Twyneo Coupons & Prices

Twyneo is a Acne Combinations class prescription created by Mayne Pharma. The typical cash price of Twyneo is $1,318.99 per 1, 30gm of 0.1-3% pump btl, but you can pay $451.96 for 1, 30gm of 0.1-3% pump btl of Twyneo when you use a SingleCare savings card.

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1 pump btl30gm of 0.1-3%Edit

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Twyneo coupon at Walgreens Pharmacy
$454.96
$ 451.96
$3 off with signupwith signup

Show this free card to your pharmacist.

This coupon is not insurance.
Twyneo coupon at Kroger Pharmacy
$794.98
$ 791.98
$3 off with signupwith signup
Twyneo coupon at Harris Teeter Pharmacy
$794.98
$ 791.98
$3 off with signupwith signup
Twyneo coupon at CVS Pharmacy
$847.82
$ 844.82
$3 off with signupwith signup
Twyneo coupon at Publix Pharmacy
$849.28
$ 846.28
$3 off with signupwith signup
Twyneo coupon at Walmart Neighborhood Market Pharmacy
$863.89
$ 860.89
$3 off with signupwith signup
$863.89
$ 860.89
$3 off with signupwith signup
$869.08
$ 866.08
$3 off with signupwith signup
$ 977.00

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 04/17/2026

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4.8 average rating
About Twyneo

Twyneo is a Acne Combinations class prescription created by Mayne Pharma. The typical cash price of Twyneo is $1,318.99 per 1, 30gm of 0.1-3% pump btl, but you can pay $451.96 for 1, 30gm of 0.1-3% pump btl of Twyneo when you use a SingleCare savings card.

Twyneo Price History & Information

Price History for Twyneo

1 count, pump btl, 30gm of 0.1-3%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Twyneo

1 count, pump btl, 30gm of 0.1-3%
PharmacyTwyneo Retail PriceTwyneo SingleCare Price
CVS Pharmacy$851.55$669.00
Walmart$865.20$664.80

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Twyneo

Twyneo is a Acne Combinations class prescription created by Mayne Pharma. The typical cash price of Twyneo is $1,318.99 per 1, 30gm of 0.1-3% pump btl, but you can pay $451.96 for 1, 30gm of 0.1-3% pump btl of Twyneo when you use a SingleCare savings card.

Twyneo FAQs

How much is Twyneo with SingleCare?

Twyneo costs $451.96 for 1, 30gm of 0.1-3% pump btl with a free Twyneo coupon from SingleCare.  But, you could lower this cost more depending on your Rx details. Use the dropdown menu above to update your prescription information (i.e., generic/brand, quantity, dosage, form) to find the most accurate price of Twyneo with SingleCare at a pharmacy near you.

How much does Twyneo cost without insurance?

The average out-of-pocket cost of Twyneo without health insurance is $1,318.99 per 1, 30gm of 0.1-3% pump btl though you can save using a SingleCare Twyneo coupon to pay $451.96 for 1, 30gm of 0.1-3% pump btl of Twyneo. People without access to insurance can always use SingleCare for free Twyneo savings.

How much does Twyneo cost with insurance?

Every individual insurance formulary has different details and may or may not cover Twyneo. The cost of Twyneo with insurance coverage differs based on your plan - reach out to your insurance carrier for definitive prescription coverage and coinsurance guidance. If your plan does not offer coverage for Twyneo, you can use a SingleCare card to get a better rate on Twyneo at your participating pharmacy. In addition, you can also use SingleCare cards if you have Medicare or Medicaid. When Medicare or Medicaid doesn’t cover your Twyneo fill, use SingleCare instead. Visit the SingleCare website or app to find the lowest price of Twyneo with SingleCare versus your Twyneo copay with insurance or Medicare.

Is generic Twyneo available?

Twyneo is a branded prescription made by Mayne Pharma. There is no generic version of Twyneo available at this time.

How to use SingleCare for Twyneo

SingleCare coupons are accepted at most major pharmacies and grocery stores, such as Walgreens, Kroger, Walmart, CVS, Safeway, and more. Simply text, email, print, or save your free Twyneo coupon to your digital wallet and show a pharmacist at checkout. 

Where are Twyneo coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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