What is Chlorzoxazone: Uses, Warnings & Interactions
Chlorzoxazone is a generic muscle relaxant that relieves pain due to temporary musculoskeletal conditions. It slows down nerves in the spinal cord and brain to reduce muscle spasms. Chlorzoxazone tablets are taken three to four times daily, but the dosage can be reduced as the pain fades. Drowsiness, dizziness, and impairment are the most common side effects of this medicine, so people taking it for pain relief should be careful about driving and other potentially hazardous activities.
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Chlorzoxazone overview
BRAND NAMES:
No brand name versions
Generic Names:
Chlorzoxazone
Uses:
Chlorzoxazone relieves pain and discomfort due to acute muscle problems
Therapeutic Classes:
Centrally acting muscle relaxant
Forms:
Tablet
How it’s taken:
By mouth
What is Chlorzoxazone used for?
Along with rest and physical therapy, chlorzoxazone relieves pain and improves the range of movement in people with acute and painful musculoskeletal conditions.
What form(s) does Chlorzoxazone come in
Tablet
250 mg
375 mg
500 mg
750 mg
What are common Chlorzoxazone doses?
As adjunctive therapy along with rest and physical therapy to relieve pain associated with acute musculoskeletal conditions: 250–750 mg taken three to four times daily
Common Chlorzoxazone prescriptions
Chlorzoxazone
375mg tabletChlorzoxazone
500mg tabletChlorzoxazone
750mg tablet
How to take Chlorzoxazone
Your doctor will tell you how much medicine to use. Do not use more than directed.
Doses are taken every six to eight hours.
Chlorzoxazone tablets can be taken with or without food.
To avoid stomach upset, take this medicine with food or milk.
Swallow the tablet with a drink of water.
People who are unable to swallow tablets can crush them and mix them with food, juice, or milk.
Chlorzoxazone 750 mg tablets are scored so they can be divided into 250 mg (1/3 tablet) and 500 mg (2/3 tablet) doses. If you don’t know how to break a scored tablet, have a pharmacist demonstrate the best procedure.
Store chlorzoxazone tablets in a closed container at room temperature.
What to do if you miss a dose of Chlorzoxazone
Ask the prescriber how to manage a missed dose.
Never take an extra dose to make up for a missed dose.
Chlorzoxazone contraindications
This medicine is not right for everyone.
This medicine should never be taken by anyone who has had an allergic reaction to chlorzoxazone.
Chlorzoxazone warnings
Tell any doctor or other healthcare provider who treats you that you are using this medicine.
Chlorzoxazone can damage the liver. Your doctor will need to perform regular blood tests to catch possible liver injury and other side effects. Keep all appointments.
Before taking chlorzoxazone, tell the prescriber if you are pregnant, breastfeeding, or have liver problems.
Chlorzoxazone can make you drowsy, dizzy, and impaired. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
Keep this medicine securely out of the reach of children.
Chlorzoxazone interactions
To avoid potentially hazardous drug interactions, tell the prescriber about all prescription drugs, over-the-counter medications, and supplements you use before taking chlorzoxazone tablets.
Tell other doctors you are using this medicine before they prescribe new medications.
Taking chlorzoxazone with other drugs that slow down the nervous system (CNS depressants) could worsen the sedative side effects of chlorzoxazone. Tell the doctor about your use of any drug that makes you sleepy, particularly:
Opioids
Sedatives (benzodiazepines)
Other muscle relaxants
Sleeping pills
Allergy medicine
Do not drink alcohol while you are using this medicine.
Do not use cannabis products while on chlorzoxazone.
Chlorzoxazone side effects
Serious side effects
Talk to a doctor if you notice any signs or symptoms of a possible serious side effect, including:
Dark urine, fever, rash, fatigue, nausea, vomiting, loss of appetite, upper abdominal pain, yellow skin or eyes
Blood in the stools, dark and tarry stools, blood or blood clots in the vomit
Allergic reaction: Hives, skin redness, itchiness, rash, small red dots on the skin, skin discoloration, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
Less serious side effects
Drowsiness
Dizziness
Feeling bad
Sources:
Chlorzoxazone tablet prescribing information, DailyMed (NIH National Library of Medicine)
Lorzone drug summary, Prescribers’ Digital Reference (PDR)
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