Twinrix is an FDA-approved recombinant vaccine used to prevent hepatitis A and hepatitis B infection. It is manufactured by GlaxoSmithKline and produced through recombinant DNA methods to provide immunity against these infections. Twinrix is recommended for people who are not already immune or at an increased risk of getting these infections, such as healthcare personnel. Twinrix is administered as an intramuscular injection. A generic version of Twinrix is not available.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 02/03/2026
Twinrix is an FDA-approved recombinant vaccine used to prevent hepatitis A and hepatitis B infection. It is manufactured by GlaxoSmithKline and produced through recombinant DNA methods to provide immunity against these infections. Twinrix is recommended for people who are not already immune or at an increased risk of getting these infections, such as healthcare personnel. Twinrix is administered as an intramuscular injection. A generic version of Twinrix is not available.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Twinrix Retail Price | Twinrix SingleCare Price |
|---|---|---|
| CVS Pharmacy | $208.99 | $167.96 |
| Walmart | $158.62 | $158.62 |
| Walgreens | $197.99 | $179.19 |
| Kroger Pharmacy | $160.00 | $160.00 |
| Albertsons Pharmacy | $196.43 | $150.00 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Twinrix is an FDA-approved recombinant vaccine used to prevent hepatitis A and hepatitis B infection. It is manufactured by GlaxoSmithKline and produced through recombinant DNA methods to provide immunity against these infections. Twinrix is recommended for people who are not already immune or at an increased risk of getting these infections, such as healthcare personnel. Twinrix is administered as an intramuscular injection. A generic version of Twinrix is not available.
Twinrix costs an average retail price of $214.02. A SingleCare prescription discount card may help reduce the cost of Twinrix without insurance. However, the discount card may not cover administration fees.
Twinrix is usually covered by insurance plans. However, the copay for Twinrix varies by health insurance plan. You can check with your pharmacist or healthcare provider to calculate your copay with insurance coverage. You can reduce your Twinrix cash price to $130.99 at participating pharmacies.
Medicare typically covers Twinrix. The typical copay for Twinrix ranges between $0 and $334, depending on where you get it from. You may be able to use SingleCare to save on the cost of the vaccine.
Twinrix is a brand-name vaccine. The drug manufacturer is GlaxoSmithKline. The generic name of Twinrix is Hepatitis A and Hepatitis B Recombinant Vaccine, but there is not a generic version of Twinrix available.
Twinrix is a combination vaccine that is used to prevent infections from the hepatitis A and hepatitis B viruses. Hepatitis A and hepatitis B can lead to complications like liver failure, liver cancer, and death. Twinrix contains an inactivated form of the hepatitis A virus and a synthetic part of the hepatitis B virus to produce immunity through antibody production. This vaccine does not contain a live virus.
Twinrix is administered as an injection into the muscle by a doctor or healthcare professional. Adults and children usually receive the injection in the upper arm, and infants receive it in the upper thigh. Your healthcare provider will give you a vaccination schedule, which is usually over a six-month period through a series of three injections.
Talk to your doctor and pharmacist about all of the drugs you use including prescription and over-the-counter medications. Inform your healthcare provider of any health problems you may have, especially if you have a weakened immune system or allergies. Talk to your doctor or pharmacist for medical advice.
Common side effects of Twinrix include soreness or redness around the site of injection, headache, and fatigue. Other side effects may include diarrhea, nausea, fever, dizziness, weakness, and abdominal pain.
There are reports of fainting after Twinrix is administered. Allergic reactions are also possible and may include signs or symptoms such as severe rash, itching, swelling of the face or throat, and difficulty breathing.
This is not a complete list of side effects. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions. You can report negative side effects to the FDA.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2026 SingleCare Administrators. All rights reserved