Desvenlafaxine ER is a generic prescription drug used to treat major depressive disorder. The average retail price of Desvenlafaxine ER is around $337.21 for 30, 100mg tablet extended release 24 hours. Pay $18.25 for 30, 100mg tablet extended release 24 hours of generic Desvenlafaxine ER by using a SingleCare Desvenlafaxine ER coupon. This coupon can be redeemed for immediate savings at participating local pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Desvenlafaxine ER is a generic prescription drug used to treat major depressive disorder. The average retail price of Desvenlafaxine ER is around $337.21 for 30, 100mg tablet extended release 24 hours. Pay $18.25 for 30, 100mg tablet extended release 24 hours of generic Desvenlafaxine ER by using a SingleCare Desvenlafaxine ER coupon. This coupon can be redeemed for immediate savings at participating local pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Pristiq Retail Price | Desvenlafaxine Succinate Er Retail Price | Desvenlafaxine Succinate Er SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | - | $209.10 | $51.60 |
| Walmart | $520.20 | $144.00 | $22.60 |
| Walgreens | $567.90 | $222.60 | $120.24 |
| Kroger Pharmacy | - | $341.87 | $18.60 |
| Albertsons Pharmacy | - | $318.64 | $46.54 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Desvenlafaxine ER is a generic prescription drug used to treat major depressive disorder. The average retail price of Desvenlafaxine ER is around $337.21 for 30, 100mg tablet extended release 24 hours. Pay $18.25 for 30, 100mg tablet extended release 24 hours of generic Desvenlafaxine ER by using a SingleCare Desvenlafaxine ER coupon. This coupon can be redeemed for immediate savings at participating local pharmacies.
Usually the cost of Desvenlafaxine ER without insurance coverage is around $337.21 for 30, 100mg tablet extended release 24 hours. SingleCare can help you to save on this total with a Desvenlafaxine ER coupon. Pay as little as $18.25 for 30, 100mg tablet extended release 24 hours of generic Desvenlafaxine ER when you use SingleCare’s Desvenlafaxine ER coupon at participating drugstores.
The cost of Desvenlafaxine ER with insurance may vary based on the type of insurance coverage plan that you are enrolled in. Contact your insurance provider directly to find out exactly how much Desvenlafaxine ER costs under your current insurance plan. SingleCare can help you easily save on your Desvenlafaxine ER purchases. Pay $18.25 for 30, 100mg tablet extended release 24 hours of generic Desvenlafaxine ER when you use SingleCare’s Desvenlafaxine ER coupon card.
Desvenlafaxine ER is usually covered by Medicare Part D and Medicare Advantage plans. The average copay for Desvenlafaxine ER with Medicare varies. Spend $18.25 instead of $337.21 for 30, 100mg tablet extended release 24 hours of Desvenlafaxine ER when you use your SingleCare savings card at participating local pharmacies. Talk to your local pharmacist today to find out more about saving with SingleCare.
Desvenlafaxine ER is usually covered by Medicaid, but coverage may vary by state and Medicaid plan. Depending on the state, Medicaid copays typically range from $0 to $3. Contact your Medicaid plan to see if Desvenlafaxine ER is covered.
You can pay as little as $18.25 for 30, 100mg tablet extended release 24 hours of Desvenlafaxine ER with a SingleCare coupon. If you sign up for SingleCare’s loyalty program, you can save even more.
If you still have difficulty affording Desvenlafaxine ER, other ways can help you save. These include:
Applying for Medicaid, depending on eligibility requirements
Enrolling in commercial insurance
Asking your healthcare provider for free samples
Enrolling in patient assistance programs, depending on availability and eligibility
Checking for manufacturer coupons
Enrolling in Medicare if you are 65 years or older
Shopping around to see the cost of Desvenlafaxine ER at different pharmacies
Desvenlafaxine ER is a generic prescription medication. The brand-name version of this drug is Pristiq.
The cost of Desvenlafaxine ER may vary based on the pharmacy and insurance plans. Other antidepressants may be a more affordable alternative. These include serotonin and norepinephrine reuptake inhibitors (SNRIs), such as venlafaxine and duloxetine, and selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine and sertraline. Talk to your healthcare provider to see which medication works best for you.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved