What is Janumet XR: Uses, Warnings & Interactions

How to take Janumet XR

• Extended-release tablet: Take this medicine in the evening.You may see tablets in your stools. If this happens several times, tell your doctor right away.

• Swallow the tablet whole. Do not crush, break, or chew it.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

• Oral routeIt is best to take this medicine with food or milk.

• Drink plenty of fluids to help prevent dehydration.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

• Swallow the tablet whole. Do not crush, break, or chew it.

• Missed dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

• Extended-release tablet: Take this medicine in the evening.You may see tablets in your stools. If this happens several times, tell your doctor right away.

• Oral routeIt is best to take this medicine with food or milk.

• Drink plenty of fluids to help prevent dehydration.

What to do if you miss a dose of Janumet XR

Janumet XR contraindications

• This medicine is not right for everyone. Do not use it if you had an allergic reaction to metformin or sitagliptin.

Janumet XR warnings

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, adrenal or pituitary gland disease, high cholesterol, vitamin B12 deficiency, or a history of heart failure or pancreatitis.

• This medicine may cause the following problems:Lactic acidosis (too much acid in the blood, which can be life-threatening)Pancreatitis (inflammation of the pancreas)Heart failureKidney problemsLow levels of vitamin B12 in the bloodLow blood sugarSerious skin reactions

• Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may interact with the dye used for an x-ray or a CT scan.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.

• Shaking, trembling, sweating, fast or pounding heartbeat, faintness, hunger, confusion

• Sudden and severe stomach pain, nausea, vomiting, fever, lightheadedness

• Paleness, feeling tired or weak

Janumet XR interactions

• Some medicines can affect how metformin/sitagliptin works. Tell your doctor if you are using any of the following: Cimetidine, digoxin, dolutegravir, morphine, phenytoin, quinine, ranitidine, ranolazine, vandetanibBlood pressure medicine (including amiloride)Diuretic (water pill, including acetazolamide, dichlorphenamide, triamterene)Insulin or other diabetes medicineMedicine for heart rhythm changes (including procainamide, quinidine)Medicine to treat infections (including isoniazid, rifampin, trimethoprim, vancomycin)Medicine to treat seizures (including phenytoin, topiramate, zonisamide)

• Some medicines may affect your blood sugar level, including a diuretic (water pill), birth control pills, corticosteroid (including dexamethasone, hydrocortisone, methylprednisolone, prednisolone, prednisone), phenothiazine medicine (including chlorpromazine, perphenazine, prochlorperazine, promethazine, thioridazine), thyroid medicine, niacin, and isoniazid. Closely monitor your blood sugar levels when you start or stop another medicine while you are using sitagliptin/metformin.

• Limit the amount of alcohol you drink while you are using this medicine. Heavy alcohol use increases your risk for lactic acidosis.

• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

• Keep all medicine out of the reach of children. Never share your medicine with anyone.