What is Hysingla ER: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Jun 17, 2021

Hysingla ER overview

BRAND NAMES:

  • Hysingla ER, Zohydro ER

Generic Names:

  • Hydrocodone Bitartrate Er

Uses:

  • Treats severe pain. This medicine is a narcotic pain reliever.

Therapeutic Classes:

  • Analgesic

Forms:

  • Long Acting Capsule, Long Acting Tablet

How it’s taken:

  • By mouth

What is Hysingla ER used for?

What form(s) does Hysingla ER come in

  • Long Acting Capsule

  • Long Acting Tablet

What are common Hysingla ER doses?

  • Tablet Er 24 Hour Abuse-Deterrent 20MG

  • Tablet Er 24 Hour Abuse-Deterrent 30MG

  • Tablet Er 24 Hour Abuse-Deterrent 40MG

  • Tablet Er 24 Hour Abuse-Deterrent 60MG

  • Tablet Er 24 Hour Abuse-Deterrent 80MG

  • Tablet Er 24 Hour Abuse-Deterrent 100MG

  • Tablet Er 24 Hour Abuse-Deterrent 120MG

Common Hysingla ER prescriptions

  • Hysingla ER
    100mg tablet er 24 hour abuse-deterrent

  • Hysingla ER
    120mg tablet er 24 hour abuse-deterrent

  • Hysingla ER
    20mg tablet er 24 hour abuse-deterrent

  • Hysingla ER
    30mg tablet er 24 hour abuse-deterrent

  • Hysingla ER
    40mg tablet er 24 hour abuse-deterrent

  • Hysingla ER
    60mg tablet er 24 hour abuse-deterrent

  • Hysingla ER
    80mg tablet er 24 hour abuse-deterrent

How to take Hysingla ER

  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take this medicine at the same time each day.

  • An overdose can be dangerous. Follow directions carefully so you do not get too much medicine at one time. Your doctor may also give naloxone to treat an overdose.

  • Swallow the extended-release capsule whole. Do not crush, break, or chew it.

  • Swallow the extended-release tablet whole. Do not crush, break, or chew it. Do not pre-soak, lick, or wet the tablet before you place it in your mouth.

  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Store the medicine in a safe and secure place. Drop off any unused narcotic medicine at a drug take-back location right away. If you do not have a drug take-back location near you, flush any unused narcotic medicine down the toilet. Check your local drug store and clinics for take-back locations. You can also check the DEA web site for locations. Here is the link to the FDA safe disposal of medicines website: www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/ensuringsafeuseofmedicine/safedisposalofmedicines/ucm186187.htm

  • Missed dose: If you miss a dose, skip the missed dose and take your next dose as usual. Do not take extra medicine to make up for a missed dose.

What to do if you miss a dose of Hysingla ER

Hysingla ER contraindications

  • This medicine is not right for everyone. Do not use it if you had an allergic reaction to hydrocodone, or if you have serious lung or breathing problems, or stomach or bowel blockage (including paralytic ileus).

Hysingla ER warnings

  • This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, breathing or lung problems (including apnea), heart failure, heart rhythm problems (including congenital long QT syndrome, slow heartbeat), adrenal problems, digestion problems, pancreas problems, or a history of depression, head injury, seizures, or drug or alcohol abuse.

  • This medicine may cause the following problems:High risk of overdose, which can lead to deathRespiratory depression (serious breathing problem that can be life-threatening)Adrenal gland problemsLow blood pressureIncreased risk of heart rhythm problem, including QT prolongationIncreased risk of seizuresSerotonin syndrome, when used with certain medicines

  • This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully.

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Hysingla ER interactions

  • Some medicines can affect how hydrocodone works. Tell your doctor if you are using any of the following:Carbamazepine, erythromycin, ketoconazole, lactulose, mirtazapine, phenytoin, rifampin, ritonavir, tramadol, trazodoneBenzodiazepine medicineDiuretic (water pill)Medicine to treat depression or mental health problems (including SNRIs, SSRIs, TCAs)Phenothiazine medicineTriptan medicine to treat migraine headaches

  • Do not drink alcohol while you are using this medicine. Do not take any medicine that contains alcohol.

  • Tell your doctor if you use anything else that makes you sleepy. Some examples are allergy medicine, narcotic pain medicine, and alcohol. Tell your doctor if you are also using buprenorphine, butorphanol, nalbuphine, pentazocine, or a muscle relaxer (including cyclobenzaprine, metaxalone).

  • This medicine can be habit-forming. Do not use more than your prescribed dose. Call your doctor if you think your medicine is not working.

  • Do not use this medicine if you have used an MAO inhibitor within the past 14 days.

  • Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.

  • This medicine may cause constipation, especially with long-term use. Ask your doctor if you should use a laxative to prevent and treat constipation.

  • Keep all medicine out of the reach of children. Never share your medicine with anyone. An overdose in a child could cause death.

Hysingla ER side effects

Serious Side Effects

  • Extreme dizziness, drowsiness, or weakness, slow heartbeat, seizures, and cold, clammy skin

  • Trouble breathing or slow breathing

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

  • Changes in skin color, dark freckles, cold feeling, tiredness, weight loss

  • Anxiety, restlessness, fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, seeing or hearing things that are not there

  • Fast, pounding, or uneven heartbeat

  • Severe confusion, lightheadedness, dizziness, or fainting

  • Blue lips, fingernails, or skin, trouble breathing

Less Serious Side Effects

  • Sleepiness

  • Constipation, stomach pain, nausea, vomiting

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