What is Aprodine: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Aprodine overview

BRAND NAMES:

  • Alahist D, Acticon, Acta-Tabs PE, Aprodine, Allergy Relief Nasal Decongestant, Antihistamine & Nasal Decongestant, Allergy Plus Sinus, Allergy Relief-D, Allergy & Congestion Relief, Allegra-D 24HR, Allegra-D 24 Hour Allergy & Congestion, Allegra-D 12 Hour Allergy & Congestion, Allegra-D 12 Hour, Allegra-D, Ala-Hist PE, Aprodine, Nasal Decongestant Antihistamine, Silafed, Silafed, Silafed, Triphed, Trisudrine

Generic Names:

  • Aprodine

Uses:

  • Treats stuffy nose, sneezing, runny nose, and sinus congestion caused by hay fever, colds, or flu., Treats runny nose, nasal congestion, sneezing, and itchy or watery eyes caused by hay fever or the common cold. This medicine is a combination of an antihistamine and a decongestant.

Therapeutic Classes:

  • Antihistamine, Less-Sedating/Decongestant Combination, Antihistamine/Antitussive Combination, Antihistamine/Decongestant Combination, Respiratory Agent, Antihistamine/Decongestant Combination

Forms:

  • Thin Sheet, Capsule, Long Acting Capsule, Tablet, Long Acting Tablet, Chewable Tablet, 24 Hour Tablet, Dissolving Tablet, Liquid, Drop, Liquid, Tablet

How it’s taken:

  • By mouth, By mouth

What is Aprodine used for?

What form(s) does Aprodine come in

  • Thin Sheet

  • Capsule

  • Long Acting Capsule

  • Tablet

  • Long Acting Tablet

  • Chewable Tablet

  • 24 Hour Tablet

  • Dissolving Tablet

  • Liquid

  • Drop

  • Liquid

  • Tablet

What are common Aprodine doses?

  • Bottle 100 Tablets

  • Box 24 Tablets

Common Aprodine prescriptions

  • Aprodine
    100 tablets bottle

  • Aprodine
    24 tablets box

How to take Aprodine

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

  • Completely chew the chewable tablet before swallowing it. Swallow the regular tablet, regular capsule, extended-release tablet, or extended-release capsule whole. Do not crush, break, or chew it.

  • If you use a powder, stir the medicine into water and drink it right away. Do not keep any unused mixture to take later.

  • If you are using the Softchew®, you may let it melt in your mouth, or you may chew it. If you are using the dissolving tablet, let the tablet melt in your mouth.

  • Measure the oral liquid medicine with a marked measuring spoon, medicine cup, oral syringe, or medicine dropper.

  • You might need to shake the oral liquid well just before you use it. Follow the directions on the label or ask your pharmacist.

  • Measure the oral liquid medicine with a marked measuring spoon, medicine cup, oral syringe, or medicine dropper.

  • Completely chew the chewable tablet before swallowing it. Swallow the regular tablet, regular capsule, extended-release tablet, or extended-release capsule whole. Do not crush, break, or chew it.

  • If you use a powder, stir the medicine into water and drink it right away. Do not keep any unused mixture to take later.

  • You might need to shake the oral liquid well just before you use it. Follow the directions on the label or ask your pharmacist.

  • If you are using the Softchew®, you may let it melt in your mouth, or you may chew it. If you are using the dissolving tablet, let the tablet melt in your mouth.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Follow the instructions on the medicine label if you are using this medicine without a prescription.

What to do if you miss a dose of Aprodine

  • If you miss a dose or forget to take your medicine, take it as soon as you can. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose.

  • Do not use extra medicine to make up for a missed dose.

  • Keep all medicine away from children and never share your medicine with anyone.

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Oral routeAsk your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Aprodine contraindications

  • You should not use this medicine if you have had an allergic reaction to pseudoephedrine or triprolidine. You should not use this medicine if you have used an MAO inhibitor (MAOI) such as Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

  • You should not use this medicine if you have had an allergic reaction to any antihistamine or decongestant, or if you have used an MAO inhibitor (such as Nardil®, Marplan®, or Parnate®) within the past 14 days. Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years old. Using these medicines in very young children might cause serious or possibly life-threatening side effects.

Aprodine warnings

  • Do not give this medicine to a child under 6 years of age unless your doctor tells you to.

  • If your symptoms do not improve within 7 days or if they get worse, call your doctor.

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Make sure your doctor knows if you are pregnant or breastfeeding.

  • Tell your doctor if you have diabetes, thyroid problems, high blood pressure, glaucoma, an enlarged prostate, or a history of heart disease.

  • Some brands of this medicine may contain alcohol. Read the label carefully or ask your pharmacist so you know what is in your product.

  • Children may be more sensitive to this medicine than adults, especially if they take too much. Always read the medicine label closely so you give your child the right amount. Ask your pharmacist or doctor if you are not sure how much medicine to give your child.

  • Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, high blood pressure, diabetes, liver disease, glaucoma, asthma, emphysema, seizure disorder, a disorder of the urinary tract, or an overactive thyroid.

  • If your symptoms do not improve within 7 days or if they get worse, call your doctor. If you have a severe sore throat, fever, or thick yellow or green mucus, call your doctor.

  • Some brands of this medicine may contain phenylalanine (aspartame). If you have a health problem called phenylketonuria, ask your doctor before using this medicine.

  • This medicine can make you drowsy or restless. Avoid taking at bedtime if it makes you restless. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

Aprodine interactions

  • Avoid drinking alcohol or using any other medicines that make you sleepy. These include sleeping pills, other cold and allergy medicine, narcotic pain relievers, and sedatives.

  • If your symptoms do not improve within 7 days or if they get worse, call your doctor. If you have a severe sore throat, fever, or thick yellow or green mucus, call your doctor.

  • Some brands of this medicine may contain phenylalanine (aspartame). If you have a health problem called phenylketonuria, ask your doctor before using this medicine.

  • This medicine can make you drowsy or restless. Avoid taking at bedtime if it makes you restless. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Some brands of this medicine may contain alcohol. Read the label carefully or ask your pharmacist so you know what is in your product.

  • Children may be more sensitive to this medicine than adults, especially if they take too much. Always read the medicine label closely so you give your child the right amount. Ask your pharmacist or doctor if you are not sure how much medicine to give your child.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not drink alcohol while you are using this medicine.

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Do not give this medicine to a child under 6 years of age unless your doctor tells you to.

  • If your symptoms do not improve within 7 days or if they get worse, call your doctor.

Aprodine side effects

Serious Side Effects

  • Trouble breathing

  • Fast, pounding, or irregular heartbeat

  • Severe headache

  • Skin rash, hives, or itching

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Fast, pounding, or uneven heartbeat.

  • Loss of appetite.

Less Serious Side Effects

  • Trouble sleeping.

  • Feelings of restlessness or excitement (especially in children).

  • Loss of appetite.

  • Dry mouth, nose, or throat

  • Trouble urinating

  • Nausea

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