What is Wixela Inhub? Uses, warnings & side effects

Follow all the instructions given by the prescriber. 

Please read the Patient Information sheet and Instructions for Use that come with this medicine. 

Take two doses daily.

• Take each dose at the same time every day.

• Take doses 12 hours apart.

The inhaler contains 60 doses, enough medicine for 30 days. The dose counter will initially read “60.”

Only remove the inhaler from its pouch when ready to take the first dose.

When taking a dose: 

• Open the inhaler by first lowering the mouthpiece cover. Then pull the yellow lever all the way down until it clicks. The dose is now ready to be inhaled.

• Do not move the lever or close the cover until ready to take a dose.

• Facing away from the inhaler, breathe out as much as possible. 

• Hold the inhaler by the back in a vertical position with the opened cover facing down.

• Place the mouthpiece between your lips.

• Breathe in quickly and deeply.

• Remove the mouthpiece from your mouth and hold your breath for 10 seconds.

• Breathe out slowly for as long as you can.

• Do not take another dose.

• Close the mouthpiece. This will automatically push the yellow lever back to its original position.

• Rinse your mouth out with water and spit it out.

Do not wash the inhaler.

Throw the empty inhaler away when the dose count reaches “0” or one month has passed since it was removed from its pouch.

Store the inhaler at room temperature in a dry place away from heat and direct sunlight.

If a dose is missed, skip it.

Take the next dose at its regular time. 

Do not take an extra dose to make up for a missed dose.

This medicine is not right for everyone. 

Do not use it if you have had an allergic reaction to salmeterol, fluticasone, or milk proteins.

Tell all doctors and other healthcare providers treating you about Wixela Inhub.

Regular visits are required to monitor therapy and progress. Keep all appointments.

Before using Wixela Inhub, tell the doctor if you are pregnant or breastfeeding, or if you have:

• Heart problems

• High blood pressure

• Seizures

• Diabetes

• Liver problems

• Thyroid problems

• Immune system problems

• Weak bones (osteoporosis)

• Any current or past eye problems such as cataracts, glaucoma, high eye pressure, or vision changes

• Any active viral, bacterial, or fungal infection

• Exposure to chickenpox or measles

Wixela Inhub can cause serious problems, including:

• Increased risk of asthma-related hospital stays, intubations, and death

• Sudden airway closure and breathing problems right after a dose

• Weakened immune system

• Infections

• Pneumonia (in COPD patients)

• Fungal infection of the mouth

• Cataracts

• Glaucoma

• High blood pressure

• Abnormal heart rhythms

• Chest pain

• Seizures

• Reduced adrenal gland function

• Bone thinning or weakness

• Low potassium

• Increases in blood sugar levels

• Stunted growth (in children)

This medicine will not stop an active exacerbation. Always carry a rescue inhaler in case of an acute asthma attack or COPD exacerbation. 

Contact the prescriber if your condition worsens, which is usually indicated by more frequent use of a rescue inhaler. The healthcare provider may need to increase the dose or switch you to oral corticosteroids.

Do not use Wixela Inhub with other inhaled medicines that contain drugs similar to salmeterol called long-acting beta agonists (LABAs). These include formoterol, indacaterol, and vilanterol. 

To avoid potentially hazardous drug interactions, tell the prescribing healthcare provider about all drugs regularly used, particularly:

• Monoamine oxidase inhibitors (MAOIs)

• Tricyclic antidepressants

• Beta blockers

• Drugs that make you urinate (diuretics)

• Azole antifungal drugs, particularly ketoconazole

• Antiviral drugs called protease inhibitors, particularly ritonavir

• Clarithromycin, nefazodone, Paxlovid, telithromycin

Avoid grapefruit juice when taking Wixela Inhub.

People who switch to Wixela Inhub from oral corticosteroids may experience steroid withdrawal. If this happens, the prescriber may need to restart oral corticosteroids. 

Do not start any new medications until talking to the prescriber.