Lomotil (diphenoxylate and atropine) is a prescription drug used to treat diarrhea. Diphenoxylate is an opioid that slows the contractions of muscles in the intestines. Atropine is added to prevent drug abuse and overdose as it can cause unpleasant side effects in high doses. It is recommended to take Lomotil along with appropriate fluid and electrolyte treatment. The retail price of Lomotil is $129.95 for 30, 2.5-0.025mg tablets. However, you may be able to use SingleCare's Lomotil coupon to save money and pay only $14.11 for 30, 2.5-0.025mg tablets of generic Lomotil. Free discount card cards from SingleCare are accepted at participating pharmacies. Continue to the FAQ section to learn about Lomotil, how much it costs, how it works, and the side effects that may occur.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Lomotil (diphenoxylate and atropine) is a prescription drug used to treat diarrhea. Diphenoxylate is an opioid that slows the contractions of muscles in the intestines. Atropine is added to prevent drug abuse and overdose as it can cause unpleasant side effects in high doses. It is recommended to take Lomotil along with appropriate fluid and electrolyte treatment. The retail price of Lomotil is $129.95 for 30, 2.5-0.025mg tablets. However, you may be able to use SingleCare's Lomotil coupon to save money and pay only $14.11 for 30, 2.5-0.025mg tablets of generic Lomotil. Free discount card cards from SingleCare are accepted at participating pharmacies. Continue to the FAQ section to learn about Lomotil, how much it costs, how it works, and the side effects that may occur.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Diphenoxylate-Atropine Retail Price | Diphenoxylate-Atropine SingleCare Price |
|---|---|---|
| CVS Pharmacy | $43.28 | $30.00 |
| Walmart | $30.00 | $13.50 |
| Walgreens | $12.00 | $12.00 |
| Kroger Pharmacy | $31.50 | $10.31 |
| Albertsons Pharmacy | $22.80 | $10.20 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Lomotil (diphenoxylate and atropine) is a prescription drug used to treat diarrhea. Diphenoxylate is an opioid that slows the contractions of muscles in the intestines. Atropine is added to prevent drug abuse and overdose as it can cause unpleasant side effects in high doses. It is recommended to take Lomotil along with appropriate fluid and electrolyte treatment. The retail price of Lomotil is $129.95 for 30, 2.5-0.025mg tablets. However, you may be able to use SingleCare's Lomotil coupon to save money and pay only $14.11 for 30, 2.5-0.025mg tablets of generic Lomotil. Free discount card cards from SingleCare are accepted at participating pharmacies. Continue to the FAQ section to learn about Lomotil, how much it costs, how it works, and the side effects that may occur.
Cash-paying customers can expect to pay $129.95 for 30, 2.5-0.025mg tablets for a standard supply of Lomotil. With a SingleCare Lomotil coupon, you could pay a reduced cost of $14.11 for 30, 2.5-0.025mg tablets of generic Lomotil. SingleCare prescription savings cards may help you save up to 80% the cash price of your prescription medications.
Lomotil copays vary by insurance plan. With SingleCare, a prescription supply for Lomotil could cost $14.11 for 30, 2.5-0.025mg tablets of generic Lomotil, which may be lower than your insurance copay. Before you overpay for Lomotil, ask your local pharmacist to compare your insurance copay to the potential savings with a SingleCare prescription discount card.
Lomotil may be covered by Medicare Advantage and Medicare Part D prescription drug plans. The copay for Lomotil with Medicare will vary depending on your plan. Talk to your insurance provider for more information on the costs of Lomotil with your plan. If you are uninsured or don’t have adequate coverage with Medicare, a SingleCare Lomotil coupon can provide prescription savings at major pharmacies, such as Target, Longs Drugs, Walmart, and many others.
Lomotil is a brand-name prescription drug. Generic Lomotil, or combined diphenoxylate and atropine, is available. A generic version of Lomotil is manufactured by Mylan, Mayne Pharma, and Leading Pharma, among other manufacturers.
Lomotil (diphenoxylate and atropine) is a combination prescription drug used along with appropriate fluid and electrolyte therapy to treat severe diarrhea. Diarrhea is characterized by frequent bowel movements and loose, watery stools. Severe diarrhea can cause life-threatening dehydration.
The active ingredient in Lomotil, diphenoxylate, is an opioid that slows down movement in the intestines and reduces the frequency and intensity of intestinal muscle contractions. As a result, waste moves through the intestines more slowly so the body has more time to absorb water and nutrients.
Diphenoxylate is an opioid that has the potential to be abused when taken alone. As a result, Lomotil contains a small amount of an anti-abuse agent called atropine, which produces unpleasant side effects when too much Lomotil is taken.
Lomotil tablets contain 2.5 mg of diphenoxylate and 0.025 mg of atropine sulfate. The usual recommended dose is two tablets taken four times per day. Improvement in diarrhea symptoms should occur within 48 hours after starting treatment. If you don’t experience improvement in symptoms within 10 days, consult a doctor for further guidance.
Lomotil should not be used in people with diarrhea caused by certain bacterial infections. Lomotil should be used with caution in people with liver or kidney disease. Consult a doctor before taking Lomotil if you have other medical conditions or you are taking other medications.
Lomotil may cause different side effects, which may be related to the dosage of the medication. Side effects of diphenoxylate include drowsiness, dizziness, restlessness, headache, nausea, vomiting, and abdominal pain. This medication may also cause other side effects like depression, euphoria, confusion, itching, and swelling of the gums.
Lomotil contains atropine to deter abuse of the drug. It can cause unpleasant side effects when too much of the medication is taken. The atropine component of Lomotil may cause side effects, such as flushing, dry mouth, dry eyes, blurred vision, fast heartbeat, urinary retention, and hyperthermia.
An overdose on Lomotil can be life-threatening. Severe side effects associated with an overdose of Lomotil include slowed breathing (respiratory depression), delirium, lethargy, seizures, flushing, and coma.
The use of Lomotil may increase the risk of dehydration and an electrolyte imbalance. It is recommended to drink plenty of fluids with electrolytes while taking Lomotil.
This is not a complete list of side effects. Consult your doctor or healthcare professional for additional information and medical advice regarding other possible side effects or drug interactions. You can report negative side effects to the FDA.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved