What is Ninjacof: Uses, Warnings & Interactions

Updated May 14, 2025  •  Published Dec 30, 2020

Ninjacof is an over-the-counter combination cold medicine used to relieve symptoms of the common cold, hay fever, and upper respiratory tract allergies. Ninjacof combines two drugs: chlophedianol, a cough suppressant, and pyrilamine, an antihistamine. Ninjacof is safe enough to use without a prescription but has several warnings and drug interactions that consumers should be aware of before taking this medicine.

Ninjacof overview

BRAND NAMES:

  • Ninjacof

Generic Names:

  • Chlophedianol/pyrilamine maleate

Uses:

  • Treats cough, runny nose, sneezing, watery eyes, and itchy nose due to colds, hay fever, or upper respiratory allergies

Therapeutic Classes:

  • Antihistamine/antitussive combination

Forms:

  • Oral solution (liquid)

How it’s taken:

  • By mouth

What is Ninjacof used for?

Ninjacof combines a cough suppressant and an antihistamine to relieve symptoms of the common cold and upper respiratory tract allergies, such as cough, runny nose, itchy and watery eyes, and sneezing.

What form(s) does Ninjacof come in

  • Oral solution

    • 12.5 mg chlophedianol / 12.5 mg pyrilamine

What are common Ninjacof doses?

  • For relief of cold or upper respiratory tract allergies:

    • In adults and children 12 years of age and older: 2 teaspoons (10 mL) every 6–8 hours to a maximum of 8 teaspoons every 24 hours

    • In children 6–12 years old: 1 teaspoon (5 mL) every 6–8 hours to a maximum of 4 teaspoons every 24 hours

Common Ninjacof prescriptions

  • Ninjacof
    473ml of 12.5-12.5mg/5ml bottle

How to take Ninjacof

  • Follow the instructions on the medicine label if you are using this medicine without a prescription. Take doses exactly as instructed.

  • If this medicine is prescribed by a doctor, follow the doctor’s instructions.

  • The bottle does not need to be shaken before measuring a dose.

  • Use a calibrated measuring device to measure each dose. Don’t guess at the measurement or use tableware.

  • Store Ninjacof at room temperature.

What to do if you miss a dose of Ninjacof

  • Doses should be taken six to eight hours apart.

  • If a dose is missed, take it when remembered. Do not take another dose until six to eight hours later.

  • Do not take a double dose to make up for a missed dose.

Ninjacof contraindications

  • Although Ninjacof can be purchased and used without a prescription, some people should not take it.

  • Ninjacof is not safe to take if you are also taking a prescription drug called a monoamine oxidase inhibitor (MAOI). 

Ninjacof warnings

  • Tell any doctor or other healthcare provider who treats you that you are using this medicine.

  • Before using Ninjacof, talk to a doctor if you have:

    • Chronic cough

    • Cough with excessive phlegm

    • Serious breathing problems such as COPD

    • Glaucoma

    • Urination problems due to enlarged prostate

  • Women who are pregnant or breastfeeding should talk to a doctor before using Ninjacof.

  • Do not give Ninjacof to a child younger than six years old except under the advice of a doctor.

  • This medicine may make you very drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.

  • Ninjacof can cause excitability in children.

  • Stop taking Ninjacof and call a doctor if:

    • Symptoms do not improve after 7 days

    • New symptoms appear, such as headache, fever, or rash

    • Side effects such as nervousness, dizziness, or insomnia are experienced

  • Ninjacof is sweetened with sucralose and comes in a cotton candy flavor to appeal to children. Keep it securely out of reach of children to prevent overdose. 

  • In case of an overdose, get immediate medical help or call a poison helpline.

Ninjacof interactions

  • To avoid possible drug interactions, tell healthcare providers you are taking Ninjacof before they prescribe any new medications.

  • Ninjacof can cause serious side effects if combined with MAO inhibitors. MAOIs must be stopped for at least 14 days before Ninjacof is safe to take. If you’re unsure about what you’re taking, find a list of MAO inhibitors here.

  • Ninjacof can make you drowsy. Some people may get excessively drowsy when taking Ninjacof. Do not use any other medicines that make you sleepy, such as sleeping pills, narcotic pain relievers, and sedatives.

  • Avoid drinking alcohol when using Ninjacof.

Ninjacof side effects

Less serious side effects

  • Drowsiness 

  • Excitability (in children)

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