What is Hylenex? Uses, warnings & side effects

Updated May 14, 2025  •  Published Dec 30, 2020

Hylenex overview

BRAND NAMES:

  • Amphadase, Hylenex, Vitrase, Vitrase

Generic Names:

  • Hylenex

Uses:

  • Helps your body absorb other medicines. Also helps add fluid to your body when you are dehydrated.

Therapeutic Classes:

  • Tissue Permeability Modifier

Forms:

  • Injectable

How it’s taken:

  • By injection

What is Hylenex used for?

What form(s) does Hylenex come in?

  • Injectable

What are common Hylenex dosages?

  • Vial 1ML of 150UNIT/ML

Hylenex images - What does Hylenex look like?

  • Hylenex
    1ml of 150unit/ml vial

How to take Hylenex

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Before your injection, you may be given a skin test to make sure you are not allergic to this medicine.

  • Injection routeYour doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.

  • Injection routeA nurse or other health provider will give you this medicine.

  • Before your injection, you may be given a skin test to make sure you are not allergic to this medicine.

What to do if you miss a dose of Hylenex

Hylenex contraindications - Who shouldn't take Hylenex?

  • This medicine is not right for everyone. You should not receive it if you had an allergic reaction to hyaluronidase.

Hylenex warnings

  • Tell your doctor if you are pregnant or breastfeeding.

  • This medicine is made from donated human blood. All donated blood is tested for certain viruses. Although your risk for getting a virus from the medicine is very low, talk with your doctor if you have concerns.

Hylenex interactions & what to avoid when taking Hylenex

  • Tell your doctor if you are pregnant or breastfeeding.

  • This medicine is made from donated human blood. All donated blood is tested for certain viruses. Although your risk for getting a virus from the medicine is very low, talk with your doctor if you have concerns.

Hylenex side effects - How does Hylenex make you feel?

Serious Side Effects

  • Rapid weight gain, swelling in your hands, ankles, or feet

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

Less Serious Side Effects

  • Redness, swelling, itching, or pain at the injection site

Subscribe to our savings newsletter

Health education, drug info, wellness & more

By clicking 'Subscribe', I agree to SingleCare's Terms & Conditions.