{Combipatch (estradiol-norethindrone) is a prescription medication used to treat symptoms of menopause like hot flashes, night sweats, and vaginal dryness in menopausal women who have a uterus. It is also used in women with a uterus who are not menopausal but do not make enough estrogen for other reasons. Combipatch is a transdermal hormone therapy patch manufactured by the pharmaceutical company Noven Pharmaceuticals.The cost of Combipatch is about $379.14 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box but you can use a Combipatch coupon and pay a discounted price of $242.39 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/18/2025
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{Combipatch (estradiol-norethindrone) is a prescription medication used to treat symptoms of menopause like hot flashes, night sweats, and vaginal dryness in menopausal women who have a uterus. It is also used in women with a uterus who are not menopausal but do not make enough estrogen for other reasons. Combipatch is a transdermal hormone therapy patch manufactured by the pharmaceutical company Noven Pharmaceuticals.The cost of Combipatch is about $379.14 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box but you can use a Combipatch coupon and pay a discounted price of $242.39 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Combipatch Retail Price | Combipatch SingleCare Price |
|---|---|---|
| CVS Pharmacy | $310.00 | $247.28 |
| Walmart | $289.07 | $244.66 |
| Walgreens | $304.96 | $277.44 |
| Kroger Pharmacy | $312.48 | $245.36 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
{Combipatch (estradiol-norethindrone) is a prescription medication used to treat symptoms of menopause like hot flashes, night sweats, and vaginal dryness in menopausal women who have a uterus. It is also used in women with a uterus who are not menopausal but do not make enough estrogen for other reasons. Combipatch is a transdermal hormone therapy patch manufactured by the pharmaceutical company Noven Pharmaceuticals.The cost of Combipatch is about $379.14 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box but you can use a Combipatch coupon and pay a discounted price of $242.39 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box.
1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box of Combipatch costs about $379.14 but Combipatch coupons can help you to reduce your prescription costs. You can use a discount card from SingleCare to receive a prescription discount and pay our lowest price of $242.39 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box. Access the SingleCare website and start saving today. Anyone in the United States with a valid prescription can use SingleCare. There are no other eligibility requirements.
Your copay for Combipatch will depend on your insurance plan. Your pharmacist or insurance provider can advise you about your copay for Combipatch.
SingleCare may help you to save more money on your prescription medicines than your insurance coverage. At a participating pharmacy, you can ask the pharmacist to apply your savings card to compare pricing.
Medicare prescription plans do not typically cover Combipatch. However, you can use your SingleCare Combipatch coupon at participating pharmacies to receive your prescription at a reduced cost. SingleCare's coupons and cards for Combipatch can lower the retail price to $242.39 for 1, 1 box (8 twice weekly patches), 0.05-0.14mg/day box.
Combipatch is a brand-name drug. Currently, there is no generic version of Combipatch commercially available.
Combipatch is a prescription drug that is used to relieve menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. Menopause is the time that marks the end of menstrual cycles, and is the end of the reproductive period. During menopause, the ovaries do not produce eggs and menstruation stops. If you are experiencing menopause, you can lack estrogen and progesterone in your body. Also, some younger, premenopausal women do not make enough estrogen for various reasons and need to use Combipatch for hormone replacement.
Combipatch is a hormone therapy that supplies the body with estradiol (estrogen) and norethindrone acetate (progestin). These two active ingredients provide a continuous release of female hormones to relieve menopausal symptoms. The patch is placed on the lower abdomen and changed twice weekly. Together, the hormones help to reduce hot flashes, treat menopausal changes in and around the vagina, and treat certain conditions in women before menopause when their ovaries do not make enough estrogen.
Combipatch should not be used to prevent heart disease, stroke, or dementia. Combipatch can increase the risk of blood clots, stroke, heart attack, or certain cancers (cancer of the breast, ovaries, or uterus).
Combipatch should only be used by women who have their uterus. There are various hormone therapy options for you to consider. Seek medical advice from a healthcare professional who can determine if this medication is right for you.
Some common side effects of Combipatch are headaches, breast pain, nausea, vaginal yeast infections, vaginal bleeding or spotting, and abdominal cramps or bloating. You may notice changes in weight, mood, and sex drive. It is important to note that this is not a full list of side effects that can occur when using Combipatch. Ask a healthcare provider for complete drug information before taking Combipatch.
Some serious side effects that can possibly occur when using Combipatch include blood clots, stroke, breast cancer, depression, dementia, and heart attack. Before using Combipatch, you should talk to your health care provider about the risks and benefits.
Severe allergic reactions are rare but require emergency medical help. Be alert to symptoms like hives, difficulty breathing, and swelling of the face, lips, tongue, or throat, and get immediate medical attention if these symptoms occur.
There are other serious effects that patients should be aware of before using Combipatch. You should talk to your healthcare provider as soon as possible if you experience any of the listed side effects. If you experience other abnormal bodily changes, you should inform your healthcare provider to ensure this medication will not harm your health.
Talk with your healthcare provider about how long you should stay on Combipatch. Many people need to take hormone therapy for two to seven years.
You may start to notice an improvement in menopause symptoms after several weeks. It may take up to several months to feel the full benefit of this medication.
There are various alternatives to Combipatch, including combination estrogen and progesterone as well as estrogen-only medications. There are also various dosage forms, including vaginal rings, vaginal tablets, vaginal creams, oral medications, and other patches. Consult your healthcare provider to determine which medication is appropriate for you.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved