Leucovorin is a prescription form of folinic acid, a pre-activated and easily metabolized form of folic acid (vitamin B9). Healthcare professionals use it primarily as a "rescue" medication in people undergoing certain cancer treatments (like high-dose methotrexate) or people with severe folic acid deficiency (megaloblastic anemia). The cash price of Leucovorin averages about $36.97 per 12, 5mg tablets. Reduce your cost to $8.51 for 12, 5mg tablets by using a Leucovorin coupon from SingleCare at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 08/03/2026
Leucovorin is a prescription form of folinic acid, a pre-activated and easily metabolized form of folic acid (vitamin B9). Healthcare professionals use it primarily as a "rescue" medication in people undergoing certain cancer treatments (like high-dose methotrexate) or people with severe folic acid deficiency (megaloblastic anemia). The cash price of Leucovorin averages about $36.97 per 12, 5mg tablets. Reduce your cost to $8.51 for 12, 5mg tablets by using a Leucovorin coupon from SingleCare at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Leucovorin Calcium Retail Price | Leucovorin Calcium SingleCare Price |
|---|---|---|
| CVS Pharmacy | $29.46 | $9.80 |
| Walgreens | $28.50 | $6.63 |
| Kroger Pharmacy | $20.38 | $10.94 |
| Albertsons Pharmacy | $39.00 | $23.16 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Leucovorin is a prescription form of folinic acid, a pre-activated and easily metabolized form of folic acid (vitamin B9). Healthcare professionals use it primarily as a "rescue" medication in people undergoing certain cancer treatments (like high-dose methotrexate) or people with severe folic acid deficiency (megaloblastic anemia). The cash price of Leucovorin averages about $36.97 per 12, 5mg tablets. Reduce your cost to $8.51 for 12, 5mg tablets by using a Leucovorin coupon from SingleCare at participating pharmacies.
The generic version of Leucovorin costs $8.51 for 12, 5mg tablets with a free Leucovorin coupon from SingleCare. You could pay less depending on your Rx details. Use the dropdown menu above to update your prescription details (i.e., brand/generic, form, dosage, quantity) to get the most accurate prices of Leucovorin with SingleCare at your local pharmacies.
Without insurance coverage, the average retail price of Leucovorin is around $36.97 for 12, 5mg tablets. SingleCare can help you save money with a Leucovorin discount coupon. Pay only $8.51 for 12, 5mg tablets for your Leucovorin prescription at participating pharmacies.
The out-of-pocket cost of Leucovorin with insurance will vary based on the insurance plan. You may need to contact your insurance provider directly to get an accurate out-of-pocket cost for your Leucovorin prescription. You can also save on Leucovorin by using SingleCare's Leucovorin coupons. Your Leucovorin price can be discounted to $8.51 for 12, 5mg tablets with a free coupon from SingleCare.
Medicare plans offer coverage for Leucovorin. The copay cost and other out-of-pocket costs will depend on the specific Medicare plan. In some cases, SingleCare may be more affordable than your Medicare plan. To compare prices, present your SingleCare prescription drug discount card at checkout before you purchase this medication.
Medicaid typically covers Leucovorin at a minimal cost, without restrictions, although there may be variations between states. If coverage or the out-of-pocket cost with Medicaid is a problem, consider using a SingleCare savings card instead of Medicaid. With a discount coupon from SingleCare, Leucovorin can cost as low as $8.51 for 12, 5mg tablets.
Wellcovorin was the brand-name version of Leucovorin, but its manufacturer discontinued the drug in early 2026. Today, Leucovorin is only available as a generic.
Leucovorin is a lower-priced generic drug, but there are still a few ways to save money.
The first step is to compare pharmacy prices for Leucovorin to find the lowest price. Search for your medication on SingleCare’s website or app and enter your zip code to find the pharmacies with the lowest Leucovorin prices near you.
Use a free Leucovorin coupon from SingleCare to lower the price of Leucovorin to $8.51 for 12, 5mg tablets. To unlock our lowest prices and earn bonus savings on other medications, sign up for SingleCare for free.
Other ways to save money on Leucovorin include applying for Medicaid or Medicare Part D Extra Help. Additionally, the prescribing healthcare provider can provide information about community services that offer Leucovorin at a discounted price, such as 340B clinics or hospitals.
There is no safe over-the-counter alternative to Leucovorin for patients undergoing chemotherapy or treating methotrexate toxicity. While standard folic acid is a highly effective, low-cost alternative for simpler conditions like nutritional folate deficiency or megaloblastic anemia, it is NOT the same thing as Leucovorin. Leucovorin (folinic acid) bypasses the enzyme dihydrofolate reductase, which is completely blocked by chemotherapy drugs like methotrexate. If a cancer patient substitutes OTC folic acid for Leucovorin, the body will not be able to process it, leading to severe, potentially fatal chemotherapy toxicity and bone marrow suppression. Never substitute OTC supplements for Leucovorin without explicit instruction from your oncologist.
You can use SingleCare coupons at most national pharmacies and grocery stores, such as Walgreens, Kroger, Walmart, CVS, Safeway, and more. Simply text, email, print, or save your free Leucovorin coupon to your mobile wallet and show your pharmacist at checkout.
Jeff Fortner, Pharm.D., focuses his practice and research on pharmaceutical compounding, patient-centered care in the community setting, and pharmacist-provided clinical services. He maintains a practice site at an independent community pharmacy that also specializes in non-sterile compounding and long-term care medication preparation. Dr. Fortner enjoys spending time with his wife and two young daughters, trying and sharing new craft beers, reading sci-fi/fantasy fiction, and cycling.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
© 2026 SingleCare Administrators. All rights reserved
© 2026 SingleCare Administrators. All rights reserved