Estrace is a brand-name prescription drug that treats symptoms of menopause such as hot flashes and vaginal dryness. Estrace can also be used to replace low estrogen in the body and prevent osteoporosis in menopausal women. The average Estrace price comes out to $438.17 per 1, 42.5gm of 0.1mg/gm tube of cream. The lowest SingleCare price of Estrace is $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream of generic Estrace. The generic version of Estrace is estradiol, which is usually more affordable than the brand-name version. Using Estrace coupons at SingleCare-participating pharmacies may help you save on your prescription costs for either the generic version or the brand-name version of the medication.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/18/2025
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Estrace is a brand-name prescription drug that treats symptoms of menopause such as hot flashes and vaginal dryness. Estrace can also be used to replace low estrogen in the body and prevent osteoporosis in menopausal women. The average Estrace price comes out to $438.17 per 1, 42.5gm of 0.1mg/gm tube of cream. The lowest SingleCare price of Estrace is $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream of generic Estrace. The generic version of Estrace is estradiol, which is usually more affordable than the brand-name version. Using Estrace coupons at SingleCare-participating pharmacies may help you save on your prescription costs for either the generic version or the brand-name version of the medication.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Estrace Retail Price | Estradiol Retail Price | Estradiol SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $408.85 | $112.20 | $67.92 |
| Walmart | $435.63 | $46.49 | $36.20 |
| Walgreens | $450.08 | $84.07 | $67.58 |
| Kroger Pharmacy | $435.63 | $307.10 | $84.99 |
| Albertsons Pharmacy | - | $122.83 | $42.92 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Estrace is a brand-name prescription drug that treats symptoms of menopause such as hot flashes and vaginal dryness. Estrace can also be used to replace low estrogen in the body and prevent osteoporosis in menopausal women. The average Estrace price comes out to $438.17 per 1, 42.5gm of 0.1mg/gm tube of cream. The lowest SingleCare price of Estrace is $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream of generic Estrace. The generic version of Estrace is estradiol, which is usually more affordable than the brand-name version. Using Estrace coupons at SingleCare-participating pharmacies may help you save on your prescription costs for either the generic version or the brand-name version of the medication.
Without insurance, the retail price of Estrace is estimated to be $438.17 for 1, 42.5gm of 0.1mg/gm tube of cream. SingleCare's coupons may help lower that price to $32.51 for 1, 42.5gm of 0.1mg/gm tube of cream of generic Estrace. Using SingleCare's discount card can also be an affordable way to save up to 80% on the cost of medication.
Depending on your insurance plan, your copay for Estrace can vary. You will have to check with your pharmacist to determine your cost with insurance. SingleCare's Estrace discount card may help reduce the cost of Estrace.
Most Medicare plans will not cover brand-name Estrace. Instead, most Medicare plans will cover the generic version, estradiol. Without Medicare coverage, you'll likely pay full price for Estrace. When you use a SingleCare savings card, your discount could be greater than what you may receive with Medicare. Use the Singlecare search tool to find a participating pharmacy with the lowest available price for your prescription medication.
Estrace is a brand-name drug manufactured by Allergan. Estradiol is the generic version of Estrace. You can use a SingleCare discount card at any participating pharmacy to reduce the cost of brand-name or generic Estrace. CVS Pharmacy, Walmart, Kroger, and Walgreens are some of the participating pharmacies that accept SingleCare coupons for Estrace.
Estrace is a prescription-only female hormone drug that is used to relieve symptoms of menopause. If you’re a woman going through menopause, your body may produce less estrogen. With Estrace, estrogen is replaced to restore normal hormone levels, reducing hot flashes and vaginal dryness. If you have been diagnosed with ovarian failure, your ovaries are no longer producing normal amounts of estrogen. Estrace may be prescribed for ovarian failure to provide the body with adequate levels of estrogen.
Estrace is available as an oral tablet in strengths of 0.5 mg, 1 mg, and 2 mg. Estrace is also available as a 0.01% vaginal cream. Depending on your medical condition, Estrace may be prescribed in varying dosages. Consult with your healthcare provider to determine what dosage is best for you.
The most common side effects of Estrace include headache, breast tenderness, nausea, vomiting, irregular vaginal bleeding, and abdominal pain. Serious side effects of Estrace may include severe headaches, chest pain, changes in vision, shortness of breath, and dizziness. Seek medical attention if you experience serious side effects or side effects that persist or worsen.
Estrogen therapy may increase the risk of endometrial and breast cancer. Talk to your healthcare professional if you have a history of endometrial or breast cancer.
The use of Estrace may increase the risk of blood clots and cardiovascular events such as heart attack and stroke. This risk may be increased in women with a history of blood clots, high blood pressure, high cholesterol, or tobacco use. Consult your healthcare provider if you have a personal or family history of cardiovascular conditions before using estrogen replacement therapy.
Estrace should not be used during known or suspected pregnancy.
This is not a complete list of adverse effects associated with Estrace. Contact your healthcare provider for additional side effects, warnings, and precautions before using Estrace.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved