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Key takeaways
Breztri Aerosphere is a brand-name, premium-priced COPD maintenance treatment daily inhaler.
Insurance typically covers Breztri Aerosphere prescriptions, but they may impose restrictions.
There is no generic version, so people without insurance will have to pay the full retail price of $934 monthly. There are ways to reduce that price, starting with SingleCare’s prescription drug savings program.
Breztri Aerosphere is a brand-name prescription inhalation aerosol that provides maintenance treatment for chronic obstructive pulmonary disease (COPD). It combines three medications to keep airways open, prevent COPD flare-ups, and minimize hospitalizations. As a brand-name drug, Breztri Aerosphere sells at a premium price. There is no generic version, but there are ways to reduce the price.
Save up to 80% on Breztri with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
Related: Breztri Aerosphere side effects
How much does Breztri Aerosphere cost without insurance?
Uninsured patients can expect to pay about $934 for a single 10.7-gram Breztri Aerosphere inhaler, which contains 120 doses of budesonide (a corticosteroid), glycopyrrolate (an anticholinergic drug), and formoterol (a long-acting beta agonist or LABA)—enough to last 30 days. A year’s worth of treatment at the full retail price will cost approximately $11,000.
If the monthly cost of Breztri Aerosphere is a concern, ask a healthcare professional about other treatment options. Triple therapy, like Breztri Aerosphere, is generally reserved for moderate to severe COPD, so there may only be a limited number of effective options for patients in this category. Besides Breztri Aerosphere, the only other combination triple therapy inhaler available in the U.S. is the brand-name Trelegy Ellipta (umeclidinium-vilanterol-fluticasone furoate). This drug costs even more than Breztri Aerosphere.
Inhalants combining two COPD drugs are also available in brand-name and generic versions, including generic budesonide-formoterol. However, effectiveness may be a concern. For now, the cheapest and most effective alternative to paying the full cash price for Breztri is to purchase it with a SingleCare prescription discount card. The lowest SingleCare discount price for Breztri Aerosphere is $553, a monthly savings of almost $400.
How much does generic Breztri Aerosphere cost without insurance?
Breztri Aerosphere combines three COPD maintenance medications: budesonide, glycopyrrolate, and formoterol. While generic budesonide and formoterol inhalants are available, glycopyrrolate is only found in AstraZeneca’s brand-name inhalants Breztri and Bevespi Aerosphere. Generic Breztri or Bevespi will not be available until May 28, 2030.
For budesonide-formoterol inhalers, the generic versions cost about the same as brand-name Symbicort. A free coupon from SingleCare can dramatically reduce brand-name and generic budesonide-formoterol costs.
| Compare Breztri Aerosphere prices to related drugs | |||
|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Breztri Aerosphere | $934 per 1, 10.7 gm of 160-9-4.8 mcg/act aerosol inhaler | $553 per 1, 10.7 gm of 9-4.8 mcg/act aerosol inhaler of brand-name Breztri Aerosphere | See latest prices |
| Bevespi Aerosphere | $694 per 1, 10.7 gm of 9-4.8 mcg/act aerosol inhaler | $437 per 1, 10.7 gm of 9-4.8 mcg/act aerosol inhaler of brand-name Bevespi Aerosphere | See latest prices |
| Advair HFA | $526 per 1, 12 gm of 115-21 mcg/act aerosol inhaler | $264 per 1, 12 gm of 115-21 mcg/act aerosol inhaler of brand-name Advair HFA | See latest prices |
| Symbicort
(budesonide/formoterol) |
$486 per 1, 10.2 gm of 160-4.5 mcg/act aerosol inhaler | $156 per 1, 10.2 gm of 160-4.5 mcg/act aerosol inhaler | See latest prices |
| Breo Ellipta
(fluticasone-vilanterol) |
$554 per 1, 60 powder breath-activated aerosol inhaler | $246 per 1, 60 powder breath-activated aerosol inhaler of brand-name Breo Ellipta | See latest prices |
| Trelegy Ellipta | $917 per 1, 60 blisters of 100 mcg/62.5 mcg/25 mcg inhaler | $534 per 1, 60 blisters of 100 mcg/62.5 mcg/25 mcg inhaler of brand-name Trelegy | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices at the time of publishing. The listed price without insurance references the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the “Savings options” link to see the latest drug prices.
Breztri Aerosphere costs by dose
Breztri Aerosphere comes in one dosage strength, packaged in two quantities: 28 inhalations (5.9 grams) or 120 inhalations (10.7 grams). The smaller quantity is sample-sized and usually not sold to patients. Patients will always purchase the 30-day, 120-inhalation units for long-term COPD treatment.
Is Breztri Aerosphere covered by insurance?
Most people with health insurance or Medicare Part D are covered without restrictions for Breztri Aerosphere. However, not all insurance plans offer coverage for this drug. The average out-of-pocket cost for people with either health insurance or Medicare Part D drug coverage varies based on the insurance plan’s formulary, copay cost, and coverage gaps. Medicaid coverage varies by state.
How to get Breztri Aerosphere covered by insurance
The most likely reason a Breztri prescription is denied is because the drug is non-formulary. However, two of the drugs contained in the inhaler are usually covered either as single or double medication inhalers, so a generic budesonide-formoterol inhaler will likely be covered. If necessary, the prescribing healthcare provider can submit a formulary exemption request to the insurance company. The process is similar to prior authorization and requires a medical necessity letter from the prescriber.
How to get Breztri Aerosphere without insurance
With an annual price tag reaching $11,000 without insurance coverage, Breztri Aerosphere can be a financial challenge for those without insurance. Patient assistance programs might be an option for some people, but not everyone will be able to meet the eligibility requirements. There are more savings options, starting with SingleCare’s prescription savings program.
1. Use a SingleCare savings card
With SingleCare, people without insurance can save almost $400 on a 30-day supply of Breztri Aerosphere. Those monthly savings will add up to $4,500 or more in a year. Discounts will vary by participating pharmacies. Shop SingleCare discount prices at local pharmacies by visiting SingleCare’s Breztri Aerosphere coupons page. Earn bonus savings on refills and other drugs by signing up for SingleCare’s loyalty savings program.
2. Find the lowest price
Purchasing Breztri Aerosphere at the lowest pharmacy price can reduce the cost of a Breztri Aerosphere inhaler. Browse pharmacy prices on SingleCare to find the lowest price at a pharmacy near you.
3. Ask the prescriber about lower-cost treatment options
Ask your healthcare provider for medical advice about other, less costly COPD medications. There is a trade-off, however. Breztri Aerosphere is usually prescribed to people with more advanced cases of COPD. These alternatives may not be as effective, and the side effects might differ.
- Breztri budesonide, glycopyrrolate, and formoterol fumarate aerosol prescribing information, DailyMed (NIH National Library of Medicine)
- Glycopyrrolate -U.S. patents, Pharmacompass