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Key takeaways
Nystatin is a prescription antifungal medication used to treat various fungal infections, including oral thrush (candidiasis of the mouth) and skin infections.
Nystatin is available in several dosage forms, including oral treatments (tablets and suspensions) and topical treatments (creams, ointments, and powders).
Most prescription insurance plans, including Medicare, cover both oral and topical nystatin medications.
SingleCare discount cards are a reliable way to lower the price of nystatin.
Nystatin is a generic prescription medication used to treat fungal infections caused by the Candida fungus, including oral thrush (oral candidiasis) and skin infections (also known as yeast infections). This antifungal medicine is available in a variety of dosage formulations, each with its own cost. Oral nystatin can be prescribed as tablets or a suspension, while topical nystatin can be prescribed as a cream, ointment, or powder. All nystatin dosage forms are available as generic medications, but several topical powders still have brand-name drugs (Klayesta, Nyamyc, and Nystop). Without insurance, brand-name Nystop powder costs $180 per 1, 60 gm of 100000 unit/gm bottle, while generic nystatin cream is around $42 for 1, 30 gm of 100000 unit/gm tube of cream. There are a variety of ways to make nystatin prescriptions more affordable.
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How much does nystatin cost without insurance?
The cost of each dosage form of nystatin will vary without insurance. For example, on average, generic nystatin topical cream is about $42 for 1, 30 gm of 100000 unit/gm tube of cream. The brand name Nystop powder costs on average $180 per 1, 60 gm of 100000 unit/gm bottle without insurance. While the duration of treatment varies based on the severity of the infection, most people will need a 7- to 14-day supply of treatment. Several factors can influence the price of a drug. Generally, the average cost of a brand-name form is higher than that of a generic form. Prices also differ between insurance plans, specific drug formularies, and pharmacies. There are other antifungal drugs that you can discuss with your healthcare provider, which may be more affordable options, such as fluconazole or itraconazole for oral infections, and econazole or miconazole for skin infections.
How much does brand-name nystatin cost?
Nystatin dosage forms are available as generic medications, but a few topical powders have brand-name drugs available (Klayesta, Nyamyc, and Nystop). Without insurance, the average retail cash price of the brand Nystop is higher than the generic, averaging $180 per 1, 60 gm of 100000 unit/gm bottle, and the average Nyamyc price is $173 for 1, 60 gm of 100000 unit/gm bottle.
Compare nystatin prices to related drugs |
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|---|---|---|---|
| Drug name | Price without insurance | SingleCare price | Savings options |
| Nystatin
oral suspension (generic) |
$43 per 1, 30 gm of oral suspension (100,000 units/mL) | $14 per 1, 30 gm of oral suspension (100,000 units/mL) of generic nystatin at Walmart | See latest prices |
| Nystatin cream (generic) | $42 per 1, 30 gm of 100000 unit/gm tube of cream | $11 per 1, 30 gm of 100000 unit/gm tube of cream of generic nystatin at Walmart | See latest prices |
| Nystop powder (nystatin) | $180 per 1, 60 gm of 100000 unit/gm bottle | $21 per 1, 60 gm of 100000 unit/gm bottle of generic nystatin at Walmart | See latest prices |
| Nyamyc powder (nystatin) | $173 per 1, 60 gm of 100000 unit/gm bottle | $21 per 1, 60 gm of 100000 unit/gm bottle of generic nystatin at Walmart | See latest prices |
| Fluconazole
oral tablet (generic) |
$35 per 2, 150 mg tablets | $3 per 2, 150 mg tablets of generic fluconazole at Kroger | See latest prices |
| Diflucan
oral suspension (fluconazole) |
$215 per 1, 35 mL of 40 mg/mL bottle | $23 per 1, 35 mL of 40 mg/mL bottle of generic fluconazole at Kroger | See latest prices |
| Itraconazole
oral capsule (generic) |
$1,053 per 60, 100 mg capsules | $50 per 60, 100 mg capsules of generic itraconazole at CVS | See latest prices |
| Clotrimazole cream (generic) | $26 per 1, 45 gm of 1% tube | $16 per 1, 45 gm of 1% tube of generic clotrimazole at Costco | See latest prices |
| Econazole cream (generic) | $230 per 1, 85 gm of 1% tube of cream | $23 per 1, 85 gm of 1% tube of cream of generic econazole at Kroger | See latest prices |
| Ertaczo cream (sertaconazole) | $1,103 per 1, 60 gm of 2% tube | $882 per 1, 60 gm of 2% tube of brand sertaconazole at Kroger | See latest prices |
| Miconazole cream (generic) | $14 per 1, 30 gm of 2% tube of cream | $12 per 1, 30 gm of 2% tube of cream of generic miconazole at Kroger | See latest prices |
Prescription drug prices often change. These are the most accurate medication prices as of November 24, 2025, for the ZIP code 23666. The listed price, without insurance, refers to the price of brand-name drugs (unless otherwise specified). The listed SingleCare price references the price of generic drugs if available. Click the link under “Savings options” to see the latest drug prices.
Is nystatin covered by insurance?
Both oral and topical nystatin forms are typically covered by most insurance plans (commercial and private insurance) as they are available as generics and widely available drugs. However, the specific copay price will vary by plan. UnitedHealthcare (UHC) lists generic oral nystatin, topical nystatin cream, and topical nystatin powder as covered medications in their formulary. Medicare plans cover nystatin drug products and often list them as tier 2. Drug insurance plans typically categorize medications into tiers primarily based on cost (usually consisting of between 3 and 5 tiers), with the higher tiers having a higher cost of the drug.
How to get nystatin without insurance
Paying for expensive brand-name drugs and higher-cost generic alternatives without insurance can be difficult for many people. People could encounter challenges with paying for nystatin prescriptions. Fortunately, there are alternatives to paying full price for a prescription of nystatin without insurance. Patient assistance savings programs and manufacturer coupons may be available, but not everyone meets eligibility requirements for these discounts. Here are some more dependable ways to save money on nystatin:
1. Use a SingleCare discount card
SingleCare discount cards are a free and dependable way to save money, as you can save up to 80% on your prescription drugs. Explore current discount coupons at the SingleCare nystatin coupon page and compare savings at nearby pharmacies.
2. Use prescription insurance
Prescription insurance helps make medications more affordable, and most health insurance plans include prescription coverage. Each insurance provider’s specific drug formulary identifies which drugs are covered and which are not. You can reach out to your specific prescription insurance plan for copay information.
3. Compare pharmacy prices
Comparing drug prices between pharmacies is a useful tactic for finding savings on prescription medications, as savings can vary between pharmacies. SingleCare’s coupon pages can help compare prices at local pharmacies and find the lowest price.
4. Switch to an alternative medication
Alternative medications can often be more affordable options for treatment, offering similar benefits. Consulting with a healthcare professional about alternative medication options can help outline all available options, identify more affordable alternatives, and provide medical guidance on switching to a more suitable medication.
- Cutaneous candidiasis – an evidence-based review of topical and systemic treatments to inform clinical practice, Journal of the European Academy of Dermatology & Venereology (2019)
- Oral candidiasis, StatPearls (2023)
- Nystatin topical powder package insert, FDA.gov
- Nystatin suspension package insert, DailyMed
- Nystop package insert, DailyMed
- Nystatin cream package insert, DailyMed