Prilosec OTC is an over-the-counter (OTC) medication used as a treatment for certain esophagus and stomach problems including acid reflux and ulcers. This medication works by reducing the amount of acid that your stomach produces. Omeprazole OTC is the generic version of Prilosec OTC. The average cost of Prilosec OTC is around $25.24 per 1, 28 tablets delayed release box. You can save on this total and pay only $14.38 per 1, 28 tablets delayed release box by using a SingleCare Prilosec OTC coupon at participating pharmacies.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
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Prices updated: 12/05/2025
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Prilosec OTC is an over-the-counter (OTC) medication used as a treatment for certain esophagus and stomach problems including acid reflux and ulcers. This medication works by reducing the amount of acid that your stomach produces. Omeprazole OTC is the generic version of Prilosec OTC. The average cost of Prilosec OTC is around $25.24 per 1, 28 tablets delayed release box. You can save on this total and pay only $14.38 per 1, 28 tablets delayed release box by using a SingleCare Prilosec OTC coupon at participating pharmacies.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Prilosec Otc Retail Price | Omeprazole Magnesium Retail Price | Omeprazole Magnesium SingleCare Price |
|---|---|---|---|
| Walmart | - | $21.00 | $21.00 |
| Walgreens | $24.08 | $23.88 | $13.78 |
| Kroger Pharmacy | - | $26.75 | $16.78 |
| Albertsons Pharmacy | - | $22.40 | $20.44 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Prilosec OTC is an over-the-counter (OTC) medication used as a treatment for certain esophagus and stomach problems including acid reflux and ulcers. This medication works by reducing the amount of acid that your stomach produces. Omeprazole OTC is the generic version of Prilosec OTC. The average cost of Prilosec OTC is around $25.24 per 1, 28 tablets delayed release box. You can save on this total and pay only $14.38 per 1, 28 tablets delayed release box by using a SingleCare Prilosec OTC coupon at participating pharmacies.
If you do not have health insurance coverage then your Prilosec OTC costs may be as high as $25.24. Save on this total by using a SingleCare Prilosec OTC discount card. Pay just $14.38 for your Prilosec OTC refill when you use SingleCare's discount card or Prilosec OTC coupons at neighborhood pharmacies such as Harris Teeter, Walgreens, and Duane Reade.
Health insurance coverage usually is not available for over-the-counter (OTC) drugs like Prilosec OTC. Your doctor may write a prescription for Prilosec OTC, but otherwise, pharmacy coupons are usually the cheapest option in getting Prilosec OTC. Pay just $14.38 when you use one of our SingleCare coupons for Prilosec OTC.
Medicare coverage is currently not available for Prilosec OTC. You may still be able to save money on this medication by using a SingleCare Prilosec OTC coupon. Redeem instant savings and pay only $14.38 for your Prilosec OTC purchase at participating pharmacies.
Prilosec OTC is a brand-name over-the-counter medication and the generic alternative is omeprazole OTC.
Prilosec OTC is an FDA-approved over the counter medication used as a treatment for certain esophagus and stomach problems including acid reflux and ulcers. This medication works by reducing the amount of acid that your stomach produces. This medication helps to relieve symptoms such as difficulty swallowing, persistent cough, and heartburn. It may also help to heal the damage done to the stomach and esophagus from excess acid and may even be effective in preventing esophageal cancer. Prilosec OTC is a part of a group of drugs referred to as proton pump inhibitors.
This product does not work immediately to relieve heartburn. It may take as much as one to four days before you start experiencing the full effect of this medication. This medication comes in the form of an oral tablet and should be taken as directed by your doctor. The dose and period of treatment are usually based on your doctor's assessment of your health and your body's response to treatment.
Common side effects resulting from the use of Prilosec OTC may include abdominal pain or headaches. These effects may be experienced when you first take this medication and usually go away after your body becomes accustomed to it. If you experience these side effects and they persist or worsen, you should inform your doctor immediately.
Seek medical attention immediately if you notice any serious side effects such as irregular heartbeats, muscle spasms, seizures, or signs of lupus. In rare cases, this medication may cause a vitamin B-12 deficiency. The risk of this occurring increases if you have been using this medication for an extended period. Contact your doctor right away if you experience symptoms of a vitamin B-12 deficiency such as unusual weakness, sore tongue, or numbness in the hands or feet.
This is not a complete list of side effects. Other side effects not mentioned here may also occur while you're taking this medication. Consult with your doctor for medical advice on any side effects you may be experiencing while using Prilosec OTC.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved