What is Iclusig? Uses, warnings & side effects

How to take Iclusig

• Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

• Swallow the tablet whole. Do not crush, break, chew, or dissolve it.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

• Oral routeMedicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Swallow the tablet whole. Do not crush, break, chew, or dissolve it.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

What to do if you miss a dose of Iclusig

Iclusig contraindications - Who shouldn't take Iclusig?

• This medicine is not right for everyone. Do not use it if you had an allergic reaction to ponatinib, or if you are pregnant.

Iclusig warnings

• Oral routeIt is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant. Use an effective birth control during treatment and for 3 weeks after your last dose of this medicine.

• Do not breastfeed during treatment and for at least 6 days after your last dose.

• Tell your doctor if you have liver disease, blood clotting problems, diabetes, heart or blood vessel disease, heart failure, high blood pressure, or a history of a heart attack, stroke, pancreas problems, stomach problems (such as hole, fistula), or alcohol abuse. Tell your doctor if you are lactose intolerant.

• This medicine may cause the following problems:Blood clots, which could lead to heart attack or strokeHigh blood pressure, heart failure, heart rhythm problems, retaining fluidDamage or problems with the liver, pancreas, eyes, nerves, or digestive systemSevere bleedingReversible posterior leukoencephalopathy syndrome (RPLS)Tumor lysis syndromeSlow healing of wounds

• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

• If you plan to have children, talk with your doctor before using this medicine. Some women using this medicine may become infertile (unable to have children).

• Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Rapid weight gain, swelling in your hands, ankles, or feet

• Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

• Unusual bleeding, bruising, or weakness

Iclusig interactions & what to avoid when taking Iclusig

• Some medicines can affect how ponatinib works. Tell your doctor if you are using boceprevir, carbamazepine, clarithromycin, conivaptan, indinavir, itraconazole, ketoconazole, lansoprazole, lopinavir/ritonavir, nefazodone, nelfinavir, phenytoin, posaconazole, rifampin, ritonavir, saquinavir, St John's wort, telaprevir, telithromycin, or voriconazole.

• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

• This medicine may cause the following problems:Blood clots, which could lead to heart attack or strokeHigh blood pressure, heart failure, heart rhythm problems, retaining fluidDamage or problems with the liver, pancreas, eyes, nerves, or digestive systemSevere bleedingTumor lysis syndromeSlow healing of wounds

• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.

• Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.