Desvenlafaxine Succinate ER is an extended-release generic drug used to treat moderate to severe depression. Desvenlafaxine Succinate ER works by increasing certain chemicals that help transmit signals between nerve cells. This, in turn, strengthens brain circuits that help to regulate mood. On average, the retail price of Desvenlafaxine Succinate ER is $272.77 for 30, 50mg tablets, but only costs $129.99 for 30, 50mg tablets of generic Desvenlafaxine Succinate ER with a SingleCare Desvenlafaxine Succinate ER coupon. Many local pharmacies—CVS, Target, Longs Drugs, Walgreens, and Duane Reade—accept SingleCare.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Desvenlafaxine Succinate ER is an extended-release generic drug used to treat moderate to severe depression. Desvenlafaxine Succinate ER works by increasing certain chemicals that help transmit signals between nerve cells. This, in turn, strengthens brain circuits that help to regulate mood. On average, the retail price of Desvenlafaxine Succinate ER is $272.77 for 30, 50mg tablets, but only costs $129.99 for 30, 50mg tablets of generic Desvenlafaxine Succinate ER with a SingleCare Desvenlafaxine Succinate ER coupon. Many local pharmacies—CVS, Target, Longs Drugs, Walgreens, and Duane Reade—accept SingleCare.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Desvenlafaxine Er Retail Price | Desvenlafaxine Er SingleCare Price |
|---|---|---|
| CVS Pharmacy | $183.00 | $167.70 |
| Walmart | $183.10 | $143.70 |
| Walgreens | $185.10 | $156.30 |
| Kroger Pharmacy | $174.00 | $147.00 |
| Albertsons Pharmacy | $173.70 | $166.20 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Desvenlafaxine Succinate ER is an extended-release generic drug used to treat moderate to severe depression. Desvenlafaxine Succinate ER works by increasing certain chemicals that help transmit signals between nerve cells. This, in turn, strengthens brain circuits that help to regulate mood. On average, the retail price of Desvenlafaxine Succinate ER is $272.77 for 30, 50mg tablets, but only costs $129.99 for 30, 50mg tablets of generic Desvenlafaxine Succinate ER with a SingleCare Desvenlafaxine Succinate ER coupon. Many local pharmacies—CVS, Target, Longs Drugs, Walgreens, and Duane Reade—accept SingleCare.
A prescription will cost around $272.77 for 30, 50mg tablets for uninsured customers, but dosages may vary. With a SingleCare Desvenlafaxine Succinate ER coupon, you will pay only $129.99 for 30, 50mg tablets of generic Desvenlafaxine Succinate ER for the same prescription of Desvenlafaxine Succinate ER.
Your copay for Desvenlafaxine Succinate ER with insurance will vary depending on your plan and the dosage required. Ask your pharmacist to compare your insurance copay to SingleCare. You may find your SingleCare discount card saves you money—with SingleCare, Desvenlafaxine Succinate ER only costs $129.99 for 30, 50mg tablets of generic Desvenlafaxine Succinate ER.
Desvenlafaxine Succinate ER is usually not covered for Medicare-eligible patients under Medicare Part D and Medicare Advantage. Medicare-eligible patients can save money with SingleCare Desvenlafaxine Succinate ER coupons—the price of Desvenlafaxine Succinate ER with a SingleCare discount card is only $129.99 for 30, 50mg tablets of generic Desvenlafaxine Succinate ER.
Desvenlafaxine Succinate ER is a generic extended-release prescription drug and is the active ingredient in the brand-name prescription drug Khedezla. Several pharmaceutical companies manufacture generic Desvenlafaxine Succinate ER, including Alembic, West Ward, and Mylan. Before you pay for your Desvenlafaxine Succinate ER prescription, find free coupons for the generic or brand-name Desvenlafaxine Succinate ER on our website or app.
Desvenlafaxine Succinate ER is a generic extended-release prescription drug used to treat moderate to severe depression. Desvenlafaxine Succinate ER strengthens brain circuits that help to regulate mood.
Desvenlafaxine Succinate ER belongs to a class of drugs called SSRIs (selective serotonin reuptake inhibitors). These drugs work by preventing chemicals important to nerve cell communication from being reabsorbed back into nerve cells. SSRIs, you might say, keep the communication channels between nerve cells open for a longer period of time. This strengthens circuits in the brain that are vital to regulating mood.
Although not a complete list, common side effects of Desvenlafaxine Succinate ER include nausea, diarrhea, constipation, drowsiness, dizziness, dry mouth, weight loss, headache, decreased sex drive, delayed orgasm, chills, tremors, and loss of appetite. Mental and mood changes include insomnia, strange dreams, irritability, feeling jittery, and anxiety. Allergic reactions to Desvenlafaxine Succinate ER are rare but include rashes, hives, and swelling.
Desvenlafaxine Succinate ER increases the amount of serotonin in the body. Too much serotonin (serotonin syndrome) can cause moderate to severe side effects, such as fever, agitation, overactive reflexes, dilated pupils, and sweating.
The most serious side effects are liver problems, mania, glaucoma, high blood pressure, and, most seriously, suicidal thoughts for patients under the age of 24.
Desvenlafaxine Succinate ER is not an addictive drug, but may have withdrawal symptoms when discontinued abruptly.
SingleCare is accepted at most national pharmacies and grocers, including the following:
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved