Pristiq is a brand-name antidepressant that's used to treat major depressive disorder. It works by increasing serotonin and norepinephrine levels in the brain. Serotonin and norepinephrine are chemicals that may be unbalanced in people with depression. Pristiq comes in the form of an extended-release oral tablet. The price of Pristiq is typically around $543.31 for 30, 100mg tablet extended release 24 hours of Pristiq. Try Pristiq coupons from SingleCare to get a free discount on your next Pristiq refill. You could pay as little as $18.25 for 30, 100mg tablet extended release 24 hours of generic Pristiq with SingleCare's free coupons for Pristiq.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/20/2025
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Pristiq is a brand-name antidepressant that's used to treat major depressive disorder. It works by increasing serotonin and norepinephrine levels in the brain. Serotonin and norepinephrine are chemicals that may be unbalanced in people with depression. Pristiq comes in the form of an extended-release oral tablet. The price of Pristiq is typically around $543.31 for 30, 100mg tablet extended release 24 hours of Pristiq. Try Pristiq coupons from SingleCare to get a free discount on your next Pristiq refill. You could pay as little as $18.25 for 30, 100mg tablet extended release 24 hours of generic Pristiq with SingleCare's free coupons for Pristiq.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Pristiq Retail Price | Desvenlafaxine Succinate Er Retail Price | Desvenlafaxine Succinate Er SingleCare Price |
|---|---|---|---|
| CVS Pharmacy | - | $209.10 | $51.60 |
| Walmart | $520.20 | $144.00 | $22.53 |
| Walgreens | $567.90 | $222.60 | $120.04 |
| Kroger Pharmacy | - | $342.03 | $18.60 |
| Albertsons Pharmacy | - | $318.64 | $46.54 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Pristiq is a brand-name antidepressant that's used to treat major depressive disorder. It works by increasing serotonin and norepinephrine levels in the brain. Serotonin and norepinephrine are chemicals that may be unbalanced in people with depression. Pristiq comes in the form of an extended-release oral tablet. The price of Pristiq is typically around $543.31 for 30, 100mg tablet extended release 24 hours of Pristiq. Try Pristiq coupons from SingleCare to get a free discount on your next Pristiq refill. You could pay as little as $18.25 for 30, 100mg tablet extended release 24 hours of generic Pristiq with SingleCare's free coupons for Pristiq.
The average retail price of Pristiq without insurance coverage is around $543.31 for 30, 100mg tablet extended release 24 hours of Pristiq. SingleCare prescription discount cards can help you get maximum savings prescription drug costs. Use a Pristiq coupon from SingleCare and pay the lowest cash price of $18.25 for 30, 100mg tablet extended release 24 hours of generic Pristiq on your next Pristiq refill.
Digital and printable coupons are available on the SingleCare website and app. Your pharmacist can save the unique coupon ID in the pharmacy's system for future refills. SingleCare coupons are accepted at major pharmacies including but not limited to CVS Pharmacy, Walmart, Kroger, Walgreens, and more.
The price of Pristiq is mostly determined by the type of insurance plan you have and the plan’s drug formulary. Ask a local pharmacist to assist you with finding out how much your Pristiq prescription costs. Using a SingleCare savings card may help bring your Pristiq prescription cost down to about $18.25 for 30, 100mg tablet extended release 24 hours of generic Pristiq, depending on the pharmacy you go to. Compare the cost of Pristiq with your insurance versus the cost with a SingleCare coupon in order to find the most affordable price for you.
Pristiq is not usually covered by Medicare, but the generic version of Pristiq usually is. Copays could still cost $168 or more with Medicare. You can use SingleCare to lower your out-of-pocket costs for your Pristiq prescription. Search the SingleCare website or app for brand-name Pristiq or generic desvenlafaxine to start saving.
Desvenlafaxine is the generic version of Pristiq. Both the generic and the brand-name drug are approved by the FDA to treat major depressive disorder.
Pristiq is a prescription medication used to treat major depressive disorder. It belongs to a group of drugs known as serotonin and norepinephrine reuptake inhibitors (SNRIs). This medication works by increasing the levels of certain chemicals in the brain that may be unbalanced in people who suffer from depression. Regular use of Pristiq may help improve mood, energy levels, and overall feelings of well-being.
Pristiq comes in the form of an oral tablet and can be used with or without food. Check with your healthcare professional for dosage instructions before using this drug. Pristiq should not be crushed, chewed, or dissolved in water, as these actions could release all of the drug at once and increase the risk of side effects.
Be sure to tell your doctor about any medications that you may currently be taking and any allergies you may have before starting Pristiq. You should not use Pristiq if you are allergic to venlafaxine or desvenlafaxine. Some medications such as serotonergic drugs may interact with Pristiq and cause a serious condition known as serotonin syndrome. Inform your doctor if you also take stimulants, herbals, or opioids, as these drugs may interact with Pristiq and increase the risk of adverse effects.
Dizziness, constipation, drowsiness, insomnia, and nausea are some possible side effects of Pristiq. This is not a complete list, so other side effects not listed here may also occur. Check with your doctor for medical advice if any of these side effects persist or worsen. Your doctor may recommend monitoring for side effects after starting treatment.
Although rare, this medication may cause an excessive increase in serotonin levels, which can lead to a serious condition called serotonin syndrome. The risk of serotonin syndrome is higher if you're already taking medications that increase your serotonin levels, such as SSRIs or other antidepressants. It is important to tell your doctor about all medications you are currently using before starting treatment with Pristiq.
Consult your healthcare provider about other medical conditions or possible warnings and precautions to be aware of before taking Pristiq.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved