Xdemvy Coupons & Prices

Xdemvy (lotilaner ophthalmic solution) is an anti-parasitic eye drop used to treat a condition of the eye called Demodex blepharitis. Demodex blepharitis is a common inflammatory eye condition. It is caused by a type of parasite called Demodex mites, which are parasites that are commonly found on human skin. Demodex blepharitis may involve various parts of the eye, including the skin, eyelashes, eyelash follicles, and sebaceous glands. Symptoms may include red and crusty eyes, as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can only be diagnosed and treated by an eye doctor. Xdemvy was approved by the U.S. Food and Drug Administration (FDA) in July of 2023.

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Xdemvy coupon at Kroger Pharmacy
$1890.13
$ 1,887
$3 off with signupwith signup

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Xdemvy coupon at Harris Teeter Pharmacy
$1890.13
$ 1,887
$3 off with signupwith signup

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Xdemvy coupon at Publix Pharmacy
$2024.80
$ 2,022
$3 off with signupwith signup
Xdemvy coupon at Costco Pharmacy
$2045.74
$ 2,043
$3 off with signupwith signup
Xdemvy coupon at Food Lion Pharmacy
$ 2,043
Xdemvy coupon at Walgreens Pharmacy
$2053.47
$ 2,050
$3 off with signupwith signup

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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/18/2025

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About Xdemvy

Xdemvy (lotilaner ophthalmic solution) is an anti-parasitic eye drop used to treat a condition of the eye called Demodex blepharitis. Demodex blepharitis is a common inflammatory eye condition. It is caused by a type of parasite called Demodex mites, which are parasites that are commonly found on human skin. Demodex blepharitis may involve various parts of the eye, including the skin, eyelashes, eyelash follicles, and sebaceous glands. Symptoms may include red and crusty eyes, as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can only be diagnosed and treated by an eye doctor. Xdemvy was approved by the U.S. Food and Drug Administration (FDA) in July of 2023.

Xdemvy Price History & Information

Price History for Xdemvy

10 count, solution (quantity in ml), 0.25%

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Xdemvy

10 count, solution (quantity in ml), 0.25%
PharmacyXdemvy Retail PriceXdemvy SingleCare Price
Walmart$2394.00$2328.00
Walgreens$2397.20$2053.50

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Xdemvy

Xdemvy (lotilaner ophthalmic solution) is an anti-parasitic eye drop used to treat a condition of the eye called Demodex blepharitis. Demodex blepharitis is a common inflammatory eye condition. It is caused by a type of parasite called Demodex mites, which are parasites that are commonly found on human skin. Demodex blepharitis may involve various parts of the eye, including the skin, eyelashes, eyelash follicles, and sebaceous glands. Symptoms may include red and crusty eyes, as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can only be diagnosed and treated by an eye doctor. Xdemvy was approved by the U.S. Food and Drug Administration (FDA) in July of 2023.

Xdemvy FAQs

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

How much does Xdemvy cost without insurance?

According to the manufacturer's website, a limited number of pharmacies can fill a prescription for Xdemvy.

Your eye doctor can send a prescription to one of these locations, where a pharmacy staff member will contact you to process your prescription and discuss savings options. Your prescription can be delivered to your home or a local pharmacy. 

Most individuals pay $50 or less per prescription, according to the manufacturer’s website, but the price will depend on various factors such as insurance coverage and available savings options. You can reach out to Tarsus Connect for more information about saving money on Xdemvy.

How much does Xdemvy cost with insurance?

Xdemvy is not expected to be covered by commercial insurance plans until 2024 and Medicare Part D in 2025. When Xdemvy is covered by insurance, Xdemvy costs will vary by plan. Each insurance plan has a formulary, which ranks covered prescriptions in a tier system. The higher the tier, the higher the copay. Xdemvy copays with insurance will also depend on the stage of coverage you’re in.

Is there a generic of Xdemvy?

Xdemvy is a new brand-name drug. There is no generic version of Xdemvy currently available. 

Once patent forms for a new brand-name drug are filled out by the manufacturer, it can take up to about 20 years until generic versions may enter the market. 

However, because there are several years of clinical trials, by the time the brand-name drug is approved by the FDA, there are generally about seven to 12 years left on a patent until a generic may become available.

What is Xdemvy?

Xdemvy is an eye drop that contains the active ingredient lotilaner. It is classified as an ectoparasiticide, or anti-parasitic, eye medication. More specifically, it is known as a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor. 

Xdemvy treats an inflammatory eye condition called Demodex blepharitis. This condition is caused by mites that live on the human skin and can affect various parts of the eyes, including the skin, eyelashes, eyelash follicles, and sebaceous glands.  

What are the side effects of Xdemvy?

Common side effects (occurring in about 10% of people who use Xdemvy) include eye burning and irritation. 

Less common side effects (occurring in about 2% of people who use Xdemvy) may include chalazion/hordeolum (styes) and punctate keratitis (corneal inflammation and damage).

Serious side effects are not expected. However, if you experience symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, get emergency medical help right away. 

Consult your healthcare provider for more information and questions about potential side effects.

What doses of Xdemvy are available?

Xdemvy is available as an ophthalmic solution that contains lotilaner 0.25%. 

Xdemvy is only approved for use in adults. The usual dosage is one drop instilled in each eye twice a day (about 12 hours apart) for six weeks. 

Xdemvy contains a preservative called potassium sorbate, which may discolor soft contact lenses. Remove contact lenses before using Xdemvy. You can put them back in at least 15 minutes after instilling the eye drops. 

While using Xdemvy, it is important to avoid contamination. Therefore, do not allow the tip of the bottle to touch the eye, anywhere around the eye, your fingers, or any other surfaces. Contaminated solution can cause serious eye damage, which may lead to vision loss. 

If you use more than one topical eye medication, wait at least 5 minutes between using each medication. 

While using Xdemvy, contact your doctor right away if you:

  • Develop any other eye conditions, such as infection

  • Require eye surgery

  • Develop any eye reactions like pink eye or eyelid reactions

This medication is not approved for use in children or adolescents under 18 years old. If you are pregnant or breastfeeding, consult your healthcare professional for medical advice. 

Xdemvy should be stored at room temperature, away from direct light, heat, and moisture. Keep out of reach and out of sight of children. It can be used until the expiration date on the bottle.

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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Where are Xdemvy coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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