Prolia is a prescription medication used as a treatment for bone loss in women who are at an especially high risk for bone fracture after menopause. It may also be used by men who are also experiencing bone loss. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of fractures. For every 1, 1ml of 60mg/ml syringe, the average retail price of Prolia is around $2,259.01. You can save on this medication and pay $1,834.13 by using a SingleCare Prolia coupon at participating pharmacies such as CVS Pharmacy, Target, Longs Drugs, Walmart Pharmacy, Kroger, and Fry's.
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SingleCare’s prescription prices are based on multiple sources. The prices we publish are our best estimate, but we cannot guarantee that the price we display will exactly match the price you receive at the pharmacy. For an exact price, please contact your pharmacy and provide the BIN/GRP/PCN numbers shown on your SingleCare card.
Any SingleCare bonus savings, including the $3 signup bonus, may only be used once.
Prices updated: 12/05/2025
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Prolia is a prescription medication used as a treatment for bone loss in women who are at an especially high risk for bone fracture after menopause. It may also be used by men who are also experiencing bone loss. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of fractures. For every 1, 1ml of 60mg/ml syringe, the average retail price of Prolia is around $2,259.01. You can save on this medication and pay $1,834.13 by using a SingleCare Prolia coupon at participating pharmacies such as CVS Pharmacy, Target, Longs Drugs, Walmart Pharmacy, Kroger, and Fry's.
Our price history metrics are calculated from aggregate prescription data that we receive from all participating pharmacies. This chart updates daily to show new price fluctuations. If a data point is missing from the chart, it is because we do not have enough data to produce a reliable figure.
| Pharmacy | Prolia Retail Price | Prolia SingleCare Price |
|---|---|---|
| Walmart | $2250.52 | $2250.52 |
| Walgreens | $2299.59 | $1988.58 |
| Kroger Pharmacy | $2250.49 | $1839.17 |
These prices are based on the last month of SingleCare prescription fill data by major pharmacy. This table updates daily to show the most accurate typical prices by pharmacies. If a data point is missing from the table, it is because we do not have enough data to produce a reliable figure.
Prolia is a prescription medication used as a treatment for bone loss in women who are at an especially high risk for bone fracture after menopause. It may also be used by men who are also experiencing bone loss. This medication works by slowing bone loss to help maintain strong bones and reduce the risk of fractures. For every 1, 1ml of 60mg/ml syringe, the average retail price of Prolia is around $2,259.01. You can save on this medication and pay $1,834.13 by using a SingleCare Prolia coupon at participating pharmacies such as CVS Pharmacy, Target, Longs Drugs, Walmart Pharmacy, Kroger, and Fry's.
If you do not have health insurance coverage, then your out-of-pocket costs for Prolia may be as high as $2,259.01 for 1, 1ml of 60mg/ml syringe. Save on this total by using a SingleCare Prolia coupon. Pay our lowest price of $1,834.13 for your Prolia refill when you use our free coupons at neighborhood pharmacies such as Harris Teeter, Walgreens, and Duane Reade.
Prolia prices with insurance may vary based on the type of insurance plan you have. Contact your insurance provider directly to find out exactly how much Prolia costs under your insurance plan.
SingleCare can help you to easily save on your Prolia purchases. Pay $1,834.13 for 1, 1ml of 60mg/ml syringe of Prolia purchase when you use SingleCare's Prolia coupons.
Prolia is currently covered under Medicare Part D and Medicare Advantage Plans. Under Medicare your copay range for Prolia could be between $70 and $1,364. Pricing varies by plan and prescription.
Using a SingleCare discount card can also help you to save money on your Prolia cost. Present your discount card at local pharmacies today and pay only $1,834.13 for 1, 1ml of 60mg/ml syringe of Prolia.
Prolia is a brand-name prescription drug. There is no generic alternative available for this medication.
Prolia is an FDA-approved prescription medication used to treat osteoporosis in women who are at high risk for bone fracture due to menopause. Osteoporosis is a form of bone disease that arises when your body loses an excess amount of bone tissue or makes too little bone. Due to this, bones become weak and may break easily. The risk of developing osteoporosis usually increases after menopause.
Denosumab is the active ingredient in Prolia and it works by blocking a protein in the body known as RANK ligand. By blocking this protein, Prolia limits the activity of cells that break down old bone material. This helps to increase bone mass and strength.
This medication comes in the form of an injection that is administered in the upper arm, upper thigh, or abdomen. You should only use this medication in doses that are approved by your doctor. Prolia is usually taken once every six months. This medication may also be taken with calcium and vitamin D in order to boost its effectiveness in encouraging bone growth.
This medication may cause calcium levels to decline, especially if you are suffering from kidney problems. Your doctor may recommend that you take calcium and vitamin D to counteract this side effect. Calcium blood tests may also be needed before your first injection and during treatment to monitor your progress. Contact your doctor right away if you experience signs of low calcium such as muscle spasms, numbness, mood changes, irregular heartbeats, and severe dizziness.
Prolia may also negatively affect your immune system. You may be more likely to get a serious infection such as ear, skin or bladder infection while using this medication. Tell your doctor right away if you notice signs of any infections such as fever, muscle pain, back pain, chills, swollen skin, or severe abdominal pain.
This is not a complete list of side effects so you can also experience other effects not listed here while using this medication. Consult your healthcare provider for medical advice on the risks and benefits involved with using Prolia.
Kristi C. Torres, Pharm.D., is a 2005 graduate of The University of Texas at Austin. Her professional background includes academic teaching roles, district-level management for a nationwide pharmacy chain, and clinic-based pharmacy management. Dr. Torres has a wide range of experience in pharmacy operations and has traveled to many states to open and convert clinic-based pharmacies for one of the largest healthcare systems in the nation.
Currently, she works for Tarrytown Expocare Pharmacy in Austin, Texas, serving the intellectual and developmental disability community. There, she leads the order entry team, overseeing orders from across the country.
Dr. Torres began working in pharmacy at the age of 16 in a small East Texas town. She currently resides in Round Rock, Texas, with her daughter and a Shih-Tzu puppy.
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Prescription savings vary by prescription and by pharmacy, and may reach up to 80% off cash price. This is a medical discount plan. This is NOT insurance. This program offers you the opportunity to locate providers of various types of medical services who will offer their services to you at discounted rates. The range of discounts for medical or ancillary services provided under the plan will vary depending on the type of provider and service received. You are fully responsible for paying for all health care services but will be entitled to receive a discount from those health care providers in accordance with the specific pre-negotiated discounted fee schedule. This program does not guarantee the quality of the services or procedures offered by the providers. Except for prescription drugs which you will pay directly to the pharmacy at the time of purchase, all other services received through a program provider will be charged to the credit card on file in your member account. The charge will include an administrative fee for use of the program. Towers Administrators LLC is the licensed discount medical plan organization with its administrative office located at 4510 Cox Road, Suite 111, Glen Allen, VA 23060. SingleCare Services, LLC is the marketer of the discount medical plan organization including its website, singlecare.com, with its corporate office located at 99 High Street, Suite 2800, Boston, MA 02110. For additional information, including an up-to-date list of providers, or assistance with any issue related to program membership, please contact member support any time at www.singlecare.com, or by calling toll-free 844-234-3057, 24 hours, 7 days a week (except major holidays). Pharmacy names, logos, brands, and other trademarks are the property of their respective owners.
Blog articles are not medical advice. They are intended for general informational purposes and are not meant to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911.
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© 2025 SingleCare Administrators. All rights reserved