What is Yosprala? Uses, warnings & side effects

Updated May 14, 2025  •  Published Jan 25, 2023

Yosprala overview

BRAND NAMES:

  • Yosprala, Aspirin-Omeprazole

Generic Names:

  • Yosprala

Uses:

  • Prevents heart and blood vessel problems (including heart attack, stroke) in patients who need aspirin and who are at risk of developing stomach ulcers caused by aspirin.

Therapeutic Classes:

  • Platelet Aggregation Inhibitor

Forms:

  • Delayed Release Tablet

How it’s taken:

  • By mouth

What is Yosprala used for?

What form(s) does Yosprala come in?

  • Delayed Release Tablet

What are common Yosprala dosages?

  • Tablet Delayed Release 81-40mg

Yosprala images - What does Yosprala look like?

  • Yosprala
    325-40mg tablet delayed release

  • Yosprala
    81-40mg tablet delayed release

How to take Yosprala

  • Take this medicine at least 60 minutes before a meal.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Swallow the tablet whole with liquid. Do not split, chew, crush, or dissolve it.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

What to do if you miss a dose of Yosprala

Yosprala contraindications - Who shouldn't take Yosprala?

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to aspirin, omeprazole, or similar medicines.

Yosprala warnings

  • Tell your doctor if you are of Asian descent, including Filipino, Chinese, Japanese, Korean, or Taiwanese. You may need a lower dose of this medicine.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Tell your doctor if you are pregnant or breastfeeding. Do not use this medicine during the later part of a pregnancy.

  • This medicine may cause the following problems:Increased risk of bleedingStomach ulcers or bleedingKidney problemsLiver problemsIncreased risk of broken bones in the hip, wrist, or spine (more likely if used several times per day or longer than 1 year)LupusFundic gland polyps (abnormal growth in the upper part of your stomach)

  • This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.

  • This medicine may cause a delay in ovulation for women and may affect their ability to have children. If you plan to have children, talk with your doctor before using this medicine.

  • Tell your doctor if you have kidney disease, liver disease, bleeding problems, lupus, osteoporosis, stomach problems (including ulcers), or viral infections. Tell your doctor if you drink alcohol.

  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Yosprala interactions & what to avoid when taking Yosprala

  • Some foods and medicines can affect how this medicine works. Tell your doctor if you are using any of the following:Acetazolamide, atazanavir, cilostazol, citalopram, clopidogrel, cyclosporine, dasatinib, diazepam, digoxin, disulfiram, erlotinib, itraconazole, ketoconazole, mycophenolate mofetil, methotrexate, nelfinavir, nilotinib, phenytoin, probenecid, rifampin, saquinavir, St John's wort, tacrolimus, ticagrelor, valproic acidBlood pressure medicineBlood thinner (including heparin, warfarin)Diuretic (water pill)Iron supplementsNSAID pain or arthritis medicine (including celecoxib, diclofenac, ibuprofen, naproxen)Oral diabetes medicine

  • Avoid drinking too much alcohol (3 or more drinks per day) while using this medicine.

  • Do not use this medicine if you are also using medicines containing rilpivirine.

Yosprala side effects - How does Yosprala make you feel?

Serious Side Effects

  • Change in how much or how often you urinate, lower back or side pain, painful urination, swelling in your hands, ankles, or feet

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Unusual bleeding, bruising, or weakness

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Seizures, tremors, uneven heartbeat, muscle spasms or cramps

  • Blistering, peeling, or red skin rash

  • Bloody, black, or tarry stools, coughing up blood, vomiting of blood or material that looks like coffee grounds

  • Joint pain, rash on your cheeks or arms that gets worse in the sun

  • Severe diarrhea, stomach cramps, fever

  • Pain or swelling in arms or legs without any injury

  • Severe stomach pain, heartburn