What is Prempro: Uses, Warnings & Interactions

Your doctor will tell you how much medicine to use. Do not use more than directed.

Please read the Patient Information sheet that comes with the medicine.

Take only one tablet daily. 

Take the tablet at the same time every day.

Do not remove tablets from the blister pack until you’re about to take the tablet.

Swallow the tablet with a drink of water.

Store the tablets in their blister pack and original carton at room temperature.

Take a missed dose as soon as it’s remembered.

Skip the missed dose if it’s almost time for the next dose.

Do not take two tablets to make up for a missed dose.

This medicine is not right for everyone. 

Do not use it if you have had an allergic reaction to estrogen or progestin, are pregnant, or have:

• Abnormal vaginal bleeding that has not been checked by a doctor

• Certain types of hormone-dependent cancers, such as breast or ovary cancer

• A history of stroke

• A history of heart attack

• A history of liver disease

• A bleeding disorder

Tell any doctor or other healthcare provider who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or need certain types of medical tests.

The doctor will need to regularly review the treatment with you, adjust the dose, and perform blood tests. Keep all appointments. 

Tell the doctor about all your medical conditions, particularly:

• Unusual vaginal bleeding

• Asthma

• Epilepsy (seizures)

• Diabetes

• Migraine

• Heart problems

• Liver problems

• Kidney problems

• Thyroid problems

• Parathyroid problems

• High calcium

• High blood pressure

• High cholesterol or a family history of high cholesterol

• Lupus 

• Porphyria

• Endometriosis

Estrogen therapy can cause serious problems, including:

• Heart attack

• Stroke

• Blood clots

• Breast cancer

• Uterine cancer

• Ovarian cancer

• Enlargement of benign tumors of the uterus (fibroids)

• Liver problems

• Gallbladder problems

• High blood pressure

• High triglyceride levels 

• Fluid retention

• Depression

• Severe allergic reactions

Immediately inform the prescriber if you have unusual vaginal bleeding.

Prempro can cause blood clots in the eye. Immediately call the prescriber if you have a sudden loss of vision, vision changes, or a bad headache. An eye doctor may need to check your eyes.

To avoid possible drug interactions, tell the prescribing healthcare provider about all the prescription drugs, over-the-counter medications, and supplements being taken, particularly:

• Macrolide antibiotics such as clarithromycin or erythromycin

• Oral azole antifungals such as ketoconazole or itraconazole

• Antiviral drugs called protease inhibitors

• Carbamazepine, Paxlovid, phenobarbital, St. John’s wort

Do not drink grapefruit juice when being treated with Prempro.

Tell other healthcare providers you are using this medicine before they prescribe new medications.