Xdemvy (lotilaner ophthalmic solution) is an anti-parasitic eye drop used to treat a condition of the eye called Demodex blepharitis. Demodex blepharitis is a common inflammatory eye condition. It is caused by a type of parasite called Demodex mites, which are parasites that are commonly found on human skin. Demodex blepharitis may involve various parts of the eye, including the skin, eyelashes, eyelash follicles, and sebaceous glands. Symptoms may include red and crusty eyes, as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can only be diagnosed and treated by an eye doctor. Xdemvy was approved by the U.S. Food and Drug Administration (FDA) in July of 2023.
Edit your dosage
1 solution (quantity in ml), 0.25%Edit
Unlock members-only prices.Free signup.
You have 0.00 in available bonus savings. Bonus savings will be automatically applied to your next eligible prescription fill.
Show this free card to your pharmacist.

Save an extra $3 on any eligible prescription! Sign up for free
Members can save even more
and it's free to join
SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/18/2025
Members save the most
Xdemvy (lotilaner ophthalmic solution) is an anti-parasitic eye drop used to treat a condition of the eye called Demodex blepharitis. Demodex blepharitis is a common inflammatory eye condition. It is caused by a type of parasite called Demodex mites, which are parasites that are commonly found on human skin. Demodex blepharitis may involve various parts of the eye, including the skin, eyelashes, eyelash follicles, and sebaceous glands. Symptoms may include red and crusty eyes, as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can only be diagnosed and treated by an eye doctor. Xdemvy was approved by the U.S. Food and Drug Administration (FDA) in July of 2023.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Xdemvy Retail Price | Xdemvy SingleCare Price |
|---|---|---|
| Walmart | $2394.00 | $2328.00 |
| Walgreens | $2397.20 | $2053.50 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Xdemvy (lotilaner ophthalmic solution) is an anti-parasitic eye drop used to treat a condition of the eye called Demodex blepharitis. Demodex blepharitis is a common inflammatory eye condition. It is caused by a type of parasite called Demodex mites, which are parasites that are commonly found on human skin. Demodex blepharitis may involve various parts of the eye, including the skin, eyelashes, eyelash follicles, and sebaceous glands. Symptoms may include red and crusty eyes, as well as the presence of eyelash collarettes, a type of dandruff that includes cells, mite eggs, and mite waste. Demodex blepharitis can only be diagnosed and treated by an eye doctor. Xdemvy was approved by the U.S. Food and Drug Administration (FDA) in July of 2023.
According to the manufacturer's website, a limited number of pharmacies can fill a prescription for Xdemvy.
Your eye doctor can send a prescription to one of these locations, where a pharmacy staff member will contact you to process your prescription and discuss savings options. Your prescription can be delivered to your home or a local pharmacy.
Most individuals pay $50 or less per prescription, according to the manufacturer’s website, but the price will depend on various factors such as insurance coverage and available savings options. You can reach out to Tarsus Connect for more information about saving money on Xdemvy.
Xdemvy is not expected to be covered by commercial insurance plans until 2024 and Medicare Part D in 2025. When Xdemvy is covered by insurance, Xdemvy costs will vary by plan. Each insurance plan has a formulary, which ranks covered prescriptions in a tier system. The higher the tier, the higher the copay. Xdemvy copays with insurance will also depend on the stage of coverage you’re in.
Xdemvy is a new brand-name drug. There is no generic version of Xdemvy currently available.
Once patent forms for a new brand-name drug are filled out by the manufacturer, it can take up to about 20 years until generic versions may enter the market.
However, because there are several years of clinical trials, by the time the brand-name drug is approved by the FDA, there are generally about seven to 12 years left on a patent until a generic may become available.
Xdemvy is an eye drop that contains the active ingredient lotilaner. It is classified as an ectoparasiticide, or anti-parasitic, eye medication. More specifically, it is known as a gamma-aminobutyric acid (GABA)-gated chloride channel inhibitor.
Xdemvy treats an inflammatory eye condition called Demodex blepharitis. This condition is caused by mites that live on the human skin and can affect various parts of the eyes, including the skin, eyelashes, eyelash follicles, and sebaceous glands.
Common side effects (occurring in about 10% of people who use Xdemvy) include eye burning and irritation.
Less common side effects (occurring in about 2% of people who use Xdemvy) may include chalazion/hordeolum (styes) and punctate keratitis (corneal inflammation and damage).
Serious side effects are not expected. However, if you experience symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, get emergency medical help right away.
Consult your healthcare provider for more information and questions about potential side effects.
Xdemvy is available as an ophthalmic solution that contains lotilaner 0.25%.
Xdemvy is only approved for use in adults. The usual dosage is one drop instilled in each eye twice a day (about 12 hours apart) for six weeks.
Xdemvy contains a preservative called potassium sorbate, which may discolor soft contact lenses. Remove contact lenses before using Xdemvy. You can put them back in at least 15 minutes after instilling the eye drops.
While using Xdemvy, it is important to avoid contamination. Therefore, do not allow the tip of the bottle to touch the eye, anywhere around the eye, your fingers, or any other surfaces. Contaminated solution can cause serious eye damage, which may lead to vision loss.
If you use more than one topical eye medication, wait at least 5 minutes between using each medication.
While using Xdemvy, contact your doctor right away if you:
Develop any other eye conditions, such as infection
Require eye surgery
Develop any eye reactions like pink eye or eyelid reactions
This medication is not approved for use in children or adolescents under 18 years old. If you are pregnant or breastfeeding, consult your healthcare professional for medical advice.
Xdemvy should be stored at room temperature, away from direct light, heat, and moisture. Keep out of reach and out of sight of children. It can be used until the expiration date on the bottle.
After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.
...SingleCare is accepted at most national pharmacies and grocers, including the following:
Health education, drug info, wellness & more
SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2025 SingleCare Administrators. All rights reserved
© 2025 SingleCare Administrators. All rights reserved