Key takeaways
Trelegy Ellipta is a brand-name triple-drug inhaler used for maintenance treatment of COPD and asthma.
The cost of Trelegy without insurance is about $963 per month, but it could be $534 with a SingleCare Trelegy Ellipta coupon.
Many insurance plans cover Trelegy Ellipta, but people without insurance can reduce the cost of Trelegy with SingleCare discount coupons.
Trelegy Ellipta (fluticasone/umeclidinium/vilanterol) is a brand-name prescription inhaler that prevents breathing problems and flare-ups in people with chronic obstructive pulmonary disease (COPD) or asthma. As a “triple inhaler,” Trelegy Ellipta contains three classes of medications that help keep airways open if doses are taken daily. Unfortunately, Trelegy Ellipta is a premium-priced, brand-name drug with no lower-priced generic version. Paying the full price of the Trelegy inhaler can be challenging without insurance coverage, but a few suggestions may help reduce the cost.
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How much does Trelegy Ellipta cost without insurance?
If you are paying out of pocket, the Trelegy Ellipta price is $963 for 1, 60 blisters of 100-62.5-25 mcg inhaler. This will purchase a single plastic inhaler with two foil strips, each containing 30 blisters of inhalation powder. Each inhaled dose uses two blisters, one from each foil strip, so the inhaler represents a 30-day supply. When used as a long-term maintenance treatment, Trelegy Ellipta will cost more than $11,000 a year for uninsured patients.
| Compare Trelegy Ellipta prices to related drugs | |||
|---|---|---|---|
| Drug name | Price without insurance of brand-name drug | SingleCare price | Savings options |
| Trelegy Ellipta (fluticasone-umeclidinium-vilanterol) | $963 for 1, 60 blisters of 100-62.5-25 mcg inhaler | $554 for 1, 60 blisters of 100-62.5-25 mcg inhaler of brand-name Trelegy Ellipta at Kroger | See latest prices |
| Breztri Aerosphere (budesonide-glycopyrrolate-formoterol) | $944 for 1, 10.7 gm of 160-9-4.8 mcg/act aerosol inhaler | $572 for 1, 10.7 gm of 160-9-4.8 mcg/act aerosol inhaler of brand-name Breztri Aerosphere at Kroger | See latest prices |
| Breo Ellipta (fluticasone-vilanterol) | $548 for 60 blisters of aerosol breath-activated powder | $274 for 60 blisters of aerosol breath-activated powder of generic Breo Ellipta at CVS Pharmacy | See latest prices |
| Symbicort (budesonide-formoterol) | $484 for 1, 10.2 gm of 160-4.5 mcg/act (120 inhalations) inhaler | $156 for 1, 10.2 gm of 160-4.5 mcg/act (120 inhalations) inhaler of generic Symbicort at CVS Pharmacy | See latest prices |
| Anoro Ellipta (umeclidinium-vilanterol) | $394 for 1, 62.5 mcg/25 mcg inhaler with 60 blisters | $343 for 1, 60 aerosol powder breath-activated blister pack of generic Anoro Ellipta at CVS Pharmacy | See latest prices |
Is Trelegy Ellipta covered by insurance?
Some commercial health insurance plans and Medicare Part D plans cover Trelegy Ellipta. Additionally, many Medicaid plans cover Trelegy, but coverage varies by state. The best way to verify coverage is to look up your drug formulary online or contact your health insurance provider.
RELATED: Does Medicare cover Trelegy Ellipta?
Even if a plan does cover Trelegy, out-of-pocket costs vary depending on the plan’s formulary, copay, and coinsurance. When insurance plans cover Trelegy Ellipta, they typically classify it as a higher-tier drug. According to GSK, the manufacturer of Trelegy, about 82% of Trelegy prescriptions cost less than $50 per month with either commercial health insurance, such as through an employer, or with a Medicare prescription plan.
Insurance companies may require you to try less expensive alternatives to Trelegy Ellipta before approving coverage. This is called step therapy.
To understand your alternatives, it helps to know the active ingredients in Trelegy: fluticasone furoate, umeclidinium, and vilanterol, which are all delivered in a single dose. Fluticasone is an inhaled corticosteroid (ICS) that prevents swelling of the airways. The next two affect the muscles in the airways. Vilanterol is a long-acting beta agonist (LABA) that makes breathing easier by relaxing and dilating the smooth muscle in the airways. Umeclidinium is an anticholinergic or long-acting muscarinic antagonist (LAMA) that prevents those muscles from tightening. Trelegy Ellipta is, then, an ICS-LABA-LAMA inhaler. There’s only one similar triple therapy inhaler on the market: Breztri Aerosphere.
One alternative is to use more than one inhaler to achieve the same goal of using three active ingredients. Using generic versions of dual inhalers, such as Anoro Ellipta, Symbicort, or Breo Ellipta, along with a second generic inhaler containing the third drug in the ICS-LABA-LAMA trio, can save hundreds of dollars and secure insurance approval.
RELATED: Trelegy Ellipta alternatives: What can I take instead of Trelegy Ellipta?
How to get Trelegy Ellipta without insurance
$11,000 a year is a lot to pay for a drug, even for life-saving medicine like Trelegy Ellipta. Thankfully, there are ways to save on Trelegy without insurance.
1. Use a SingleCare discount card
With a SingleCare prescription discount savings card or coupon, the lowest monthly price for Trelegy Ellipta is $554 for 1, 60-blister inhaler at Kroger. That’s almost half the cost of the average retail price. Discounts will vary by participating pharmacies, but most will save $200 or more off the price of Trelegy. SingleCare is free to use and available to everyone. Registered members can save even more, and it’s fast and free to join.
Save up to 80% on Trelegy Ellipta with SingleCare
Different pharmacies offer different prices for the same medication. SingleCare helps find the best price for you.
2. Manufacturer’s coupons and programs
Check the GSK manufacturer’s website for programs that may help decrease the cost of Trelegy Ellipta for those who qualify.
3. Ask the prescriber about alternative maintenance treatments
If Trelegy Ellipta is cost-prohibitive, ask your healthcare provider for additional information and medical advice on Trelegy alternatives.
The SingleCare prices in this article are the most accurate at the time of publishing in ZIP code 23666 as of Aug. 7, 2026. Prices vary by pharmacy. Visit our coupon page for updated drug prices at pharmacies near you.
- Trelegy Ellipta prescribing information, DailyMed (2023)
- GSK pricing information for TRELEGY Ellipta, GlaxoSmithKline (2026)
- Medically accurate: SingleCare’s Medical Review Board analyzes all of our content to confirm it’s in line with current medical advice.
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