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Drug overview & main differences | Conditions treated | Efficacy | Insurance coverage and cost comparison | Side effects | Drug interactions | Warnings | FAQ
Irbesartan and valsartan are generic prescription drugs used to treat high blood pressure (hypertension). Both drugs are classified as angiotensin II receptor blockers (ARBs). They work by blocking the effects of angiotensin II, a protein hormone that narrows the blood vessels. Angiotensin II is also involved in the salt and water balance of the body; it increases the retention of salt and water, which can increase blood volume and blood pressure.
Irbesartan and valsartan are part of the same class of drugs. However, they differ in dosages, how long they last in the body, and how they are used. For the most part, these drugs are equally effective for reducing blood pressure. When determining the best drug for you, a healthcare provider will assess different factors, such as cost, overall medical condition, and other drugs being taken.
Continue reading to learn more about the similarities and differences between irbesartan and valsartan.
What are the main differences between irbesartan vs. valsartan
Dosages
Irbesartan is a generic drug available as an oral tablet in strengths of 75 mg, 150 mg, and 300 mg. The typical dose of irbesartan for hypertension is 150 mg to 300 mg per day. The usual dose for diabetic kidney disease (diabetic nephropathy) is 300 mg per day. The brand name of irbesartan is Avapro.
Valsartan is a generic drug available as an oral tablet in strengths of 40 mg, 80 mg, 160 mg, and 320 mg. The typical dose of valsartan for hypertension is 80 mg to 320 mg per day. Valsartan is taken at a lower dose twice daily for heart failure and other cardiovascular problems. The brand name of valsartan is Diovan.
Half-life
Half-life is the time it takes for half the amount of a drug to be cleared from the body. The average half-life of irbesartan is 11 to 15 hours on average, while the average half-life of valsartan is six hours. Therefore, irbesartan lasts longer in the body than valsartan. Although irbesartan stays in the body longer than valsartan, both irbesartan and valsartan are usually taken once daily for high blood pressure.
Age restrictions
Irbesartan is approved to treat hypertension in adults. The use of irbesartan has been studied in children aged 6 to 16 years, but no significant reductions in blood pressure were noted in children using irbesartan. Valsartan, on the other hand, is approved to treat hypertension in children aged 6 to 16 years. Studies have shown that valsartan can significantly reduce systolic and diastolic blood pressure in children.
| Main differences between irbesartan vs. valsartan | ||
|---|---|---|
| Irbesartan | Valsartan | |
| Drug class | Angiotensin II receptor blocker (ARB) | Angiotensin II receptor blocker (ARB) |
| Brand/generic status | Brand and generic version available | Brand and generic version available |
| What is the brand name? | Avapro | Diovan |
| What form(s) does the drug come in? | Oral tablet | Oral tablet |
| What is the standard dosage? | High blood pressure: 150 to 300 mg once daily Diabetic kidney disease: 300 mg once daily |
High blood pressure: 80 to 320 mg once daily High blood pressure (in children aged 6 to 16 years): 1.3-2.7 mg/kg once daily or up to 40 to 160 mg per day Heart failure: 40 to 160 mg twice daily Reduction in risk of death after a heart attack: 20 to 160 mg twice daily |
| How long is the typical treatment? | Long-term | Long-term |
| Who typically uses the medication? | Adults | Adults and children aged 6 years and older |
Conditions treated by irbesartan and valsartan
Irbesartan and valsartan are FDA-approved to treat essential hypertension, or high blood pressure that is not caused by a medical condition. Irbesartan is also approved to treat diabetic nephropathy, or kidney disease linked to Type 1 and Type 2 diabetes. Valsartan may help protect the kidneys and slow the progression of diabetic nephropathy, but this indication would be considered off-label.
Valsartan is approved to treat heart failure in addition to hypertension. Valsartan may help reduce the risk of hospital visits caused by heart failure. In addition to heart failure and hypertension, valsartan can also reduce the risk of death after a heart attack (myocardial infarction) in certain people. Valsartan is approved to reduce the risk of death from a heart attack in people with left ventricular failure or left ventricular dysfunction who are clinically stable.
High blood pressure is linked to cardiovascular disease and events, such as strokes and heart attacks. Controlling blood pressure may help reduce cardiovascular risk.
| Condition | Irbesartan | Valsartan |
| High blood pressure | Yes | Yes |
| Diabetic kidney disease | Yes | Off-label |
| Heart failure | Off-label | Yes |
| Reduction in risk of death after a heart attack | No | Yes |
Is irbesartan or valsartan more effective?
Both irbesartan and valsartan are effective when compared to placebo. However, few studies have directly compared the antihypertensive efficacy of irbesartan and valsartan. The most effective drug will depend on your overall condition and should be discussed with a healthcare provider.
A randomized, open-label study compared the antihypertensive effects of irbesartan and valsartan. No significant differences in the drugs’ effectiveness were found. Researchers concluded that irbesartan and valsartan are equally effective for lowering blood pressure.
A multicenter, randomized clinical trial compared the effects of four different ARBs, including olmesartan, losartan, irbesartan, and valsartan. People who used olmesartan showed greater reductions in blood pressure than those who used one of the other ARBs. However, results found that monotherapy with any of these ARBs can help people with high blood pressure achieve their recommended blood pressure goals.
Discuss antihypertensive options with a healthcare provider. A healthcare provider can measure baseline blood pressure levels, assess how the blood pressure medication is working, and perform routine blood pressure monitoring.
Coverage and cost comparison of irbesartan vs. valsartan
The cost of irbesartan and valsartan is usually around the same price, although the actual price can vary. Both drugs are available as generics, which are often cheaper than brand-name medications.
Irbesartan is a generic drug that most Medicare and insurance plans cover. The average retail price can vary depending on the quantity and dosage prescribed. For a 30-day supply of 300 mg tablets, the average retail price can be around $90. However, using a SingleCare coupon for irbesartan could help lower the price.
Valsartan is also a generic drug that most Medicare and insurance plans cover. Without insurance, the average retail price for 30, 160 mg tablets is around $145. Savings options are available for those without insurance, such as a valsartan SingleCare coupon. In some cases, a prescription discount card can lower the price of a prescription drug more than insurance.
| Irbesartan | Valsartan | |
| Typically covered by insurance? | Yes | Yes |
| Typically covered by Medicare Part D? | Yes | Yes |
| Quantity | 30, 300 mg tablets | 30, 160 mg tablets |
| Typical Medicare copay | $0–$20 | $0–$59 |
| SingleCare cost | $16+ | $12+ |
Common side effects of irbesartan vs. valsartan
Both irbesartan and valsartan have similar tolerability. In other words, they cause similar side effects as ARBs. Common side effects of these drugs include dizziness, fatigue, and diarrhea. Irbesartan can also cause indigestion, while valsartan can cause back or joint pain.
Irbesartan and valsartan can cause low blood pressure associated with changing from a sitting or lying position to a standing position (orthostatic hypotension). High potassium levels (hyperkalemia) can also result from the use of irbesartan or valsartan.
| Irbesartan | Valsartan | |||
| Side Effect | Applicable? | Frequency | Applicable? | Frequency |
| Dizziness | Yes | 10% | Yes | 17% |
| Fatigue | Yes | 4% | Yes | 3% |
| Diarrhea | Yes | 3% | Yes | 5% |
| Indigestion | Yes | 2% | No | – |
| Orthostatic hypotension | Yes | 5% | Yes | 2% |
| High potassium levels | Yes | 2% | Yes | 2% |
| Back pain | No | – | Yes | 3% |
| Joint pain | No | – | Yes | 3% |
Frequency is not based on data from a head-to-head trial. This may not be a complete list of adverse effects that can occur. Please refer to your doctor or healthcare provider to learn more.
Source: DailyMed (Irbesartan), DailyMed (Valsartan)
Drug interactions of irbesartan vs. valsartan
Irbesartan and valsartan can interact with other drugs. Irbesartan and valsartan can increase lithium levels in the blood, which can lead to lithium toxicity. Lithium levels may need to be monitored while taking irbesartan or valsartan.
Taking nonsteroidal anti-inflammatory drugs (NSAIDs) with ARBs can lead to an increased risk of renal, or kidney problems. NSAIDs can also reduce the antihypertensive effects of ARBs.
Aliskiren and angiotensin-converting enzyme inhibitors (ACE inhibitors), such as lisinopril and benazepril, have similar effects as ARBs. It is not recommended to combine these drugs with ARBs, such as irbesartan or valsartan. Taking aliskiren or ACE inhibitors with ARBs increases the risk of hypotension, hyperkalemia, and changes in renal function. It is also not recommended to take more than one ARB at a time for the same reasons.
Drugs and supplements that increase potassium levels in the body can increase the risk of hyperkalemia when taken with an ARB like irbesartan or valsartan. Potassium levels may need to be monitored in people taking an ARB with a potassium-sparing diuretic or potassium supplement.
| Drug | Drug Class | Irbesartan | Valsartan |
| Eskalith (lithium) | Antimanic agents | Yes | Yes |
| Motrin (ibuprofen) Advil (naproxen) Cataflam (diclofenac) |
NSAIDs | Yes | Yes |
| Tekturna (aliskiren) | Direct renin inhibitors | Yes | Yes |
| Lotensin (benazepril) Capoten (captopril) Zestril (lisinopril) Vasotec (enalapril) |
ACE inhibitors | Yes | Yes |
| Avapro (irbesartan) Atacand (candesartan) Micardis (telmisartan) |
ARBs | Yes | Yes |
| Aldactone (spironolactone) Dyrenium (triamterene) Midamor (amiloride) |
Potassium-sparing diuretics | Yes | Yes |
| Potassium chloride Potassium citrate |
Potassium supplements | Yes | Yes |
| Salt substitutes containing potassium | Yes | Yes | |
This may not be a complete list of all possible drug interactions. Consult a healthcare provider with all medications you may be taking.
Warnings of irbesartan and valsartan
Blood pressure and renal function should be monitored in hypertensive patients taking an ARB, such as irbesartan or valsartan. The use of ARBs can increase the risk of low blood pressure levels, which can cause symptoms of dizziness and light-headedness. Irbesartan and valsartan can also cause high potassium levels, especially in people with kidney problems. People at risk of renal failure should be monitored while taking an ARB.
Irbesartan and valsartan, like other ARBs, carry a black box warning that warns against the use of these drugs during pregnancy. Drugs that act on the renin-angiotensin system can lead to the injury or death of an unborn baby. Irbesartan or valsartan should be immediately stopped upon becoming pregnant.
Consult with a healthcare provider for other possible warnings and precautions associated with irbesartan or valsartan.
Frequently asked questions about irbesartan vs. valsartan
What is irbesartan?
Irbesartan is a generic prescription drug used to treat high blood pressure, and it is also FDA-approved to treat diabetic kidney disease. The brand name of irbesartan is Avapro. It is available as an oral tablet in strengths of 75 mg, 150 mg, and 300 mg. Irbesartan is usually taken once per day.
What is valsartan?
Valsartan is a generic prescription drug used to treat high blood pressure. It is also FDA-approved to treat heart failure and reduce the risk of death after a heart attack. Valsartan is known under the brand name Diovan. It is available as an oral tablet in strengths of 40 mg, 80 mg, 160 mg, and 320 mg. Valsartan is taken once or twice daily, depending on the treated condition.
Are irbesartan and valsartan the same?
Irbesartan and valsartan are angiotensin II receptor blockers used for the treatment of hypertension. They both work in identical ways to block the effects of angiotensin II. However, they are different drugs that have different approved uses in addition to treating high blood pressure. Valsartan is also approved for use in children 6 to 16 years old, while irbesartan is only approved in adults.
Is irbesartan or valsartan better?
Both irbesartan and valsartan are effective antihypertensive agents. The best drug will be the one that works for you based on your overall medical condition. Both irbesartan and valsartan are relatively cheap and usually covered by insurance. Consult a healthcare provider to determine the best blood pressure medication for you.
Can I use irbesartan or valsartan while pregnant?
No, irbesartan and valsartan should not be used while pregnant. Taking irbesartan or valsartan while pregnant can lead to the injury or death of an unborn baby.
Can I use irbesartan or valsartan with alcohol?
There are no direct interactions between alcohol and irbesartan or valsartan. However, alcohol may cause changes in blood pressure that can alter the effectiveness of blood pressure medications. Alcohol can also cause drowsiness and dizziness, which are possible side effects of irbesartan and valsartan. Mixing alcohol with these drugs may lead to worsened side effects.
What is a good substitute for irbesartan?
There are several medications that can be used instead of irbesartan. Other antihypertensive drugs include ACE inhibitors, calcium channel blockers, beta-blockers, and diuretics. If blood pressure goals aren’t achieved with irbesartan alone, another medication may be added to therapy with irbesartan. Irbesartan and a diuretic like hydrochlorothiazide are often prescribed together as a combination therapy to lower blood pressure.
Consult with a healthcare provider to determine the best treatment for you. A doctor will consider other cardiovascular risk factors you may have in addition to high blood pressure, such as diabetes and high cholesterol.
Should I stop taking irbesartan?
You should not stop taking irbesartan without first talking with your healthcare provider. Stopping the use of irbesartan may lead to a sudden increase in blood pressure, putting you at risk of other complications like heart attacks or strokes.
What is the safest blood pressure medicine?
Most, if not all, antihypertensive drugs available on the market are effective and safe when taken as directed by a healthcare provider. Common side effects are usually mild and go away on their own. Serious side effects are often associated with taking too much of a drug or taking it with another drug that can increase side effects. The safest blood pressure medicine will also depend on your overall condition. Discuss your options with a healthcare provider.
