Bupropion extended-release (sustained release) is a commonly-prescribed atypical antidepressant—an FDA-approved drug that treats depression but works differently than other antidepressants. On average, Bupropion SR costs $98.06 per 60, 150mg tablets without insurance. With SingleCare, Bupropion SR can cost as little as $6.20 for 60, 150mg tablets.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Bupropion extended-release (sustained release) is a commonly-prescribed atypical antidepressant—an FDA-approved drug that treats depression but works differently than other antidepressants. On average, Bupropion SR costs $98.06 per 60, 150mg tablets without insurance. With SingleCare, Bupropion SR can cost as little as $6.20 for 60, 150mg tablets.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Wellbutrin Sr Retail Price | Bupropion Hcl Er (Sr) Retail Price | Bupropion Hcl Er (Sr) SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | $559.20 | $93.00 | $44.60 |
| Walmart | - | $30.90 | $23.40 |
| Walgreens | $595.80 | $15.28 | $12.41 |
| Kroger Pharmacy | $596.40 | $91.50 | $7.97 |
| Albertsons Pharmacy | - | $85.20 | $15.36 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Bupropion extended-release (sustained release) is a commonly-prescribed atypical antidepressant—an FDA-approved drug that treats depression but works differently than other antidepressants. On average, Bupropion SR costs $98.06 per 60, 150mg tablets without insurance. With SingleCare, Bupropion SR can cost as little as $6.20 for 60, 150mg tablets.
The generic of Bupropion SR costs $6.20 for 60, 150mg tablets with a free Bupropion SR coupon from SingleCare. However, you could pay less depending on your Rx details. Use the dropdown menu above to enter your prescription information (i.e., brand/generic, form, dosage, quantity) to get the most accurate prices of Bupropion SR with SingleCare at your local pharmacies.
A 30-day supply of Bupropion SR costs $98.06 for 60, 150mg tablets without insurance coverage. By using a SingleCare prescription discount coupon for Bupropion SR, you could pay as little as $6.20 for 60, 150mg tablets of Bupropion SR.
Health insurance usually covers Bupropion SR without restrictions to treat depression. Although usually placed in the lowest copay tiers, the insurance plan may have additional out-of-pocket fees, such as deductibles or co-insurance. Ask the pharmacist to compare the price of Bupropion SR with the SingleCare Bupropion SR price. It may be cheaper to forego insurance and buy Bupropion SR with SingleCare.
Medicare Part D and most Medicare Advantage drug plans cover Bupropion SR. If the out-of-pocket expense is higher than expected, use a SingleCare Bupropion SR coupon without insurance. With SingleCare’s savings program, Bupropion SR can cost as little as $6.20 for 60, 150mg tablets.
Most people on Medicaid are covered for Bupropion SR, but formularies vary between states. If coverage is denied, use a SingleCare Bupropion SR coupon to lower the cash price of Bupropion SR to as low as $6.20 for 60, 150mg tablets.
The brand-name version of Bupropion SR is Wellbutrin SR. It’s a premium-priced drug, so people with a prescription for Wellbutrin could switch to generic Bupropion SR or use a prescription drug discount coupon from SingleCare.
Bupropion SR is a middle-priced generic drug that may be challenging to pay for month after month. The surest way to save money on Bupropion SR is to use a SingleCare savings card at a participating pharmacy. SingleCare’s lowest price for Bupropion SR is $6.20 for 60, 150mg tablets. SingleCare members who join SingleCare’s bonus loyalty program can earn additional savings on future prescription drug purchases every time they use SingleCare’s discount program.
Prescription savings can also be found by comparing prescription prices among pharmacies to find the lowest Bupropion SR price.
Other ways of saving include enrolling in Medicaid or Medicare Part D Extra Help. Community resources are also available, including 340B clinics or hospitals that could sell Bupropion SR at a government-subsidized price.
Other atypical antidepressants that are cheaper than Bupropion SR are trazodone and mirtazapine. Both are commonly used for depression, but will vary in effectiveness and common side effects.
The lowest-priced antidepressants are tricyclic antidepressants, such as amitriptyline. They are among the most affordable prescription drugs available. However, they aren’t used as much as other antidepressants because of problems with effectiveness and side effects.
SSRIs (selective serotonin reuptake inhibitors) are the first-line treatment for major depressive disorder. If they haven’t been tried, both fluoxetine and paroxetine have lower retail prices than Bupropion SR.
Over-the-counter drugs or supplements that can help mood cannot be substituted for prescription drugs that treat depression or similar mental health problems.
All these drugs can be purchased at low prices using SingleCare drug coupons. However, everyone’s situation is different. Ask a healthcare professional for medical advice before switching to a lower-priced antidepressant.
SingleCare coupons are accepted at most major pharmacies and grocers, i.e., Walgreens, Kroger, Walmart, CVS, Safeway, and more. You can text, email, print, or save your free Bupropion SR coupon to your digital wallet and show a pharmacist when you pick up your prescription.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved