What is Yuvafem: Uses, Warnings & Interactions

Follow all the prescriber’s instructions.

Please read the Patient Information sheet that comes with this medicine.

Carefully read and follow the Instructions for Use that come with this medicine.

Put the Yuvafem tablet only in the vagina. Do not take it by mouth.

Use the applicator to insert the tablet. Do not remove the tablet from the applicator.

Administering the insert:

• Wash and dry your hands.

• Remove one applicator from the sheet.

• Tear open the pouch and remove the applicator.

• If the tablet falls out, carefully put it back in the applicator.

• Stand up or lie down to insert the applicator.

• Place the applicator halfway into the vagina or as far as it will comfortably go, whichever is less.

• If the tablet falls out when trying to insert the applicator, throw out the tablet and start with a new applicator.

• Gently press the plunger to release the insert into the vagina.

• The tablet will dissolve in the vagina.

• Gently remove the applicator and throw it away.

Store Yuvafem applicators in their pouches at room temperature. Do not refrigerate.

Ask the prescriber how to manage missed doses.

Take only one dose daily. Do not take two doses on the same day to make up for a missed dose.

Yuvafem should not be used by women who are pregnant or have:

• Unusual vaginal bleeding that has not been checked by a doctor

• A history of blood clots, stroke, or heart attack

• Genetic conditions that increase the risk of blood clots

• Have or have had uterine cancer

• Have or have had certain types of breast cancer

• Liver disease

• Have had an allergic reaction to any ingredient in the formulation

Tell any healthcare provider or other healthcare provider who treats you that you are using this medicine.

Estrogen replacement therapy requires follow-up doctor’s visits and blood tests. Keep all appointments.

Before starting Yuvafem, tell the prescriber if you have:

• Abnormal vaginal bleeding

• A bleeding disorder

• Current or past cancer

• A history of stroke or heart attack

• Current or past blood clot problems

• Heart problems

• Liver problems

• Kidney problems

• Thyroid problems

• Asthma

• Epilepsy

• Diabetes

• Migraine

• Lupus

• Endometriosis

• A hereditary disorder that causes face and throat swelling (hereditary angioedema)

When using Yuvafem, immediately inform the prescriber if you are:

• Pregnant or think you’re pregnant

• Breastfeeding

• Planning to undergo surgery

Estradiol hormone replacement treatment increases the risk of:

• Cancer of the uterine lining (when used alone)

• Breast cancer

• Heart attack

• Stroke

• Blood clots

• Dementia

• Gallbladder disease

Yuvafem can cause serious side effects including:

• High calcium

• Vision changes

• Liver problems

• High blood pressure

• High blood sugar

• Fluid retention

• Fibroid enlargement in the uterus

Yuvafem can worsen certain pre-existing conditions in women including:

• High calcium

• High cholesterol and fats

• Asthma

• Diabetes

• Migraine

• Seizure disorders

• Underactive thyroid

• Endometriosis

• Lupus

• Porphyria 

Immediately stop taking Yuvafem and call a doctor if you experience any vision changes or loss of vision.

Vaginal inserts can cause cuts and other abrasions on the vaginal lining. Talk to the prescriber if this becomes a problem.

To avoid possible drug interactions, tell the prescribing healthcare provider about all the drugs and supplements regularly taken, particularly:

• Other female hormones

• Thyroid hormones

• Carbamazepine, clarithromycin, erythromycin, itraconazole, ketoconazole, phenobarbital, rifampin, ritonavir

Tell other healthcare providers you are using this medicine before they prescribe new medications.

The estradiol in Yuvafem can alter the results of some important blood tests including thyroid, cholesterol, blood sugar, and blood clotting tests.