What is Apraclonidine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Apraclonidine overview

BRAND NAMES:

  • Iopidine, Iopidine

Generic Names:

  • Apraclonidine Hcl

Uses:

  • Treats or prevents increased pressure in the eye caused by glaucoma or cataract surgery.

Therapeutic Classes:

  • Antiglaucoma

Forms:

  • Liquid, Drop

How it’s taken:

  • Into the eye

What is Apraclonidine used for?

Iopidine is a prescription medicine used along with other medications to treat glaucoma. It comes in the form of ophthalmic drops. It works by reducing the amount of fluid within the eye resulting in a decrease of the amount of pressure inside the eye. It is used on a short term basis to help delay or prevent the need for eye surgery.

What form(s) does Apraclonidine come in

  • Liquid

  • Drop

What are common Apraclonidine doses?

  • Bottle 5ML of 0.5%

  • Bottle 10ML of 0.5%

Common Apraclonidine prescriptions

  • Apraclonidine HCl
    10ml of 0.5% bottle

  • Apraclonidine HCl
    5ml of 0.5% bottle

How to take Apraclonidine

  • You will receive this medicine as an eyedrop 1 hour before and right after your eye surgery.

  • A nurse or other trained health professional will give you this medicine.

  • You will receive this medicine as an eyedrop 1 hour before and right after your eye surgery.

  • A nurse or other trained health professional will give you this medicine.

What to do if you miss a dose of Apraclonidine

Apraclonidine contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to apraclonidine or clonidine.

Apraclonidine warnings

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, high blood pressure, heart or blood vessel disease (including Raynaud disease, thromboangiitis obliterans), or a history of heart attack or stroke.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Lightheadedness or fainting

  • Slow, pounding, or uneven heartbeat

Apraclonidine interactions

  • Do not use this medicine if you are also using an MAO inhibitor (MAOI).

Apraclonidine side effects

Serious Side Effects

  • Slow, pounding, or uneven heartbeat

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blurred vision

  • Dizziness, lightheadedness or fainting

  • Eye redness, burning, itching, or discomfort

  • Fast, pounding, or uneven heartbeat

Less Serious Side Effects

  • Stomach pain, diarrhea, vomiting, sweating of your palms

  • Feeling like there is something in your eye

  • Redness, swelling, or whitening of your eyelids

  • Trouble sleeping, unusual dreams

  • Redness, swelling, or whitening of your eyelids

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