What is Xdemvy? Uses, warnings & side effects
XDEMVY is a topical ophthalmic drug (eye drop) that contains the active ingredient lotilaner. It is used for the treatment of Demodex blepharitis, a common eye disease caused by an infestation of Demodex mites, the most common ectoparasite found on human skin. XDEMVY is a brand-name medication made by the drug company Tarsus Pharmaceuticals. After being studied in clinical trials that showed significant improvement in symptoms, XDEMVY was approved by the U.S. Food and Drug Administration (FDA) in July 2023. XDEMVY is the first (and only) medication to receive FDA approval for this condition, targeting the root cause of Demodex blepharitis, according to a press release by Tarsus Pharmaceuticals.
Xdemvy overview
BRAND NAMES:
XDEMVY
Generic Names:
The active ingredient of XDEMVY is called lotilaner, but there is no generic version available for sale
Uses:
XDEMVY treats Demodex blepharitis
Therapeutic Classes:
XDEMVY is classified as an ectoparasiticide or an anti-parasitic drug.
More specifically, it is classified as a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor that works against mites.
Forms:
Ophthalmic solution
How it’s taken:
An eye drop administered into the eyes
What is Xdemvy used for?
XDEMVY is FDA-approved to treat Demodex blepharitis. Demodex blepharitis is a common eye condition caused by a type of parasite called Demodex mites. Demodex mites are parasites commonly found on human skin. Signs and symptoms of Demodex blepharitis include eyelid redness, irritation, swelling, and misdirected eyelashes as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can cause irritation, eyelash distension or loss, and swelling, which can be uncomfortable. Demodex blepharitis should only be diagnosed and treated by an eye care professional.
Key takeaways
The dose of XDEMVY is one drop in each eye twice a day, about 12 hours apart, for six weeks.
Remove contact lenses before putting in XDEMVY eye drops. You can put your contact lenses back in 15 minutes after you put in the eye drops.
If you are using other eye medications, wait at least five minutes between using XDEMVY and any other eye medications.
Use caution not to contaminate the tip of the bottle, as doing so could lead to damage to the eye and vision loss.
While using XDEMVY, you may experience eye stinging and burning. If side effects are severe, consult your physician for medical advice.
What form(s) does Xdemvy come in?
Ophthalmic solution (eye drop)
0.25% lotilaner
What are common Xdemvy dosages?
To treat Demodex blepharitis, the adult dose of XDEMVY is one drop in each eye twice a day (about 12 hours apart) for six weeks.
XDEMVY is not approved for use in children and adolescents younger than 18 years old.
Xdemvy images - What does Xdemvy look like?
Xdemvy
10ml of 0.25% bottle
How to take Xdemvy
The dose of XDEMVY is one drop in each eye twice a day, about 12 hours apart, for six weeks.
Remove contact lenses before putting in XDEMVY eye drops. You can put your contact lenses back in 15 minutes after you put in the eye drops.
If you are using other eye medications, wait at least five minutes between using XDEMVY and any other eye medications.
Use caution not to contaminate the tip of the bottle, as doing so could lead to damage to the eye and vision loss.
While using XDEMVY, you may experience eye stinging and burning. If side effects are severe, consult your physician for medical advice.
What to do if you miss a dose of Xdemvy
If you miss a dose of XDEMVY, skip the missed dose.
Resume treatment with the next scheduled dose.
Xdemvy contraindications - Who shouldn't take Xdemvy?
Xdemvy warnings
Contaminated XDEMVY solution can cause serious eye damage, including vision loss. Take care not to allow the tip of the dispensing container to come into contact with the eye (or around the eye), fingers, or any other surfaces. This will help minimize the chance of contamination.
XDEMVY contains a chemical additive called potassium sorbate that can discolor soft contact lenses. Remove contact lenses before putting XDEMVY eye drops in. Wait at least 15 minutes after putting your eye drops in before you reinsert contact lenses.
Call your healthcare provider right away for advice on the continued use of XDEMVY if:
You develop any other eye condition during treatment with XDEMVY (such as trauma to the eye or an eye infection)
You are having eye surgery
You have any eye reactions (like pink eye) or eyelid reactions
Xdemvy interactions & what to avoid when taking Xdemvy
XDEMVY does not have any listed drug interactions.
However, you should always tell your healthcare provider about all the medications you take, including prescription and over-the-counter drugs, vitamins, and supplements.
If you are using any other medications in your eye, wait at least five minutes between using XDEMVY and using any other medications in the eye.
Xdemvy side effects - How does Xdemvy make you feel?
Common ocular adverse reactions of XDEMVY, occurring in about 10% of patients, include ocular irritation, such as:
Eye stinging
Eye burning
Less common side effects, which occur in less than 2% of people who take XDEMVY, include:
Chalazion/hordeolum (styes)
Punctate keratitis (corneal inflammation and damage)
Sources:
XDEMVY - lotilaner ophthalmic solution, National Library of Medicine DailyMed (2023)
XDEMVY, Tarsus Pharmaceuticals (2023)
FDA Approves XDEMVY (lotilaner ophthalmic solution) 0.25% for the treatment of Demodex blepharitis, Tarsus Pharmaceuticals (2023)
FDA Approves XDEMVY for Eye Infection Caused by Mites, Formulary Watch (2023)
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