What is Zelboraf: Uses, Warnings & Interactions

How to take Zelboraf

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Doses should be taken 12 hours apart.

• Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

• If you vomit after you take the medicine, do not take an extra dose. Wait and take your next dose at the normal time.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Missed dose: If it is more than 4 hours before your next dose, take the tablet as soon as you can. If it is less than 4 hours until your next dose, skip the missed dose then take your next dose at the regular time. Do not use extra medicine to make up for a missed dose.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• If you vomit after you take the medicine, do not take an extra dose. Wait and take your next dose at the normal time.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Missed dose: If it is more than 4 hours before your next dose, take the tablet as soon as you can. If it is less than 4 hours until your next dose, skip the missed dose then take your next dose at the regular time. Do not use extra medicine to make up for a missed dose.

• Swallow the tablet whole with a glass of water. Do not crush, break, or chew it.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Doses should be taken 12 hours apart.

What to do if you miss a dose of Zelboraf

Zelboraf contraindications

• This medicine is not right for everyone. Do not use it if you had an allergic reaction to vemurafenib, or if you are pregnant or breastfeeding.

Zelboraf warnings

• Oral routeThis medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective birth control during treatment with this medicine and for 2 weeks after your last dose.

• Do not breastfeed during treatment with this medicine and for 2 weeks after the last dose.

• Tell your doctor if you have liver disease, kidney disease, heart failure, heart rhythm problems, or eye problems. Tell your doctor if you had or are planning to have radiation treatment.

• This medicine may cause the following problems:New skin and non-skin cancer, including melanoma, squamous cell cancer, or myeloid neoplasmSerious skin reactionsChanges in heart rhythm, including QT prolongationLiver problemsEye or vision problemsKidney problemsMuscle, bone, and connective tissue disease, including Dupuytren contracture or plantar fascial fibromatosis

• Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

• This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Zelboraf interactions

• Some medicines can affect how vemurafenib works. Tell your doctor if you are using any of the following:Atazanavir, carbamazepine, clarithromycin, dextromethorphan, digoxin, indinavir, ipilimumab, itraconazole, ketoconazole, midazolam, nefazodone, nelfinavir, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, telithromycin, tizanidine, voriconazoleBlood thinner (including warfarin)

• Tell your doctor if you are breastfeeding, or if you have liver disease, heart failure, or heart rhythm problems. Tell your doctor if you had or are planning to have radiation treatment.

• This medicine may cause the following problems:New melanoma or squamous cell cancerSerious skin reactionsQT prolongation (heart rhythm problem)Liver problemsKidney failure

• Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

• This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. An ECG (electrocardiogram) may be needed to check your heart.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.