Azulfidine Coupons & Prices

Sulfasalazine

Azulfidine (sulfasalazine) is an FDA-approved, brand-name, anti-inflammatory drug used to reduce the swelling of ulcerative colitis, a disease in which the inner lining of the colon becomes inflamed and develops ulcers and sores. Azulfidine also reduces swelling of the joints in patients with rheumatoid arthritis. Azulfidine is only available with a prescription. The retail price of Azulfidine is $231.99 per 120, 500mg tablets, but a SingleCare Azulfidine coupon brings this cost down to our lowest price of $19.88 per 120, 500mg tablets of generic Azulfidine. Thousands of pharmacies accept SingleCare prescription discount cards that can save you up to 80% on all your prescription medications.

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Azulfidine coupon at Publix Pharmacy
$22.88
$ 19.88
$3 off with signupwith signup

Show this free card to your pharmacist.

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Azulfidine coupon at Walmart Neighborhood Market Pharmacy
$28.46
$ 25.46
$3 off with signupwith signup

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Azulfidine coupon at Walmart Pharmacy
$28.46
$ 25.46
$3 off with signupwith signup
Azulfidine coupon at Kroger Pharmacy
$28.81
$ 25.81
$3 off with signupwith signup
Azulfidine coupon at Harris Teeter Pharmacy
$28.81
$ 25.81
$3 off with signupwith signup
Azulfidine coupon at Food Lion Pharmacy
$ 32.60
$ 32.99
$45.00
$ 42.00
$3 off with signupwith signup
$53.10
$ 50.10
$3 off with signupwith signup

About SingleCare Pricing

SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.

Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.

Prices updated: 12/05/2025

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About Azulfidine

Azulfidine (sulfasalazine) is an FDA-approved, brand-name, anti-inflammatory drug used to reduce the swelling of ulcerative colitis, a disease in which the inner lining of the colon becomes inflamed and develops ulcers and sores. Azulfidine also reduces swelling of the joints in patients with rheumatoid arthritis. Azulfidine is only available with a prescription. The retail price of Azulfidine is $231.99 per 120, 500mg tablets, but a SingleCare Azulfidine coupon brings this cost down to our lowest price of $19.88 per 120, 500mg tablets of generic Azulfidine. Thousands of pharmacies accept SingleCare prescription discount cards that can save you up to 80% on all your prescription medications.

Azulfidine Price History & Information

Price History for Azulfidine (Brand) & Sulfasalazine (Generic)

120 count, tablet, 500mg

Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.

Average 1-Month Prices for Azulfidine (Brand) & Sulfasalazine (Generic)

120 count, tablet, 500mg
PharmacySulfasalazine Retail PriceSulfasalazine SingleCare Price
CVS Pharmacy$48.00$31.20
Walmart$39.60$25.20
Walgreens$56.40$16.80
Kroger Pharmacy$32.40$28.80

These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.

About Azulfidine

Azulfidine (sulfasalazine) is an FDA-approved, brand-name, anti-inflammatory drug used to reduce the swelling of ulcerative colitis, a disease in which the inner lining of the colon becomes inflamed and develops ulcers and sores. Azulfidine also reduces swelling of the joints in patients with rheumatoid arthritis. Azulfidine is only available with a prescription. The retail price of Azulfidine is $231.99 per 120, 500mg tablets, but a SingleCare Azulfidine coupon brings this cost down to our lowest price of $19.88 per 120, 500mg tablets of generic Azulfidine. Thousands of pharmacies accept SingleCare prescription discount cards that can save you up to 80% on all your prescription medications.

Azulfidine FAQs

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

How much does Azulfidine cost without insurance?

The cash price for Azulfidine is $231.99 for 120, 500mg tablets. With a SingleCare Azulfidine coupon, a prescription for generic Azulfidine costs $19.88 per 120, 500mg tablets. For all your prescription needs, a SingleCare prescription savings card can save you as much as 80% on your purchases.

How much does Azulfidine cost with insurance?

Your copay for Azulfidine with insurance will vary depending on your insurance plan. Ask your pharmacist to compare your insurance copay to SingleCare. You may find your SingleCare discount card saves you money with SingleCare, generic Azulfidine costs $19.88 for 120, 500mg tablets.

Does Medicare cover Azulfidine and how much does it cost?

Brand-name Azulfidine will not be covered for Medicare-eligible patients under Medicare Part D and Medicare Advantage plans. However, Medicare prescription drug plans do cover prescriptions for the generic version of the drug, sulfasalazine. Still, your copay cost will vary according to your plan, so check with your pharmacist. You could save money with a SingleCare Azulfidine coupon—the price of generic Azulfidine with a SingleCare savings card is $19.88 per 120, 500mg tablets.

Is there a generic of Azulfidine?

Azulfidine is a brand-name prescription drug. At the present time, several different pharmaceutical companies manufacture generic sulfasalazine in both instant-release and extended-release forms. Before you pay for your Azulfidine prescription, find free coupons for the generic or brand-name Azulfidine on our website or app.

What is Azulfidine?

Azulfidine is a brand-name prescription drug that reduces the inflammation (swelling) of ulcerative colitis and rheumatoid arthritis.

Ulcerative colitis is an autoimmune disease in which the immune system mistakenly targets tissues in the colon as if they were an infection. The immune system response causes swelling and tissue damage (sores) along the inner lining of the colon and rectum. The active ingredient in Azulfidine, sulfasalazine, works by reducing this swelling and so reduces the symptoms–fever, diarrhea, bleeding, and pain–caused by the disease.

With rheumatoid arthritis, the immune system targets the lining of the joints, causing swelling, pain, and tissue damage. As with ulcerative colitis, sulfasalazine reduces swelling by preventing the production of a hormone that stimulates an inflammatory response.

Extended-release Azulfidine, also called Azulfidine EN-tabs, is also sometimes used, along with rest and other drugs, for rheumatoid arthritis when other prescription drugs have failed.

Azulfidine is taken in immediate-release or extended-release doses in tablet form. Before taking this medicine, tell your doctor about all of the allergies and medical conditions you have. You should not take Azulfidine if you are allergic to sulfa drugs or NSAIDs like aspirin or if you have certain medical conditions such as intestinal or urinary blockage or porphyria. Tell your doctor about all of the medicines you take, including Rx and OTC drugs, vitamins, and supplements. This ensures your doctor can prescribe Azulfidine safely with your existing medical conditions and medications.

What are the side effects of Azulfidine?

Although not a complete list, common side effects of Azulfidine include loss of appetite, headache, indigestion, stomach pain, nausea, vomiting, dizziness, and lowered sperm count. Mood changes are less common and include insomnia and depression. Azulfidine may cause an orange/yellow discoloration of the skin and urine.

Allergic reactions to Azulfidine are rare but can be life-threatening or fatal. Symptoms may include rashes, hives, fever, shortness of breath, difficulty breathing, and swelling around the face. Seek emergency medical attention if you have signs of an allergic reaction. Skin reactions may occur—get emergency medical help right away if you have burning eyes, skin pain, or a red or purple rash with blistering or peeling skin.  Report side effects to your doctor. Before taking Azulfidine, read the Medication Guide, which has important information and warnings. 

Consult your doctor or healthcare professional for any additional information and medical advice before taking Azulfidine.

Medically reviewed by Karen BergerPharm.D.
Licensed Pharmacist

After receiving her doctorate from the University of Pittsburgh School of Pharmacy, Karen Berger, Pharm.D., has worked in both chain and independent community pharmacies. She currently works at an independent pharmacy in New Jersey. Dr. Berger enjoys helping patients understand medical conditions and medications—both in person as a pharmacist, and online as a medical writer and reviewer.

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Where are Azulfidine coupons from SingleCare accepted?

SingleCare is accepted at most national pharmacies and grocers, including the following:

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