What is Endocet: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Endocet overview

BRAND NAMES:

  • Endocet, Nalocet, Percocet, Primlev, Prolate, Dvorah, Endocet, Lorcet, Lorcet HD, Lorcet Plus, Lortab 10/325, Lortab 5/325, Lortab 7.5/325, Lortab Elixir, Nalocet, Norco, Percocet, Primlev, Prolate, Trezix

Generic Names:

  • Oxycodone-Acetaminophen

Uses:

  • Relieves pain., Treats moderate to moderately severe pain. This medicine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic, Opioid/Acetaminophen Combination, Analgesic, Opioid/Acetaminophen Combination

Forms:

  • Liquid, Tablet, Capsule, Long Acting Tablet, Tablet, Liquid, Capsule

How it’s taken:

  • By mouth, By mouth

What is Endocet used for?

Oxycodone-Acetaminophen comes in capsule form and is used as a pain reliever. Oxycodone is an opioid pain medication and acetaminophen is a less potent pain reliever that increases the effects of oxycodone. Oxycodone-Acetaminophen works by changing the way the brain and nervous system respond to pain. Common side effects of Oxycodone-Acetaminophen include dizziness, drowsiness and feelings of extreme happiness or sadness.

What form(s) does Endocet come in

  • Liquid

  • Tablet

  • Capsule

  • Long Acting Tablet

  • Tablet

  • Liquid

  • Capsule

What are common Endocet doses?

  • Tablet 10-325MG

  • Tablet 5-325MG

  • Tablet 7.5-325MG

  • Tablet 2.5-325MG

Common Endocet prescriptions

  • Endocet
    100 tablets bottle

  • Endocet
    20 tablets bottle

  • Endocet
    60 tablets bottle

  • Endocet
    10-325mg tablet

  • Endocet
    2.5-325mg tablet

  • Endocet
    5-325mg tablet

  • Endocet
    7.5-325mg tablet

How to take Endocet

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. Do not lick or wet the tablet before placing it in your mouth. Do not give this medicine through a feeding tube.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

  • Missed dose: If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • Oral liquid: Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. Do not lick or wet the tablet before placing it in your mouth. Do not give this medicine through a feeding tube.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.

  • Drink plenty of liquids to help avoid constipation.

  • Your doctor will tell you how much medicine to use. Do not use more than directed.

  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.

  • Drink plenty of liquids to help avoid constipation.

What to do if you miss a dose of Endocet

  • Some of these medicines need to be used on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor pharmacist for instructions. Do not use extra medicine to make up for a missed dose.

  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Endocet contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to acetaminophen or oxycodone, or if you have serious lung or breathing problems (including asthma, respiratory depression), or stomach or bowel blockage (including paralytic ileus).

  • You should not use this medicine if you have had an allergic reaction to acetaminophen, codeine, hydrocodone, propoxyphene, or sulfites. You should not use this medicine if you have had an allergic reaction to any other opioid pain medicine.

Endocet warnings

  • Make sure your doctor knows if you are pregnant or breast feeding, or if you have a head injury, or other conditions that may cause an increase in intercranial pressure (pressure inside your head). Make sure your doctor knows if you have severe kidney problems or severe liver problems, or if you have hypothyroidism (lack of thyroid function). Make sure your doctor knows if you have Addison's disease (adrenal gland disease), or if you have enlarged prostate or urethral stricture. Make sure your doctor knows if you have any abdominal problems, or if you have lung disease or asthma.

  • This medicine may make you dizzy or drowsy. Avoid driving, using machines, or anything else that could be dangerous if you are not alert.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • When a mother is breastfeeding and takes codeine, there is a very small chance that this medicine could cause serious side effects in the baby. This is because codeine works differently in a few women, so their breast milk contains too much medicine. If you take codeine, be alert for these signs of overdose in your nursing baby: sleeping more than usual, trouble breastfeeding, trouble breathing, or being limp and weak. Call the baby's doctor right away if you think there is a problem. If you cannot talk to the doctor, take the baby to the emergency room or call 911.

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Sleep-related breathing problems (including sleep apnea, sleep-related hypoxemia)Liver problemsSerious skin reactionsSerotonin syndrome (when used with certain medicines)

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, low blood pressure, breathing problems or lung disease (including COPD), thyroid problems, Addison disease, pancreas or gallbladder problems, prostate problems, trouble urinating, or a stomach problems, or a history of head injury or brain damage, seizures, or alcohol or drug abuse. Tell your doctor if you are allergic to codeine.

Endocet interactions

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • This medicine contains acetaminophen. Read the labels of all other medicines you are using to see if they also contain acetaminophen, or ask your doctor or pharmacist. Do not use more than 4 grams (4,000 milligrams) total of acetaminophen in one day.

  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver, and your risk is higher if you also drink alcohol.

  • This medicine may make you dizzy or drowsy. Do not drive or do anything that could be dangerous until you know how this medicine affects you.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are using buprenorphine, butorphanol, nalbuphine, pentazocine, a benzodiazepine, or a muscle relaxer (including cyclobenzaprine, metaxalone).

  • Do not drink alcohol while you are using this medicine. Acetaminophen can damage your liver, and alcohol can increase this risk. Do not take acetaminophen without asking your doctor if you have 3 or more drinks of alcohol every day.

  • Some medicines can affect how this medicine works. Tell your doctor if you are using any of the following: Carbamazepine, erythromycin, ketoconazole, lamotrigine, mirtazapine, naltrexone, phenytoin, probenecid, propranolol, rifampin, ritonavir, tramadol, trazodone, or zidovudineBirth control pillsDiuretic (water pill)Medicine to treat depressionPhenothiazine medicineTriptan medicine to treat migraine headaches

  • Do not use Xartemis„¢ XR if you are using or have used an MAO inhibitor in the past 14 days.

  • Make sure your doctor knows if you are using a monoamine oxidase inhibitor (MAOI) medicine, such as Eldepryl®, Marplan®, Nardil®, or Parnate®. Make sure your doctor knows if you are also using a medicine to treat depression, such as amitriptyline, doxepin, nortriptyline, Elavil®, Pamelor®, or Sinequan®. Make sure your doctor knows if you are taking an anticholinergic medicine, such as atropine, methscopolamine, or scopolamine.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol.

  • Do not drink alcohol while you are using this medicine.

  • Tell any doctor or dentist who treats you that you are using this medicine. This medicine may affect certain medical test results.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • When a mother is breastfeeding and takes codeine, there is a very small chance that this medicine could cause serious side effects in the baby. This is because codeine works differently in a few women, so their breast milk contains too much medicine. If you take codeine, be alert for these signs of overdose in your nursing baby: sleeping more than usual, trouble breastfeeding, trouble breathing, or being limp and weak. Call the baby's doctor right away if you think there is a problem. If you cannot talk to the doctor, take the baby to the emergency room or call 911.

Endocet side effects

Serious Side Effects

  • Severe constipation, nausea, or vomiting

  • Dark urine or pale stools, loss of appetite, stomach pain, yellow skin or eyes

  • Blue lips, fingernails, or skin

  • Anxiety, restlessness, fast heartbeat, fever, muscle spasms, twitching, diarrhea, seeing or hearing things that are not there

  • Blistering, peeling, red skin rash

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Extreme weakness, shallow breathing, uneven heartbeat, seizures, sweating, or cold or clammy skin

  • Trouble breathing or slow breathing

  • Severe confusion, lightheadedness, dizziness, or fainting

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Dizziness.

  • Seeing or hearing things that are not there.

  • Very slow heartbeat.

  • Skin rash.

  • Vision changes.

Less Serious Side Effects

  • Feeling unusually anxious, excited, fearful, or tired.

  • Change in how much or how often you urinate.

  • Nausea, vomiting, constipation, stomach pain or upset, or heartburn.

  • Cold, clammy skin.

  • Skin rash.

  • Vision changes.

  • Mild sleepiness or drowsiness

  • Mild constipation, nausea, or vomiting

  • Mild nausea or vomiting

  • Headache

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