Wegovy (semaglutide) is a once-a-week injectable prescription drug for weight loss, used in conjunction with diet and exercise, approved by the U.S. Food and Drug Administration (FDA) for use in adult patients who have a body mass index (BMI) of 30 kg/m2 or greater or a BMI of 27 kg/m2 or more and have at least one health condition (e.g., high blood pressure or Type 2 diabetes) related to body weight. Wegovy carries a boxed warning, also known as a black box warning, stating that people who have a history or family history of medullary thyroid cancer or those with multiple endocrine neoplasia syndrome type 2 (MEN 2) should not take Wegovy.
Wegovy
Semaglutide
Wegovy is a glucagon-like peptide-1 receptor agonist (GLP-1 agonist) that aids in long-term weight loss.
Weight loss drug
Pre-filled single-dose injectable pen
By injection
Wegovy is a prescription drug made by Novo Nordisk approved for weight loss.
Key takeaways
Wegovy is a once-a-week subcutaneous injection medicine FDA-approved for chronic weight management in adults who have a body mass index (BMI) of 30 kg/m2 or greater or a BMI of 27 kg/m2 or more and have at least one health condition, such as high blood pressure or Type 2 diabetes, related to their weight.
Wegovy should be used in conjunction with lifestyle changes that include a reduced-calorie diet plan and increased physical activity.
You should receive an informative Wegovy Medication Guide from your pharmacist; the medication guide is also available online.
Wegovy may cause serious side effects that include thyroid tumors; it should not be used if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called multiple endocrine neoplasia syndrome type 2 (MEN 2).
Wegovy is a premium-priced drug that could cost up to $20,000 a year.
Pre-filled single-dose pen-injector
Pen 0.5 ml of 0.25 mg/0.5 ml
Pen 0.5 ml of 0.5 mg/0.5 ml
Pen 0.5 ml of 1 mg/0.5 ml
Pen 0.75 ml of 1.7 mg/0.75 ml
Pen 0.75ml of 2.4 mg/0.75 ml
Wegovy is given once each week, on the same day. It starts with 0.25 mg in the first month, increases to 0.5 mg in the second month, 1 mg in the third month, and 1.7 mg in the fourth month; from the fifth month on, the full dose of 2.4 mg is given weekly.
Wegovy
0.5ml prefilled 0.25mg/0.5ml pen pen
Wegovy
0.5ml prefilled 0.5mg/0.5ml pen pen
Wegovy
0.5ml prefilled 1mg/0.5ml pen pen
Wegovy
0.75ml prefilled 1.7mg/0.75ml pen pen
Wegovy
0.75ml prefilled 2.4mg/0.75ml pen pen
Your healthcare provider should show you how to use the Wegovy pen before you use it for the first time.
Wegovy is injected under the skin (subcutaneously) of your stomach, thigh, or upper arm.
The Wegovy pen is for one-time use only. The dose is already set on the pen.
The needle is covered by the needle cover, and the needle will not be seen.
Do not remove the pen cap until you are ready to inject.
The Wegovy injection will begin when the needle cover is pressed against your skin.
Do not remove the pen from your skin before the yellow bar in the pen window has stopped moving. If the needle is removed earlier, you may not get your full dose of Wegovy.
The needle cover will lock when the pen is removed from your skin. You cannot stop the injection and restart it later.
Rotate your injection site after each injection. Do not use the same site for each injection.
Use Wegovy once each week, on the same day each week, at any time of the day.
Wegovy can be taken with or without food.
Store the Wegovy pen in the refrigerator; do not freeze.
Keep Wegovy in the original carton to protect it from light.
Do not use your Wegovy pen if:
the pen appears to have been used, or any part of the pen appears broken (e.g., if it has been dropped), or
the Wegovy medicine is not clear and colorless through the pen window, or
the expiration date (EXP) has passed.
If you miss a dose of Wegovy and the next scheduled dose is more than two days away (48 hours), take the missed dose as soon as possible.
If you miss a dose of Wegovy and the next scheduled dose is less than two days away (48 hours), do not administer the dose. Take your next dose on the regularly scheduled day.
If you miss doses of Wegovy for more than two weeks, take your next dose on the regularly scheduled day or call your healthcare provider to talk about how to restart your treatment.
Do not use Wegovy if:
You or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called multiple endocrine neoplasia syndrome type 2 (MEN 2), or
You have had a serious allergic reaction to the active ingredient semaglutide or any of the ingredients in Wegovy.
Before using Wegovy, tell your healthcare provider if you have any other medical conditions, including if you:
Have had problems with your pancreas or kidneys, or
Have type 2 diabetes mellitus and a history of diabetic retinopathy, or
Have had depression, suicidal thoughts, mental health issues, or
Are pregnant or plan to become pregnant, or
Are breastfeeding or plan to breastfeed.
Tell your healthcare provider about all the medications you take, including prescription and over-the-counter (OTC) medicines, vitamins, and herbal supplements. Do not use Wegovy with other semaglutide-containing products such as Ozempic. Wegovy may affect the way some medicines work, and some medicines may affect the way Wegovy works.
If you are taking other drugs to treat diabetes, such as sulfonylureas or insulin, the risk of hypoglycemia (low blood sugar levels) is increased.
Wegovy slows stomach emptying and may affect other medicines that need to pass through the stomach quickly.
The most common side effects of Wegovy include:
Nausea
Stomach pain
Dizziness
Stomach flu
Diarrhea
Headache
Feeling bloated
Heartburn
Vomiting
Fatigue
Burping
Constipation
Upset stomach
Gas
Potential serious side effects include:
Possible thyroid tumors, including cancer
Inflammation of the pancreas (pancreatitis)
Increased risk of low blood sugar (hypoglycemia)
Kidney problems (kidney failure)
Change in vision in people with type 2 diabetes
Increased heart rate
Depression or thoughts of suicide
You should contact your healthcare provider if you experience any of the following symptoms:
Severe pain in your stomach area that will not go away, with or without vomiting
Yellowing of skin or eyes (jaundice)
Fever
Clay-colored stools
Changes in vision
Marissa Walsh, Pharm.D., BCPS-AQ ID, graduated with her Doctor of Pharmacy degree from the University of Rhode Island in 2009, then went on to complete a PGY1 Pharmacy Practice Residency at Charleston Area Medical Center in Charleston, West Virginia, and a PGY2 Infectious Diseases Pharmacy Residency at Maine Medical Center in Portland, Maine. Dr. Walsh has worked as a clinical pharmacy specialist in Infectious Diseases in Portland, Maine, and Miami, Florida, prior to setting into her current role in Buffalo, New York, where she continues to work as an Infectious Diseases Pharmacist in a hematology/oncology population.
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