Nucynta ER is a prescription medication used to relieve severe pain that does not respond to other treatment options. It is also approved for severe nerve pain caused by diabetes, also known as diabetic peripheral neuropathy. Nucynta ER is the brand name for tapentadol, which works as an opioid pain medication to alter the way your brain responds to pain signals. The average retail price of Nucynta ER is $1,602.96 for 60, 100mg tablets. You could pay $1,194.57 for 60, 100mg tablets instead of full price by using a SingleCare Nucynta ER coupon at a participating pharmacy.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/20/2025
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Nucynta ER is a prescription medication used to relieve severe pain that does not respond to other treatment options. It is also approved for severe nerve pain caused by diabetes, also known as diabetic peripheral neuropathy. Nucynta ER is the brand name for tapentadol, which works as an opioid pain medication to alter the way your brain responds to pain signals. The average retail price of Nucynta ER is $1,602.96 for 60, 100mg tablets. You could pay $1,194.57 for 60, 100mg tablets instead of full price by using a SingleCare Nucynta ER coupon at a participating pharmacy.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Nucynta ER is a prescription medication used to relieve severe pain that does not respond to other treatment options. It is also approved for severe nerve pain caused by diabetes, also known as diabetic peripheral neuropathy. Nucynta ER is the brand name for tapentadol, which works as an opioid pain medication to alter the way your brain responds to pain signals. The average retail price of Nucynta ER is $1,602.96 for 60, 100mg tablets. You could pay $1,194.57 for 60, 100mg tablets instead of full price by using a SingleCare Nucynta ER coupon at a participating pharmacy.
If you do not have health insurance coverage, then your Nucynta ER costs may be as high as $1,602.96 for 60, 100mg tablets. Prescription prices can fluctuate, however, depending on the pharmacy and location. With a SingleCare discount coupon, you could save significantly, reducing the price to $1,194.57 for 60, 100mg tablets at participating pharmacies.
The average cost of Nucynta ER with insurance may vary depending on the type of insurance plan you are enrolled in and the benefits you are entitled to. Insurance coverage can vary greatly, affecting the price you pay for your prescription. In addition, you may still be responsible for a copay or out-of-pocket expense. Always consult your insurance company for the most recent information if you have questions about your insurance coverage.
Coverage via Medicare Part D and Medicare Advantage plans can vary. Check your specific plan for coverage information. Even if you have a Medicare drug benefit plan, you could access greater savings using a SingleCare savings card or coupon. Pay only $1,194.57 for Nucynta ER when you present your SingleCare copay card at participating local pharmacies. You could reduce your cost to $1,194.57 for 60, 100mg tablets with SingleCare.
Nucynta ER is a brand-name prescription drug. There is currently no generic alternative available for this medication. A generic alternative may not be available until the patent for the brand name expires in 2025.
Nucynta ER is an FDA-approved prescription opioid medication used to relieve severe chronic pain that doesn’t respond to other pain medications or treatments. It is also approved to treat nerve pain caused by diabetic peripheral neuropathy (DPN) in patients with diabetes. In some cases, it may be used for severe acute pain under close observation.
The active ingredient in this drug is tapentadol. It works by acting on opioid receptors in the brain, thus altering the way the brain perceives pain. It has a prolonged period of action, making it suitable for chronic pain conditions.
Nucynta ER comes as an extended-release oral tablet. It can be taken with or without food and should only be used as directed by your doctor or healthcare provider. A low dose may be recommended by your doctor at the beginning of treatment. This may then be gradually increased over time until your pain is controlled.
While Nucynta ER may be effective in treating pain, it may also cause some unwanted side effects, such as:
Drowsiness
Nausea
Dizziness
Constipation
Contact your doctor or pharmacist if these side effects develop, persist, or worsen.
Serious side effects may include allergic reactions, life-threatening or fatal respiratory depression, and serotonin syndrome. The risk of serious side effects may be increased if Nucynta ER is taken with other prescription drugs, including benzodiazepines, other opioids, and selective serotonin reuptake inhibitors (SSRIs). Seek immediate medical attention if you experience signs of an allergic reaction, such as hives, rash, or trouble breathing.
Tell your healthcare provider if you are pregnant or breastfeeding, as this medication may harm an unborn baby or breastfeeding child. You should also tell your doctor or healthcare provider about other medical conditions you may have, including liver disease, kidney disease, breathing problems, major depression, or other types of mental illness.
This is not a complete list of side effects. Consult a healthcare provider for medical advice and more information about potential side effects, interactions, and precautions.
Nucynta ER is a Schedule II controlled substance, which means it can be highly addictive. Misusing Nucynta ER can lead to opioid addiction or opioid use disorder, overdose, or even death. Your doctor may have to assess your condition to see if the benefits of this medication outweigh the risks. Seek immediate medical help if you experience signs of an overdose, such as trouble breathing, extreme drowsiness, slowed heartbeat, or unresponsiveness.
Abruptly stopping the use of an opioid may lead to withdrawal symptoms. Symptoms of withdrawal may include anxiety, irritability, sweating, shivering, and nausea. Your doctor may reduce your dose gradually over time in order to reduce the risk of withdrawal.
The half-life of Nucynta ER is around five hours on average. This is how long it takes for half of the drug to be eliminated from the body. The half-life should not be confused with shelf life, which is how long the drug will last in optimal conditions before it starts to break down. The shelf life of Nucynta ER is around 24 to 36 months when stored at room temperature away from moisture and heat.
Gerardo Sison, Pharm.D., graduated from the University of Florida. He has worked in both community and hospital settings, providing drug information and medication therapy management services. As a medical writer, he hopes to educate and empower patients to better manage their health and navigate their treatment plans.
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SingleCare is a prescription discount service that offers free coupons on thousands of prescription drugs. It can be used whether you have insurance, Medicare, Medicaid, or none of the above, but it cannot be combined with insurance.
SingleCare provides transparent drug pricing, so you can compare discounts at pharmacies near you. Browse singlecare.com to find drug discounts, helpful information about your prescription, and resources to help you make informed health decisions.
Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
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© 2025 SingleCare Administrators. All rights reserved