$ 240.09
$3 off with signupwith signup
Premphase coupon at Walmart Pharmacy
$243.09
$ 240.09
$3 off with signupwith signup
Premphase coupon at Costco Pharmacy
$244.06
$ 241.06
$3 off with signupwith signup
$244.09
$ 241.09
$3 off with signupwith signup
$252.49
$ 249.49
$3 off with signupwith signup
$ 260.56

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Premphase

Premphase is a combination prescription drug used for the treatment of menopause symptoms such as hot flashes and vaginal changes. It can also be used to prevent osteoporosis (bone loss) in menopausal women. There is currently no generic version of Premphase available. The average cost of Premphase is about $301.86. Use a free SingleCare Premphase coupon at participating pharmacies such as Walgreens, Walmart or CVS to reduce your out-of-pocket cost to $229.63.

Premphase Price History & Information

Price History for Premphase

1 count, disp pack, 28 tablets

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Premphase

1 count, disp pack, 28 tablets

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Premphase

Premphase is a combination prescription drug used for the treatment of menopause symptoms such as hot flashes and vaginal changes. It can also be used to prevent osteoporosis (bone loss) in menopausal women. There is currently no generic version of Premphase available. The average cost of Premphase is about $301.86. Use a free SingleCare Premphase coupon at participating pharmacies such as Walgreens, Walmart or CVS to reduce your out-of-pocket cost to $229.63.

Premphase FAQs

How much does Premphase cost without insurance?

The retail price of Premphase without insurance is approximately $301.86 however you can receive a discounted price of $229.63 per 1, 28 tablets disp pack when using our free SingleCare discount card. Check with your pharmacist for the best pricing options.

How much does Premphase cost with insurance?

The average copay varies depending on your health insurance coverage but you can use your SingleCare savings card to pay $229.63 and save money on your Premphase prescription.

Does Medicare cover Premphase and how much does it cost?

Medicare Part D and Medicare Advantage plans cover this drug. SingleCare may be less expensive than Medicare so be sure to ask your pharmacist to check your SingleCare discount card to compare prices.

Is there a generic of Premphase?

There is currently no generic version of Premphase available on the market. The drug's manufacturer is Wyeth Pharmaceuticals Inc.

What is Premphase?

Premphase (conjugated estrogens-medroxyprogesterone) is a prescription drug that is composed of estrogen/progestin that is used as a hormone replacement in menopausal women who still have their uterus to treat hot flashes and prevent osteoporosis (bone loss). This drug is slightly less popular than other estrogen-progestin combinations. There are currently no generic alternatives to Premphase.

Premphase is taken orally and should be taken at the same time each day. The 28-day Premphase treatment consists of two different colored pills, 14 of each color. Be sure to carefully follow the patient's instructions about which pills to take on days 1 through 14 and which pills to take on days 15 through 28. Check with your doctor on a regular basis to determine whether you should continue this treatment.

This drug should not be taken if you have undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you are about to undergo major surgery, or if you have ever had a heart attack, blood clot, stroke, or cancer of the breast, uterus/cervix or vagina. If you are pregnant, do not use Premphase. When using Premphase, it may increase the risk of developing a condition that can lead to uterine and breast cancer. Report to your doctor if you experience any unusual vaginal bleeding right away.

What are the side effects of Premphase?

Some side effects of Premphase may occur such as back pain, depression, bloating, lack, or loss of strength. These side effects may go away during treatment as your body adjusts to the medicine. Your doctor may be able to tell you about ways that you can prevent or reduce some of the commonly reported side effects. Less common side effects include blemishes on the skin, body aches or pain, congestion, muscle pain or stiffness, pain in the joints, pain or tenderness around the eyes and cheekbones, hair loss or thinning of the hair, leg cramps, loss of bladder control, trouble with sleeping, vaginal discharge that is clear or white and rapidly changing moods.

Check with your healthcare professional if any of the following side effects persist or worsens. This is not a complete list of all possible side effects that may occur. You can report severe side effects to the FDA. Seek medical advice to find out if this drug is right for you.

Where are Premphase coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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