Skyrizi is a prescription medication used to treat plaque psoriasis, psoriatic arthritis, and Crohn’s disease. It works by targeting specific proteins in the body involved in inflammation. Skyrizi is a brand-name drug containing the active ingredient risankizumab-rzaa, a monoclonal antibody. The average retail price of Skyrizi is $13,305.47 for 1, 10ml of 600mg/10ml vial. However, with a SingleCare Skyrizi coupon, you could reduce this cost, potentially to as low as $9,833.91 for 1, 10ml of 600mg/10ml vial at participating pharmacies.
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Prices updated: 12/18/2025
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Skyrizi is a prescription medication used to treat plaque psoriasis, psoriatic arthritis, and Crohn’s disease. It works by targeting specific proteins in the body involved in inflammation. Skyrizi is a brand-name drug containing the active ingredient risankizumab-rzaa, a monoclonal antibody. The average retail price of Skyrizi is $13,305.47 for 1, 10ml of 600mg/10ml vial. However, with a SingleCare Skyrizi coupon, you could reduce this cost, potentially to as low as $9,833.91 for 1, 10ml of 600mg/10ml vial at participating pharmacies.
Skyrizi is a prescription medication used to treat plaque psoriasis, psoriatic arthritis, and Crohn’s disease. It works by targeting specific proteins in the body involved in inflammation. Skyrizi is a brand-name drug containing the active ingredient risankizumab-rzaa, a monoclonal antibody. The average retail price of Skyrizi is $13,305.47 for 1, 10ml of 600mg/10ml vial. However, with a SingleCare Skyrizi coupon, you could reduce this cost, potentially to as low as $9,833.91 for 1, 10ml of 600mg/10ml vial at participating pharmacies.
The cost of Skyrizi is generally higher than other drugs, at an average retail price of around $13,305.47 for 1, 10ml of 600mg/10ml vial. Retail prices can vary based on different factors like pharmacy location and prescribed quantity. With a SingleCare coupon, you might find Skyrizi at a lower price, potentially around $9,833.91 for 1, 10ml of 600mg/10ml vial.
The cost of Skyrizi with insurance depends on your plan's coverage, prescribed quantity, and other factors. Insurance may help cover a portion of the cost, but copays or coinsurance may still apply. It's recommended to check with your insurance provider and compare it with SingleCare's discounted price for the best deal.
Medicare coverage for Skyrizi varies based on the plan, prescription details, and coverage stage. Contact your Medicare insurance plan’s provider for more information on the cost of Skyrizi. For those without Medicare, a SingleCare Skyrizi coupon may be a potential savings option. A SingleCare Skyrizi coupon may help lower the price to $9,833.91 for 1, 10ml of 600mg/10ml vial at participating pharmacies.
Skyrizi is currently available as a brand-name drug only. There is no generic version available at this time.
Skyrizi is a prescription drug that helps treat severe cases of plaque psoriasis, psoriatic arthritis, and Crohn’s disease, which are conditions linked to an overactive immune response. The active ingredient in Skyrizi, risankizumab-rzaa, works by targeting interleukin-23 (IL-23), a key protein involved in inflammation in the immune system. As a result, Skyrizi can help alleviate symptoms of certain inflammatory conditions.
Skyrizi is available as a subcutaneous (under the skin) or intravenous (into the vein) injection. The subcutaneous injections come as a single-dose prefilled pen, syringe, or cartridge in strengths of 75 mg/0.83 mL to 360 mg/2.4 mL. The intravenous injection comes as a 600 mg/10 mL single-dose vial. The dosage of Skyrizi depends on the condition being treated. However, it’s typically given periodically every eight or 12 weeks. Always consult a healthcare provider for appropriate dosage instructions.
Skyrizi may cause side effects. The most common side effects of Skyrizi include:
Injection site reactions
Upper respiratory infections
Headache
Joint pain
Stomach pain
Low red blood cells (anemia)
Back pain
Fever
Fatigue
Urinary tract infections
Skyrizi is not typically associated with hair loss or weight changes. However, it may carry a risk of serious side effects, such as severe allergic reactions, liver problems, and an increased risk of infections. Seek immediate medical attention if you experience signs or symptoms of an allergic reaction, such as hives, swelling of the face or throat, or trouble breathing. Consult a healthcare provider for other potential side effects, drug interactions, and warnings.
Skyrizi has been associated with potential liver problems, although such cases are relatively rare and generally linked to the starting phases of treatment. Healthcare providers may recommend regular liver blood tests when using Skyrizi, especially for those with a history of liver issues. Any symptoms of liver problems, such as yellowing of the skin or eyes, should be reported to a healthcare provider immediately.
Determining whether Skyrizi or Humira is better depends on the person’s medical condition, history, and response to treatment. Both medications are used to treat conditions like psoriatic arthritis and plaque psoriasis, but they work in slightly different ways. Skyrizi targets interleukin-23 (IL-23), while Humira targets tumor necrosis factor (TNF). Consult a healthcare provider to determine the most appropriate treatment option.
The onset of action for Skyrizi can vary from person to person. Some people may start seeing improvements in their symptoms within four weeks of starting treatment, while for others, it may take over four months. In any case, the full benefits of Skyrizi might not be seen until several months into treatment. Regular visits with a healthcare provider are recommended to monitor the effectiveness of the treatment and make adjustments as needed.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved