What is Methylphenidate ER (OSM)? Uses, warnings & side effects

Follow the prescriber’s instructions.

Please read the Medication Guide that comes with the medicine.

Take only one tablet daily.

Take each day’s dose in the morning.

Swallow the tablet whole with water or other liquid. Do not crush, break, or chew it.

Store methylphenidate ER osmotic-release tablets in a closed container at room temperature. Protect from humidity.

Ask the prescriber how to manage a missed dose.

As a general rule, a missed dose can be taken anytime in the morning.

• Taking it later in the day may cause sleep problems in the evening.

This medicine is not right for everyone. 

Do not use it if you have had an allergic reaction to methylphenidate.

Tell any doctor or other healthcare professional who treats you that you or your child is taking methylphenidate.

• This drug may need to be stopped before surgery.

Methylphenidate tablets do not have refills. Monthly prescriptions require monthly visits with a healthcare provider to assess treatment and monitor the patient’s health. Keep all appointments.

Tell the prescriber if you are pregnant, breastfeeding, or if you have:

• A history of heart problems 

• A history of heart disease

• A heart defect

• High blood pressure

• Circulation problems in the feet or legs

• Eye problems, including glaucoma, high eye pressure, or farsightedness

• Intestinal blockage or narrowing

• A history of seizures

• A history of abnormal brain wave tests (EEGs)

• A personal or family history of psychiatric problems, including depression, bipolar disorder, or psychosis

• Tourette syndrome, motor tics, or a family history of Tourette syndrome

• Bouts of anxiety or agitation

• A history of drug abuse or addiction

Methylphenidate can cause serious problems, including:

• Serious heart or blood vessel problems, including heart attack or stroke

• Circulation problems in the hands and feet

• High blood pressure

• Increased pressure in the eye

• Glaucoma

• Prolonged and painful erections

• Growth suppression in children

This medicine can worsen underlying psychiatric issues like anxiety, mania, psychosis, or motor tics.

This medicine can cause dizziness or blurry vision. Avoid driving or other potentially hazardous activities until you understand this medicine’s effects.

Methylphenidate can be habit-forming. Do not use more than prescribed. Talk to the prescriber if the treatment does not seem to be working.

Methylphenidate is a federally controlled substance. Selling or giving this medicine to another person is hazardous and illegal.

Do not use methylphenidate if you are using or have used an MAO inhibitor (MAOI) within the past 14 days.

Tell the prescriber about all the prescription drugs, over-the-counter medications, and supplements being regularly taken, particularly:

• Other stimulants

• Blood pressure medications

• Drugs that narrow blood vessels (vasopressors)

• Blood thinners called coumarin anticoagulants (like warfarin)

• Drugs that treat depression

• The antipsychotic drug risperidone

Avoid drinking alcohol when taking extended-release methylphenidate. 

Tell other healthcare providers about methylphenidate before they prescribe new medications or schedule medical procedures that require inhaled anesthetics.