Key takeaways
Imvexxy is a brand-name prescription drug used to treat painful sex due to menopause.
Imvexxy costs $319 for a 28-day supply without insurance, and there is no lower-priced Imvexxy generic.
Imvexxy may be covered by some insurance plans, but uninsured patients can save with an Imvexxy coupon from SingleCare, switching to other estradiol medications, or price shopping.
Imvexxy is a brand-name prescription estrogen used to treat moderate to severe painful sex (dyspareunia) caused by menopause. Imvexxy vaginal inserts supply estradiol locally to the vaginal lining, improving the health of the vaginal tissues, the elasticity of these tissues, and increasing vaginal lubrication. As a brand-name drug, Imvexxy is more expensive than generic estradiol. Uninsured people who are prescribed Imvexxy, however, have opportunities to save on their prescription or switch to lower-priced alternatives.
RELATED: Estrogen costs & coupons
What is the generic version of Imvexxy?
Imvexxy is a brand-name drug. The Food and Drug Administration (FDA) approved a generic version in late 2025. However, it may take some time for generic versions to be available at pharmacies.
How much does Imvexxy cost without insurance?
Without insurance, the Imvexxy Starter Pack costs about $650 for 18 vaginal inserts ($36 per insert), and each 28-day supply of Imvexxy Maintenance Pack after that costs $319 for 8 vaginal inserts ($40 per insert). At these prices, you can expect to pay about $4,400 or more for the first year of treatment and slightly less than that for each year after without insurance.
While Imvexxy has no exact equivalent, there are other treatment options. Vaginal estradiol can be prescribed in the form of inserts, creams, or rings. Some of these products may be FDA-approved for other conditions, such as vaginal atrophy, vaginal dryness, or vaginal bleeding. Most are brand-name products, but estradiol cream can be purchased as a generic.
If price is an issue, get medical advice from the prescribing healthcare provider about these alternatives.
RELATED: Imvexxy alternatives: What can I take instead of Imvexxy?
Compare Imvexxy prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Imvexxy starter pack (estradiol) | $650 for 1 box of 18 inserts | $428 for 1 box of 18 inserts of brand-name Imvexxy starter pack at Kroger | See latest prices |
| Imvexxy maintenance pack (estradiol) | $319 for 1 box of 8 inserts | $184 for 1 box of 8 inserts of brand-name Imvexxy at Kroger | See latest prices |
| Estrace (estradiol) | $453 for 1, 42.5 gm of 0.1 mg/gm tube of cream | $33 for 1, 42.5 gm of 0.1 mg/gm tube of generic Estrace cream at Walmart | See latest prices |
| Intrarosa (prasterone vaginal) | $423 for 1 box of 28 inserts | $316 for 1 box of 28 inserts of brand-name Intrarosa at Kroger | See latest prices |
| Vagifem (estradiol) | $281 for 1 box of 8 vaginal tablets | $39 for 1 box of 8 vaginal tablets of generic Vagifem at CVS Pharmacy | See latest prices |
Is Imvexxy covered by insurance?
Imvexxy is covered by some health insurance plans, but many Medicare Part D prescription drug plans and Medicaid plans may not cover it. The insurance plans that do cover Imvexxy are likely to cover both the starter and maintenance packs, but they may impose restrictions or require prior authorization before covering them.
Most insurance companies that cover Imvexxy classify the drug in their higher drug tiers, so the out-of-pocket cost may be higher than that of other covered drugs. Women with commercial health insurance coverage for Imvexxy may be eligible to use the Imvexxy Savings Card from TherapeuticsMD to reduce the monthly Imvexxy cost.
How to get Imvexxy without insurance
Paying for a brand-name prescription drug without insurance can be challenging. Still, even without insurance, there are ways to reduce the price of prescription drugs or get similar drugs at a lower cost. For brand-name drugs like Imvexxy, one alternative is to see if the manufacturer offers a savings program or manufacturer coupons. The problem is that these are not always available, and when they are, they have eligibility requirements.
1. Save $1,800 a year on Imvexxy with a SingleCare savings card
You could pay $428 for the Imvexxy Starter Pack ($24 per insert) and $184 for the Imvexxy Maintenance Pack ($23 per insert) with a free Imvexxy coupon from SingleCare, depending on your choice of pharmacy. That could amount to a savings of $1,800 per year. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to sign up.
2. Shop for the lowest price
Different pharmacies charge different prices for the same prescription medications. You may call your local pharmacies to compare prices or use the SingleCare website or app to compare discounts.
3. Ask for a free sample
The prescriber may have free samples of Imvexxy for you to try. Each free sample contains two vaginal inserts, which is enough medicine for one week of maintenance therapy. This isn’t a sustainable savings method for a recurring Imvexxy prescription, but at full retail cost, one week of Imvexxy is worth about $80.
4. Ask about other treatment options
Imvexxy is not the only estrogen that is administered vaginally. Generic estradiol vaginal cream, Estrace vaginal cream, Vagifem vaginal inserts, and the Estring vaginal ring are all estradiol products that can be used instead of Imvexxy. Most can be purchased for less than the price of Imvexxy. Estradiol vaginal cream is the least expensive. With a SingleCare discount card, a 42.5 gm tube of 0.1 mg/gm estradiol vaginal cream can be purchased for around $33, depending on your choice of pharmacy.
There are differences, however, between these drugs and Imvexxy. Start by asking your prescribing healthcare provider about the pros and cons of switching to other estradiol products.
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The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Aug. 6, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Imvexxy estradiol insert prescribing information, DailyMed (NIH National Library of Medicine) (2025)
- Local effects of vaginally administered estrogen therapy: A review, Journal of Pelvic Medicine and Surgery (2009)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
- Evidence-based: Our content is sourced from reputable U.S.-based healthcare professionals and peer-reviewed research.
- Trustworthy: All of SingleCare’s content goes through a multi-phase review process by our writers, editors, and Medical Board in order to provide clear and credible information.