What is Drizalma Sprinkle: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Drizalma Sprinkle overview

BRAND NAMES:

  • Cymbalta, Drizalma Sprinkle, Irenka

Generic Names:

  • Drizalma Sprinkle

Uses:

  • Treats depression, anxiety, diabetic peripheral neuropathy, fibromyalgia, and chronic muscle or bone pain. This medicine is an SSNRI.

Therapeutic Classes:

  • Antianxiety, Antidepressant, Central Nervous System Agent, Neuropathic Pain Agent

Forms:

  • Capsule, Delayed Release Capsule

How it’s taken:

  • By mouth

What is Drizalma Sprinkle used for?

What form(s) does Drizalma Sprinkle come in

  • Capsule

  • Delayed Release Capsule

What are common Drizalma Sprinkle doses?

  • Capsule Delayed Release Sprinkle 20MG

  • Capsule Delayed Release Sprinkle 30MG

  • Capsule Delayed Release Sprinkle 40MG

  • Capsule Delayed Release Sprinkle 60MG

How to take Drizalma Sprinkle

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • Delayed-release capsule: Swallow the capsule whole. Do not crush, chew, break, or open it. Do not open the Cymbalta® delayed-release capsule and sprinkle the contents on food or in liquids.

  • If you have trouble swallowing the Drizalma Sprinkle„¢ delayed release capsule: You may open the capsule and sprinkle the contents over one tablespoon (15 mL) of applesauce. Swallow the mixture right away and do not save any of the mixture to use later.You may open the capsule and pour the contents to an all plastic catheter tip syringe and add 50 mL of water. Do not use other liquids. Gently shake it for 10 seconds, and then use it through a nasogastric tube. Rinse with additional water (about 15 mL) if needed.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

  • If you have trouble swallowing the Drizalma Sprinkle„¢ delayed release capsule: You may open the capsule and sprinkle the contents over one tablespoon (15 mL) of applesauce. Swallow the mixture right away and do not save any of the mixture to use later.You may open the capsule and pour the contents to an all plastic catheter tip syringe and add 50 mL of water. Do not use other liquids. Gently shake it for 10 seconds, and then use it through a nasogastric tube. Rinse with additional water (about 15 mL) if needed.

  • Delayed-release capsule: Swallow the capsule whole. Do not crush, chew, break, or open it. Do not open the Cymbalta® delayed-release capsule and sprinkle the contents on food or in liquids.

  • Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

What to do if you miss a dose of Drizalma Sprinkle

Drizalma Sprinkle contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to duloxetine.

Drizalma Sprinkle warnings

  • Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping

  • Unusual bleeding or bruising

  • Lightheadedness, dizziness, or fainting

  • Restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there

  • This medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel depressed and have thoughts about hurting yourself.

  • This medicine can cause changes in your blood pressure. This may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Stand up slowly to avoid falls.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause the following problems: Serious liver problemsSerotonin syndrome (more likely when used with certain other medicines)Increased risk of bleeding problemsSerious skin reactionsLow sodium levels in the blood

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, diabetes, digestion problems, glaucoma, heart disease, high or low blood pressure, or problems with urination. Tell your doctor if you smoke or you have a history of seizures, or drug or alcohol addiction.

Drizalma Sprinkle interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Do not drink alcohol while you are using this medicine.

  • Some medicines can affect how duloxetine works. Tell your doctor if you are using any of the following:Buspirone, cimetidine, ciprofloxacin, enoxacin, fentanyl, lithium, St John's wort, theophylline, tramadol, tryptophan, or warfarinAmphetaminesBlood pressure medicineDiuretic (water pill)Medicine for heart rhythm problems (including flecainide, propafenone, quinidine)Medicine to treat migraine headaches (including triptans)NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)Other medicine to treat depression or mood disorders (including amitriptyline, desipramine, fluoxetine, imipramine, nortriptyline, paroxetine)Phenothiazine medicine (including thioridazine)

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not take duloxetine if you have used an MAO inhibitor (MAOI) within the past 14 days. Do not start taking an MAO inhibitor within 5 days of stopping duloxetine.

Drizalma Sprinkle side effects

Serious Side Effects

  • Lightheadedness, dizziness, fainting

  • Decrease in how much or how often you urinate

  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes

  • Unusual bleeding or bruising

  • Feeling more energetic than usual

  • Confusion, weakness, muscle twitching

  • Eye pain, vision changes, seeing halos around lights

  • Anxiety, restlessness, fever, fast heartbeat, sweating, muscle spasms, diarrhea, seeing or hearing things that are not there

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Blistering, peeling, red skin rash

  • Unusual moods or behaviors, worsening depression, thoughts about hurting yourself, trouble sleeping

Less Serious Side Effects

  • Unusual drowsiness, sleepiness, or tiredness

  • Headache

  • Dry mouth, constipation, mild nausea

  • Decrease in appetite or weight

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