Hydrocodone-Acetaminophen is a generic prescription medication. It is a combination medication opioid drug known by common brand names such as Lortab, Vicodin, and Norco. Hydrocodone is an opioid that works by interrupting pain signals to the brain and altering the perception of pain. Acetaminophen is a non-opioid pain reliever and fever reducer. The retail price for Hydrocodone-Acetaminophen is $24.88 for 12, 5mg/325mg tablets, but a SingleCare Hydrocodone-Acetaminophen coupon may help reduce the cash price of the prescription to $12.14 for 12, 5mg/325mg tablets at major pharmacies nationwide.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Hydrocodone-Acetaminophen is a generic prescription medication. It is a combination medication opioid drug known by common brand names such as Lortab, Vicodin, and Norco. Hydrocodone is an opioid that works by interrupting pain signals to the brain and altering the perception of pain. Acetaminophen is a non-opioid pain reliever and fever reducer. The retail price for Hydrocodone-Acetaminophen is $24.88 for 12, 5mg/325mg tablets, but a SingleCare Hydrocodone-Acetaminophen coupon may help reduce the cash price of the prescription to $12.14 for 12, 5mg/325mg tablets at major pharmacies nationwide.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Hydrocodone-Acetaminophen Retail Price | Hydrocodone-Acetaminophen SingleCare Price |
|---|---|---|
| CVS Pharmacy | $22.12 | $21.84 |
| Walmart | $19.68 | $12.84 |
| Walgreens | $20.40 | $14.88 |
| Kroger Pharmacy | $18.99 | $11.82 |
| Albertsons Pharmacy | $17.64 | $10.56 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Hydrocodone-Acetaminophen is a generic prescription medication. It is a combination medication opioid drug known by common brand names such as Lortab, Vicodin, and Norco. Hydrocodone is an opioid that works by interrupting pain signals to the brain and altering the perception of pain. Acetaminophen is a non-opioid pain reliever and fever reducer. The retail price for Hydrocodone-Acetaminophen is $24.88 for 12, 5mg/325mg tablets, but a SingleCare Hydrocodone-Acetaminophen coupon may help reduce the cash price of the prescription to $12.14 for 12, 5mg/325mg tablets at major pharmacies nationwide.
Prescription prices are about $24.88 for 12, 5mg/325mg tablets of Hydrocodone-Acetaminophen without health insurance, but only $12.14 for 12, 5mg/325mg tablets with a SingleCare Hydrocodone-Acetaminophen coupon.
The co-pay for Hydrocodone-Acetaminophen will vary depending on your insurance plan. With SingleCare discount cards or discount coupons, Hydrocodone-Acetaminophen costs $12.14 for 12, 5mg/325mg tablets, so you should ask your pharmacist to compare your SingleCare price with your insurance copay. A SingleCare savings card typically saves you up to 80% off on your prescription drugs, which may be lower than your copay. You can always contact your insurance provider for pricing estimates and the most recent pricing information.
Medicare prescription plans may not cover brand-name versions of Hydrocodone-Acetaminophen. Check your plan for coverage details. For patients without Medicare coverage, a SingleCare Hydrocodone-Acetaminophen prescription discount card could help lower the cost to $12.14 for 12, 5mg/325mg tablets at participating pharmacies.
Hydrocodone-Acetaminophen is a generic prescription drug made by many different generic manufacturers. Brand-name Hydrocodone-Acetaminophen is available as several brand names including Lortab liquid or Norco tablets.
Take Hydrocodone-Acetaminophen exactly as directed. Do not take higher doses of this medication than prescribed, and do not take it for longer than prescribed. Tell your doctor if you feel the urge to use more medicine. An overdose can cause death.
Do not drink alcohol while taking this medication. Also, do not drive while taking this medication. Before taking Hydrocodone-Acetaminophen, review your medication list with your health care provider. This includes prescription and OTC drugs, vitamins, and supplements. Hydrocodone-Acetaminophen should not be combined with certain drugs such as anxiety medications, sleep medications, or muscle relaxants. Always check with your healthcare professional before starting any new medicines while taking Hydrocodone-Acetaminophen.
Never share Hydrocodone-Acetaminophen with anyone else. Misuse of opioids such as Hydrocodone-Acetaminophen can cause addiction, overdose, and death. Store this medication where no one else can get to it, and keep track of your pills so you know if any are missing. If you take the liquid formulation, measure carefully with a dosing syringe or medication measuring device. Do not use kitchen spoons to measure medication.
You should not keep any leftover medication. One dose can cause death in someone who uses this medicine accidentally or improperly. Ask your pharmacist about a drug take-back disposal program.
Hydrocodone is an opioid, so commonly experienced side effects will include drowsiness, dizziness, nausea, vomiting, constipation, and lightheadedness.
Hydrocodone-Acetaminophen may also cause mental clouding, mental impairment, trouble concentrating, loss of coordination, anxiety, fear, and mood changes.
Consult your healthcare provider if side effects develop, persist, or worsen.
Hydrocodone-Acetaminophen is a Schedule II drug, according to the DEA. It carries a high risk of abuse, misuse, and addiction. An overdose on Hydrocodone-Acetaminophen may cause slowed breathing, low blood pressure, extreme drowsiness, coma, or death. Family members and friends should be alert to slowed or shallow breathing, or if you are difficult to wake up, and they should seek emergency help if needed.
Allergic reactions are rare. Seek immediate medical attention if you experience signs of an allergic reaction such as rash, swelling, or trouble breathing after taking Hydrocodone-Acetaminophen.
Hydrocodone-Acetaminophen can cause serious skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis. These conditions are dangerous and life-threatening skin reactions that can cause death if not treated. Get emergency medical help if you have a fever, sore throat, burning eyes, skin pain, red or purple rash, or blistering or peeling skin.
Tell your healthcare professional if you have a history of seizures, head injury, problems urinating, substance abuse disorder, or liver, kidney, gallbladder, thyroid, or pancreas problems before taking Hydrocodone-Acetaminophen. Consult a healthcare provider for other possible side effects, warnings, and precautions before taking Hydrocodone-Acetaminophen.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved